Gene name: YPS1
Reference locus (S288C): YLR120C
Gene biotype: protein_coding
Description: Aspartic proteinase 3; Aspartic protease; hyperglycosylated member of the yapsin family of proteases, attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor; involved in nutrient limitation-induced cleavage of the extracellular inhibitory domain of signaling mucin Msb2p, resulting in activation of the filamentous growth MAPK pathway; involved with other yapsins in the cell wall integrity response; role in KEX2-independent processing of the alpha factor precursor
Top 10 interactors (score): KEX2 (0.986); MKC7 (0.955); MSB2 (0.937); PRB1 (0.877); PRC1 (0.753); DDI1 (0.705); RCN2 (0.691); KEX1 (0.688); YPS3 (0.672); RRT12 (0.655); NCW2 (0.65); SMP3 (0.611); IRC22 (0.597); YPS7 (0.56); YIL082W-A (0.52); CRZ1 (0.52); STE24 (0.499); GAS1 (0.493); YSP3 (0.492); YGR109W-B (0.481)
Homologues (species, bitscore): PGC (Homo sapiens, 119.0); Pgc (Mus musculus, 98.6); NAPSA (Danio rerio, 84.7); pga4 (Xenopus tropicalis, 106.7); CG31928 (Drosophila melanogaster, 85.1); asp-16 (Caenorhabditis elegans, 81.3); AT4G04460 (Arabidopsis thaliana, 71.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:368994-370703:- | gene-YLR120C_AKU4011 | rna-NM_001182007.1_AKU4011 | cds-NP_013221.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000212.1:332770-334479:- | gene-YLR120C_BG1 | rna-NM_001182007.1_BG1 | cds-NP_013221.1_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:380118-381827:- | gene-YLR120C_Bruggeman | rna-NM_001182007.1_Bruggeman | cds-NP_013221.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:380035-381744:- | gene-YLR120C_CAT1 | rna-NM_001182007.1_CAT1 | cds-NP_013221.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:376137-377846:- | gene-YLR120C_CBS1585 | rna-NM_001182007.1_CBS1585 | cds-NP_013221.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:366375-368084:- | gene-YLR120C_CBS436 | rna-NM_001182007.1_CBS436 | cds-NP_013221.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:374555-376264:- | gene-YLR120C_CBS6412 | rna-NM_001182007.1_CBS6412 | cds-NP_013221.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:376403-378112:- | gene-YLR120C_CBS6413 | rna-NM_001182007.1_CBS6413 | cds-NP_013221.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:371533-373242:- | gene-YLR120C_CENPK1137D | rna-NM_001182007.1_CENPK1137D | cds-NP_013221.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:369195-370904:- | gene-YLR120C_EthanolRed | rna-NM_001182007.1_EthanolRed | cds-NP_013221.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:368706-370415:- | gene-YLR120C_FaliES1 | rna-NM_001182007.1_FaliES1 | cds-NP_013221.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000117.1:22783-24492:+ | gene-YLR120C_JAY291 | rna-NM_001182007.1_JAY291 | cds-NP_013221.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:376410-378119:- | gene-YLR120C_MUCL30387 | rna-NM_001182007.1_MUCL30387 | cds-NP_013221.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:385191-386900:- | gene-YLR120C_MUCL30388 | rna-NM_001182007.1_MUCL30388 | cds-NP_013221.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:376646-378355:- | gene-YLR120C_MUCL39482 | rna-NM_001182007.1_MUCL39482 | cds-NP_013221.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:376772-378481:- | gene-YLR120C_MUCL42920 | rna-NM_001182007.1_MUCL42920 | cds-NP_013221.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:386485-388194:- | gene-YLR120C_NCIM3186 | rna-NM_001182007.1_NCIM3186 | cds-NP_013221.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:368919-370628:- | gene-YLR120C_NCYC1407 | rna-NM_001182007.1_NCYC1407 | cds-NP_013221.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:374480-376189:- | gene-YLR120C_PE2H3 | rna-NM_001182007.1_PE2H3 | cds-NP_013221.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:374221-375930:- | gene-YLR120C_PE2H4 | rna-NM_001182007.1_PE2H4 | cds-NP_013221.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:386511-388220:- | gene-YLR120C_S288C | rna-NM_001182007.1_S288C | cds-NP_013221.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000055.1:12386-14095:- | gene-YLR120C_SA1 | rna-NM_001182007.1_SA1 | cds-NP_013221.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:369916-371625:- | gene-YLR120C_ThermosaccDry | rna-NM_001182007.1_ThermosaccDry | cds-NP_013221.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:382375-384084:- | gene-YLR120C_VR1 | rna-NM_001182007.1_VR1 | cds-NP_013221.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000023.1:367714-369423:- | gene-YLR120C_ZTW1 | rna-NM_001182007.1_ZTW1 | cds-NP_013221.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:377548-379257:- | gene-YLR120C_Sparadoxus | rna-NM_001182007.1_Sparadoxus | cds-NP_013221.1_Sparadoxus | 90.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |