Gene name: YPT52
Reference locus (S288C): YKR014C
Gene biotype: protein_coding
Description: GTP-binding protein YPT52; Endosomal Rab family GTPase; required for vacuolar protein sorting, endocytosis and multivesicular body (MVB) biogenesis and sorting; required for localization of the CORVET complex to endosomes; involved in autophagy and ionic stress tolerance; similar to Vps21p and Ypt53p; mammalian Rab5 homolog; protein abundance increases in response to DNA replication stress
Top 10 interactors (score): VPS8 (0.999); VPS9 (0.999); VPS16 (0.999); GDI1 (0.996); MUK1 (0.988); PEP7 (0.987); VAM6 (0.984); VPS21 (0.982); VPS3 (0.979); PEP3 (0.978); MRS6 (0.977); ROY1 (0.974); PEP5 (0.974); VPS33 (0.967); VPS34 (0.964); VPS41 (0.951); VPS45 (0.907); YPT53 (0.87); MSB3 (0.867); SKP1 (0.853)
Homologues (species, bitscore): RAB5C (Homo sapiens, 193.7); Rab5a (Mus musculus, 190.7); rab5aa (Danio rerio, 190.7); rab5c (Xenopus tropicalis, 190.7); Rab5 (Drosophila melanogaster, 201.1); rab-5 (Caenorhabditis elegans, 188.0); ARA7 (Arabidopsis thaliana, 181.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:451033-451737:- | gene-YKR014C_AKU4011 | rna-NM_001179804.1_AKU4011 | cds-NP_012939.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000113.1:191763-192467:+ | gene-YKR014C_BG1 | rna-NM_001179804.1_BG1 | cds-NP_012939.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:472709-473413:- | gene-YKR014C_Bruggeman | rna-NM_001179804.1_Bruggeman | cds-NP_012939.1_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:468448-469152:- | gene-YKR014C_CAT1 | rna-NM_001179804.1_CAT1 | cds-NP_012939.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:463773-464477:- | gene-YKR014C_CBS1585 | rna-NM_001179804.1_CBS1585 | cds-NP_012939.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:462607-463311:- | gene-YKR014C_CBS436 | rna-NM_001179804.1_CBS436 | cds-NP_012939.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:447934-448638:- | gene-YKR014C_CBS6412 | rna-NM_001179804.1_CBS6412 | cds-NP_012939.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:463601-464305:- | gene-YKR014C_CBS6413 | rna-NM_001179804.1_CBS6413 | cds-NP_012939.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:465072-465776:- | gene-YKR014C_CENPK1137D | rna-NM_001179804.1_CENPK1137D | cds-NP_012939.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:461503-462207:- | gene-YKR014C_EthanolRed | rna-NM_001179804.1_EthanolRed | cds-NP_012939.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:464432-465136:- | gene-YKR014C_FaliES1 | rna-NM_001179804.1_FaliES1 | cds-NP_012939.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000077.1:88622-89326:+ | gene-YKR014C_JAY291 | rna-NM_001179804.1_JAY291 | cds-NP_012939.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:472023-472727:- | gene-YKR014C_MUCL30387 | rna-NM_001179804.1_MUCL30387 | cds-NP_012939.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:467713-468417:- | gene-YKR014C_MUCL30388 | rna-NM_001179804.1_MUCL30388 | cds-NP_012939.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:463090-463794:- | gene-YKR014C_MUCL39482 | rna-NM_001179804.1_MUCL39482 | cds-NP_012939.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:468866-469570:- | gene-YKR014C_MUCL42920 | rna-NM_001179804.1_MUCL42920 | cds-NP_012939.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:465356-466060:- | gene-YKR014C_NCIM3186 | rna-NM_001179804.1_NCIM3186 | cds-NP_012939.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:463297-464001:- | gene-YKR014C_NCYC1407 | rna-NM_001179804.1_NCYC1407 | cds-NP_012939.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:488284-488988:- | gene-YKR014C_PE2H3 | rna-NM_001179804.1_PE2H3 | cds-NP_012939.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:473007-473711:- | gene-YKR014C_PE2H4 | rna-NM_001179804.1_PE2H4 | cds-NP_012939.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:465367-466071:- | gene-YKR014C_S288C | rna-NM_001179804.1_S288C | cds-NP_012939.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000078.1:47677-48381:+ | gene-YKR014C_SA1 | rna-NM_001179804.1_SA1 | cds-NP_012939.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:463688-464392:- | gene-YKR014C_ThermosaccDry | rna-NM_001179804.1_ThermosaccDry | cds-NP_012939.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:463304-464008:- | gene-YKR014C_VR1 | rna-NM_001179804.1_VR1 | cds-NP_012939.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:461734-462438:- | gene-YKR014C_ZTW1 | rna-NM_001179804.1_ZTW1 | cds-NP_012939.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:487200-487904:- | gene-YKR014C_Sparadoxus | rna-NM_001179804.1_Sparadoxus | cds-NP_012939.1_Sparadoxus | 93.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |