Gene name: YPR1
Reference locus (S288C): YDR368W
Gene biotype: protein_coding
Description: Putative reductase 1; NADPH-dependent aldo-keto reductase; reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases; protein abundance increases in response to DNA replication stress; YPR1 has a paralog, GCY1, that arose from the whole genome duplication; human homolog AKR1B1 can complement yeast null mutant
Top 10 interactors (score): DAK1 (0.864); SOR1 (0.857); SOR2 (0.855); DAK2 (0.837); YMR226C (0.809); GCY1 (0.763); XKS1 (0.754); XYL2 (0.693); GRE2 (0.676); GRE3 (0.645); GPP2 (0.643); YGL039W (0.597); QRI1 (0.576); ATF2 (0.566); GSH2 (0.559); RBK1 (0.524); HIS4 (0.516); GLO1 (0.515); NTF2 (0.513); GUT2 (0.493)
Homologues (species, bitscore): AKR1B1 (Homo sapiens, 217.6); Akr1a1 (Mus musculus, 222.2); akr1b1.2 (Danio rerio, 240.7); akr1a1 (Xenopus tropicalis, 226.9); CG12766 (Drosophila melanogaster, 201.1); Y39G8B.1 (Caenorhabditis elegans, 194.1); ChlAKR (Arabidopsis thaliana, 209.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:1154047-1154985:+ | gene-YDR368W_AKU4011 | rna-NM_001180676.1_AKU4011 | cds-NP_010656.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000039.1:32596-33534:+ | gene-YDR368W_BG1 | rna-NM_001180676.1_BG1 | cds-NP_010656.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:1184697-1185635:+ | gene-YDR368W_Bruggeman | rna-NM_001180676.1_Bruggeman | cds-NP_010656.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:1163290-1164228:+ | gene-YDR368W_CAT1 | rna-NM_001180676.1_CAT1 | cds-NP_010656.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:1148764-1149702:+ | gene-YDR368W_CBS1585 | rna-NM_001180676.1_CBS1585 | cds-NP_010656.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:1167347-1168285:+ | gene-YDR368W_CBS436 | rna-NM_001180676.1_CBS436 | cds-NP_010656.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:1145024-1145962:+ | gene-YDR368W_CBS6412 | rna-NM_001180676.1_CBS6412 | cds-NP_010656.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:1166914-1167852:+ | gene-YDR368W_CBS6413 | rna-NM_001180676.1_CBS6413 | cds-NP_010656.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:1212556-1213494:+ | gene-YDR368W_CENPK1137D | rna-NM_001180676.1_CENPK1137D | cds-NP_010656.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:1158450-1159388:+ | gene-YDR368W_EthanolRed | rna-NM_001180676.1_EthanolRed | cds-NP_010656.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:1161733-1162671:+ | gene-YDR368W_FaliES1 | rna-NM_001180676.1_FaliES1 | cds-NP_010656.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000057.1:28400-29338:- | gene-YDR368W_JAY291 | rna-NM_001180676.1_JAY291 | cds-NP_010656.1_JAY291 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:1167997-1168935:+ | gene-YDR368W_MUCL30387 | rna-NM_001180676.1_MUCL30387 | cds-NP_010656.1_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:1150603-1151541:+ | gene-YDR368W_MUCL30388 | rna-NM_001180676.1_MUCL30388 | cds-NP_010656.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:1140298-1141236:+ | gene-YDR368W_MUCL39482 | rna-NM_001180676.1_MUCL39482 | cds-NP_010656.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:1082729-1083667:+ | gene-YDR368W_MUCL42920 | rna-NM_001180676.1_MUCL42920 | cds-NP_010656.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:1213827-1214765:+ | gene-YDR368W_NCIM3186 | rna-NM_001180676.1_NCIM3186 | cds-NP_010656.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:1153969-1154907:+ | gene-YDR368W_NCYC1407 | rna-NM_001180676.1_NCYC1407 | cds-NP_010656.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:1164402-1165340:+ | gene-YDR368W_PE2H3 | rna-NM_001180676.1_PE2H3 | cds-NP_010656.1_PE2H3 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:1169987-1170925:+ | gene-YDR368W_PE2H4 | rna-NM_001180676.1_PE2H4 | cds-NP_010656.1_PE2H4 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:1213904-1214842:+ | gene-YDR368W_S288C | rna-NM_001180676.1_S288C | cds-NP_010656.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000072.1:32677-33615:+ | gene-YDR368W_SA1 | rna-NM_001180676.1_SA1 | cds-NP_010656.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:1166014-1166952:+ | gene-YDR368W_ThermosaccDry | rna-NM_001180676.1_ThermosaccDry | cds-NP_010656.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:593366-594304:+ | gene-YDR368W_VR1 | rna-NM_001180676.1_VR1 | cds-NP_010656.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000008.1:208846-209784:+ | gene-YDR368W_ZTW1 | rna-NM_001180676.1_ZTW1 | cds-NP_010656.1_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:1160494-1161432:+ | gene-YDR368W_Sparadoxus | rna-NM_001180676.1_Sparadoxus | cds-NP_010656.1_Sparadoxus | 89.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |