Gene name: YTA12
Reference locus (S288C): YMR089C
Gene biotype: protein_coding
Description: Mitochondrial respiratory chain complexes assembly protein YTA12; Mitochondrial inner membrane m-AAA protease component; mediates degradation of misfolded or unassembled proteins; also required for correct assembly of mitochondrial enzyme complexes; overexpression of human AFG3L2 complements respiratory defect of yeast afg3 yta12 double null mutation, but overexpression of disease-associated AFG3L2 variants does not; expression of both human SPG7 (paraplegin) and AFG3L2 complements yeast yta12 afg3 double mutation; In the N-terminal section; belongs to the AAA ATPase family
Top 10 interactors (score): AFG3 (0.992); PHB1 (0.971); MBA1 (0.97); PHB2 (0.967); PIM1 (0.929); OMA1 (0.88); PCP1 (0.875); OXA1 (0.863); CCP1 (0.805); SSC1 (0.801); ATP23 (0.787); HSP60 (0.768); PUF3 (0.763); MGR3 (0.759); TIM10 (0.747); MGR1 (0.727); ATP12 (0.708); MCX1 (0.706); IFM1 (0.7); MGM1 (0.692)
Homologues (species, bitscore): AFG3L2 (Homo sapiens, 676.4); Afg3l2 (Mus musculus, 679.5); afg3l2 (Danio rerio, 682.9); afg3l1p (Xenopus tropicalis, 663.7); CG6512 (Drosophila melanogaster, 663.3); spg-7 (Caenorhabditis elegans, 628.6); ftsh3 (Arabidopsis thaliana, 651.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:483546-486023:- | gene-YMR089C_AKU4011 | rna-NM_001182589.1_AKU4011 | cds-NP_013807.1_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000201.1:56988-59468:+ | gene-YMR089C_BG1 | rna-NM_001182589.1_BG1 | cds-NP_013807.1_BG1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005515.1:425725-428202:- | gene-YMR089C_Bruggeman | rna-NM_001182589.1_Bruggeman | cds-NP_013807.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005531.1:426050-428527:- | gene-YMR089C_CAT1 | rna-NM_001182589.1_CAT1 | cds-NP_013807.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005371.1:416486-418966:- | gene-YMR089C_CBS1585 | rna-NM_001182589.1_CBS1585 | cds-NP_013807.1_CBS1585 | 99.7 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005355.1:421809-424286:- | gene-YMR089C_CBS436 | rna-NM_001182589.1_CBS436 | cds-NP_013807.1_CBS436 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:529585-532062:- | gene-YMR089C_CBS6412 | rna-NM_001182589.1_CBS6412 | cds-NP_013807.1_CBS6412 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005323.1:415743-418223:- | gene-YMR089C_CBS6413 | rna-NM_001182589.1_CBS6413 | cds-NP_013807.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001534.1:439712-442189:- | gene-YMR089C_CENPK1137D | rna-NM_001182589.1_CENPK1137D | cds-NP_013807.1_CENPK1137D | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005483.1:416377-418857:- | gene-YMR089C_EthanolRed | rna-NM_001182589.1_EthanolRed | cds-NP_013807.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005547.1:419543-422023:- | gene-YMR089C_FaliES1 | rna-NM_001182589.1_FaliES1 | cds-NP_013807.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000033.1:15192-17669:+ | gene-YMR089C_JAY291 | rna-NM_001182589.1_JAY291 | cds-NP_013807.1_JAY291 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005419.1:421985-424462:- | gene-YMR089C_MUCL30387 | rna-NM_001182589.1_MUCL30387 | cds-NP_013807.1_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005451.1:426888-429365:- | gene-YMR089C_MUCL30388 | rna-NM_001182589.1_MUCL30388 | cds-NP_013807.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005291.1:416798-419275:- | gene-YMR089C_MUCL39482 | rna-NM_001182589.1_MUCL39482 | cds-NP_013807.1_MUCL39482 | 99.8 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005435.1:423463-425940:- | gene-YMR089C_MUCL42920 | rna-NM_001182589.1_MUCL42920 | cds-NP_013807.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011822.1:445563-448040:- | gene-YMR089C_NCIM3186 | rna-NM_001182589.1_NCIM3186 | cds-NP_013807.1_NCIM3186 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005275.1:416690-419170:- | gene-YMR089C_NCYC1407 | rna-NM_001182589.1_NCYC1407 | cds-NP_013807.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994152.1:422410-424887:- | gene-YMR089C_PE2H3 | rna-NM_001182589.1_PE2H3 | cds-NP_013807.1_PE2H3 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999884.1:428505-430982:- | gene-YMR089C_PE2H4 | rna-NM_001182589.1_PE2H4 | cds-NP_013807.1_PE2H4 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001145.3:445609-448086:- | gene-YMR089C_S288C | rna-NM_001182589.1_S288C | cds-NP_013807.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000005.1:102082-104559:+ | gene-YMR089C_SA1 | rna-NM_001182589.1_SA1 | cds-NP_013807.1_SA1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005499.1:417346-419826:- | gene-YMR089C_ThermosaccDry | rna-NM_001182589.1_ThermosaccDry | cds-NP_013807.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:428996-431473:- | gene-YMR089C_VR1 | rna-NM_001182589.1_VR1 | cds-NP_013807.1_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000027.1:393616-396096:- | gene-YMR089C_ZTW1 | rna-NM_001182589.1_ZTW1 | cds-NP_013807.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:430082-432559:- | gene-YMR089C_Sparadoxus | rna-NM_001182589.1_Sparadoxus | cds-NP_013807.1_Sparadoxus | 90.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |