YPT52 (YKR014C)


Gene profile

Gene name: YPT52
Reference locus (S288C): YKR014C
Gene biotype: protein_coding

Description: GTP-binding protein YPT52; Endosomal Rab family GTPase; required for vacuolar protein sorting, endocytosis and multivesicular body (MVB) biogenesis and sorting; required for localization of the CORVET complex to endosomes; involved in autophagy and ionic stress tolerance; similar to Vps21p and Ypt53p; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress

Top 10 interactors (score): VPS8 (0.999); VPS9 (0.999); VPS16 (0.999); GDI1 (0.996); MUK1 (0.988); PEP7 (0.987); VAM6 (0.984); VPS21 (0.982); VPS3 (0.979); PEP3 (0.978); MRS6 (0.977); ROY1 (0.974); PEP5 (0.974); VPS33 (0.967); VPS34 (0.964); VPS41 (0.951); VPS45 (0.907); YPT53 (0.87); MSB3 (0.867); SKP1 (0.853)

Homologues (species, bitscore): RAB5C (Homo sapiens, 193.7); Rab5a (Mus musculus, 190.7); rab5aa (Danio rerio, 190.7); rab5c (Xenopus tropicalis, 190.7); Rab5 (Drosophila melanogaster, 201.1); rab-5 (Caenorhabditis elegans, 188.0); ARA7 (Arabidopsis thaliana, 181.0)

External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser


Comparative analysis of strains

Search table

strain assembly application macro_region gene_coord geneID rnaID protID %id %cov_exon status copyNumber copyID nORFs match_ref_CDS validORF missing_startCodon missing_stopCodon outOfFrame_stopCodon
AKU4011 GCA_001738255.1 Sake Asia CM005305.1:451033-451737:- gene-YKR014C_AKU4011 rna-NM_001179804.1_AKU4011 cds-NP_012939.1_AKU4011 99.7 100.0 Verified 1 1 1 True True False False False
BG1 GCA_001932575.1 Bioethanol South America MSHP01000113.1:191763-192467:+ gene-YKR014C_BG1 rna-NM_001179804.1_BG1 cds-NP_012939.1_BG1 99.8 100.0 Verified 1 1 1 True True False False False
Bruggeman GCA_001738585.1 Bread Not Applicable CM005513.1:472709-473413:- gene-YKR014C_Bruggeman rna-NM_001179804.1_Bruggeman cds-NP_012939.1_Bruggeman 100.0 100.0 Verified 1 1 1 True True False False False
CAT1 GCA_001738705.1 Bioethanol South America CM005529.1:468448-469152:- gene-YKR014C_CAT1 rna-NM_001179804.1_CAT1 cds-NP_012939.1_CAT1 99.8 100.0 Verified 1 1 1 True True False False False
CBS1585 GCA_001738375.1 Sake Asia CM005369.1:463773-464477:- gene-YKR014C_CBS1585 rna-NM_001179804.1_CBS1585 cds-NP_012939.1_CBS1585 99.7 100.0 Verified 1 1 1 True True False False False
CBS436 GCA_001738355.1 Sake Asia CM005353.1:462607-463311:- gene-YKR014C_CBS436 rna-NM_001179804.1_CBS436 cds-NP_012939.1_CBS436 100.0 100.0 Mismatch 1 1 1 True True False False False
CBS6412 GCA_001738345.1 Sake Asia CM005337.1:447934-448638:- gene-YKR014C_CBS6412 rna-NM_001179804.1_CBS6412 cds-NP_012939.1_CBS6412 99.7 100.0 Mismatch 1 1 1 True True False False False
CBS6413 GCA_001738265.1 Sake Asia CM005321.1:463601-464305:- gene-YKR014C_CBS6413 rna-NM_001179804.1_CBS6413 cds-NP_012939.1_CBS6413 99.7 100.0 Verified 1 1 1 True True False False False
CENPK1137D GCA_000269885.1 Laboratory Not Applicable CM001532.1:465072-465776:- gene-YKR014C_CENPK1137D rna-NM_001179804.1_CENPK1137D cds-NP_012939.1_CENPK1137D 100.0 100.0 Verified 1 1 1 True True False False False
EthanolRed GCA_001738615.1 Bioethanol Asia CM005481.1:461503-462207:- gene-YKR014C_EthanolRed rna-NM_001179804.1_EthanolRed cds-NP_012939.1_EthanolRed 99.5 100.0 Verified 1 1 1 True True False False False
FaliES1 GCA_001738715.1 Bioethanol Asia CM005545.1:464432-465136:- gene-YKR014C_FaliES1 rna-NM_001179804.1_FaliES1 cds-NP_012939.1_FaliES1 99.5 100.0 Verified 1 1 1 True True False False False
JAY291 GCA_000182315.2 Bioethanol South America ACFL01000077.1:88622-89326:+ gene-YKR014C_JAY291 rna-NM_001179804.1_JAY291 cds-NP_012939.1_JAY291 99.8 100.0 Verified 1 1 1 True True False False False
MUCL30387 GCA_001738515.1 Bread Europe CM005417.1:472023-472727:- gene-YKR014C_MUCL30387 rna-NM_001179804.1_MUCL30387 cds-NP_012939.1_MUCL30387 99.8 100.0 Verified 1 1 1 True True False False False
MUCL30388 GCA_001738495.1 Bread Europe CM005449.1:467713-468417:- gene-YKR014C_MUCL30388 rna-NM_001179804.1_MUCL30388 cds-NP_012939.1_MUCL30388 100.0 100.0 Verified 1 1 1 True True False False False
MUCL39482 GCA_001738235.1 Sake Asia CM005289.1:463090-463794:- gene-YKR014C_MUCL39482 rna-NM_001179804.1_MUCL39482 cds-NP_012939.1_MUCL39482 99.7 100.0 Verified 1 1 1 True True False False False
MUCL42920 GCA_001738485.1 Bread Europe CM005433.1:468866-469570:- gene-YKR014C_MUCL42920 rna-NM_001179804.1_MUCL42920 cds-NP_012939.1_MUCL42920 100.0 100.0 Verified 1 1 1 True True False False False
NCIM3186 GCA_001029075.1 Bioethanol Asia CP011820.1:465356-466060:- gene-YKR014C_NCIM3186 rna-NM_001179804.1_NCIM3186 cds-NP_012939.1_NCIM3186 99.4 100.0 Verified 1 1 1 False True False False False
NCYC1407 GCA_001738225.1 Sake Asia CM005273.1:463297-464001:- gene-YKR014C_NCYC1407 rna-NM_001179804.1_NCYC1407 cds-NP_012939.1_NCYC1407 99.7 100.0 Verified 1 1 1 True True False False False
PE2H3 GCA_905220325.1 Bioethanol South America HG994150.1:488284-488988:- gene-YKR014C_PE2H3 rna-NM_001179804.1_PE2H3 cds-NP_012939.1_PE2H3 99.7 100.0 Verified 1 1 1 False True False False False
PE2H4 GCA_905220315.1 Bioethanol South America LR999882.1:473007-473711:- gene-YKR014C_PE2H4 rna-NM_001179804.1_PE2H4 cds-NP_012939.1_PE2H4 99.8 100.0 Verified 1 1 1 True True False False False
S288C GCF_000146045.2 Laboratory Not applicable NC_001143.9:465367-466071:- gene-YKR014C_S288C rna-NM_001179804.1_S288C cds-NP_012939.1_S288C 100.0 100.0 Verified 1 1 1 True True False False False
SA1 GCA_004114265.1 Bioethanol South America SDIA01000078.1:47677-48381:+ gene-YKR014C_SA1 rna-NM_001179804.1_SA1 cds-NP_012939.1_SA1 100.0 100.0 Verified 1 1 1 True True False False False
ThermosaccDry GCA_001738605.1 Bioethanol Asia CM005497.1:463688-464392:- gene-YKR014C_ThermosaccDry rna-NM_001179804.1_ThermosaccDry cds-NP_012939.1_ThermosaccDry 99.5 100.0 Verified 1 1 1 True True False False False
VR1 GCA_001738595.1 Bioethanol South America CM005465.1:463304-464008:- gene-YKR014C_VR1 rna-NM_001179804.1_VR1 cds-NP_012939.1_VR1 99.8 100.0 Verified 1 1 1 True True False False False
ZTW1 GCA_000308935.1 Bioethanol Asia AMDD01000022.1:461734-462438:- gene-YKR014C_ZTW1 rna-NM_001179804.1_ZTW1 cds-NP_012939.1_ZTW1 99.7 100.0 Verified 1 1 1 True True False False False
Sparadoxus GCF_002079055.1 Not applicable Not applicable NC_047497.1:487200-487904:- gene-YKR014C_Sparadoxus rna-NM_001179804.1_Sparadoxus cds-NP_012939.1_Sparadoxus 93.4 100.0 Verified 1 1 1 False True False False False

Additional files