YTA12 (YMR089C)


Gene profile

Gene name: YTA12
Reference locus (S288C): YMR089C
Gene biotype: protein_coding

Description: Mitochondrial respiratory chain complexes assembly protein YTA12; Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins; also required for correct assembly of mitochondrial enzyme complexes; overexpression of human AFG3L2 complements respiratory defect of yeast afg3 yta12 double null mutation, but overexpression of disease-associated AFG3L2 variants does not; expression of both human SPG7 (paraplegin) and AFG3L2 complements yeast yta12 afg3 double mutation; In the N-terminal section; belongs to the AAA ATPase family

Top 10 interactors (score): AFG3 (0.992); PHB1 (0.971); MBA1 (0.97); PHB2 (0.967); PIM1 (0.929); OMA1 (0.88); PCP1 (0.875); OXA1 (0.863); CCP1 (0.805); SSC1 (0.801); ATP23 (0.787); HSP60 (0.768); PUF3 (0.763); MGR3 (0.759); TIM10 (0.747); MGR1 (0.727); ATP12 (0.708); MCX1 (0.706); IFM1 (0.7); MGM1 (0.692)

Homologues (species, bitscore): AFG3L2 (Homo sapiens, 676.4); Afg3l2 (Mus musculus, 679.5); afg3l2 (Danio rerio, 682.9); afg3l1p (Xenopus tropicalis, 663.7); CG6512 (Drosophila melanogaster, 663.3); spg-7 (Caenorhabditis elegans, 628.6); ftsh3 (Arabidopsis thaliana, 651.7)

External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser


Comparative analysis of strains

Search table

strain assembly application macro_region gene_coord geneID rnaID protID %id %cov_exon status copyNumber copyID nORFs match_ref_CDS validORF missing_startCodon missing_stopCodon outOfFrame_stopCodon
AKU4011 GCA_001738255.1 Sake Asia CM005307.1:483546-486023:- gene-YMR089C_AKU4011 rna-NM_001182589.1_AKU4011 cds-NP_013807.1_AKU4011 99.8 100.0 Verified 1 1 1 False True False False False
BG1 GCA_001932575.1 Bioethanol South America MSHP01000201.1:56988-59468:+ gene-YMR089C_BG1 rna-NM_001182589.1_BG1 cds-NP_013807.1_BG1 98.9 100.0 Verified 1 1 1 False True False False False
Bruggeman GCA_001738585.1 Bread Not Applicable CM005515.1:425725-428202:- gene-YMR089C_Bruggeman rna-NM_001182589.1_Bruggeman cds-NP_013807.1_Bruggeman 99.8 100.0 Verified 1 1 1 False True False False False
CAT1 GCA_001738705.1 Bioethanol South America CM005531.1:426050-428527:- gene-YMR089C_CAT1 rna-NM_001182589.1_CAT1 cds-NP_013807.1_CAT1 99.7 100.0 Verified 1 1 1 False True False False False
CBS1585 GCA_001738375.1 Sake Asia CM005371.1:416486-418966:- gene-YMR089C_CBS1585 rna-NM_001182589.1_CBS1585 cds-NP_013807.1_CBS1585 99.7 100.0 Unannotated 1 1 0 False False False False True
CBS436 GCA_001738355.1 Sake Asia CM005355.1:421809-424286:- gene-YMR089C_CBS436 rna-NM_001182589.1_CBS436 cds-NP_013807.1_CBS436 99.1 100.0 Mismatch 1 1 1 False True False False False
CBS6412 GCA_001738345.1 Sake Asia CM005339.1:529585-532062:- gene-YMR089C_CBS6412 rna-NM_001182589.1_CBS6412 cds-NP_013807.1_CBS6412 99.9 100.0 Mismatch 1 1 1 True True False False False
CBS6413 GCA_001738265.1 Sake Asia CM005323.1:415743-418223:- gene-YMR089C_CBS6413 rna-NM_001182589.1_CBS6413 cds-NP_013807.1_CBS6413 99.7 100.0 Verified 1 1 1 False True False False False
CENPK1137D GCA_000269885.1 Laboratory Not Applicable CM001534.1:439712-442189:- gene-YMR089C_CENPK1137D rna-NM_001182589.1_CENPK1137D cds-NP_013807.1_CENPK1137D 99.1 100.0 Verified 1 1 1 False True False False False
EthanolRed GCA_001738615.1 Bioethanol Asia CM005483.1:416377-418857:- gene-YMR089C_EthanolRed rna-NM_001182589.1_EthanolRed cds-NP_013807.1_EthanolRed 99.7 100.0 Verified 1 1 1 False True False False False
FaliES1 GCA_001738715.1 Bioethanol Asia CM005547.1:419543-422023:- gene-YMR089C_FaliES1 rna-NM_001182589.1_FaliES1 cds-NP_013807.1_FaliES1 99.7 100.0 Verified 1 1 1 False True False False False
JAY291 GCA_000182315.2 Bioethanol South America ACFL01000033.1:15192-17669:+ gene-YMR089C_JAY291 rna-NM_001182589.1_JAY291 cds-NP_013807.1_JAY291 99.1 100.0 Verified 1 1 1 False True False False False
MUCL30387 GCA_001738515.1 Bread Europe CM005419.1:421985-424462:- gene-YMR089C_MUCL30387 rna-NM_001182589.1_MUCL30387 cds-NP_013807.1_MUCL30387 99.3 100.0 Verified 1 1 1 False True False False False
MUCL30388 GCA_001738495.1 Bread Europe CM005451.1:426888-429365:- gene-YMR089C_MUCL30388 rna-NM_001182589.1_MUCL30388 cds-NP_013807.1_MUCL30388 99.7 100.0 Verified 1 1 1 False True False False False
MUCL39482 GCA_001738235.1 Sake Asia CM005291.1:416798-419275:- gene-YMR089C_MUCL39482 rna-NM_001182589.1_MUCL39482 cds-NP_013807.1_MUCL39482 99.8 100.0 Unannotated 1 1 0 False False False False True
MUCL42920 GCA_001738485.1 Bread Europe CM005435.1:423463-425940:- gene-YMR089C_MUCL42920 rna-NM_001182589.1_MUCL42920 cds-NP_013807.1_MUCL42920 99.8 100.0 Verified 1 1 1 False True False False False
NCIM3186 GCA_001029075.1 Bioethanol Asia CP011822.1:445563-448040:- gene-YMR089C_NCIM3186 rna-NM_001182589.1_NCIM3186 cds-NP_013807.1_NCIM3186 98.9 100.0 Verified 1 1 1 False True False False False
NCYC1407 GCA_001738225.1 Sake Asia CM005275.1:416690-419170:- gene-YMR089C_NCYC1407 rna-NM_001182589.1_NCYC1407 cds-NP_013807.1_NCYC1407 99.7 100.0 Verified 1 1 1 False True False False False
PE2H3 GCA_905220325.1 Bioethanol South America HG994152.1:422410-424887:- gene-YMR089C_PE2H3 rna-NM_001182589.1_PE2H3 cds-NP_013807.1_PE2H3 99.1 100.0 Verified 1 1 1 False True False False False
PE2H4 GCA_905220315.1 Bioethanol South America LR999884.1:428505-430982:- gene-YMR089C_PE2H4 rna-NM_001182589.1_PE2H4 cds-NP_013807.1_PE2H4 99.1 100.0 Verified 1 1 1 False True False False False
S288C GCF_000146045.2 Laboratory Not applicable NC_001145.3:445609-448086:- gene-YMR089C_S288C rna-NM_001182589.1_S288C cds-NP_013807.1_S288C 100.0 100.0 Verified 1 1 1 True True False False False
SA1 GCA_004114265.1 Bioethanol South America SDIA01000005.1:102082-104559:+ gene-YMR089C_SA1 rna-NM_001182589.1_SA1 cds-NP_013807.1_SA1 99.1 100.0 Verified 1 1 1 False True False False False
ThermosaccDry GCA_001738605.1 Bioethanol Asia CM005499.1:417346-419826:- gene-YMR089C_ThermosaccDry rna-NM_001182589.1_ThermosaccDry cds-NP_013807.1_ThermosaccDry 99.7 100.0 Verified 1 1 1 False True False False False
VR1 GCA_001738595.1 Bioethanol South America CM005467.1:428996-431473:- gene-YMR089C_VR1 rna-NM_001182589.1_VR1 cds-NP_013807.1_VR1 99.4 100.0 Verified 1 1 1 False True False False False
ZTW1 GCA_000308935.1 Bioethanol Asia AMDD01000027.1:393616-396096:- gene-YMR089C_ZTW1 rna-NM_001182589.1_ZTW1 cds-NP_013807.1_ZTW1 99.7 100.0 Verified 1 1 1 False True False False False
Sparadoxus GCF_002079055.1 Not applicable Not applicable NC_047499.1:430082-432559:- gene-YMR089C_Sparadoxus rna-NM_001182589.1_Sparadoxus cds-NP_013807.1_Sparadoxus 90.5 100.0 Verified 1 1 1 False True False False False

Additional files