Gene name: YPK1
Reference locus (S288C): YKL126W
Gene biotype: protein_coding
Description: Serine/threonine-protein kinase YPK1; S/T protein kinase; phosphorylates, downregulates flippase activator Fpk1p; inactivates Orm1p and Orm2p by phosphorylation in response to compromised sphingolipid synthesis; involved in the TORC-dependent phosphorylation of ribosomal proteins Rps6a/b (S6); mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; human homolog SGK1 can complement a null mutant; human homolog SGK2 can complement a ypk1 ypk2 double mutant
Top 10 interactors (score): AVO1 (0.999); TOR2 (0.997); TSC11 (0.996); LST8 (0.984); BIT2 (0.963); BCK1 (0.947); TOR1 (0.943); BIT61 (0.935); ORM1 (0.923); KOG1 (0.92); PKH1 (0.918); YPK3 (0.91); NTO1 (0.905); UBP12 (0.904); MCM1 (0.901); PHO23 (0.9); YNG1 (0.9); PKH3 (0.9); EAF6 (0.9); ESA1 (0.9)
Homologues (species, bitscore): SGK2 (Homo sapiens, 340.5); Sgk2 (Mus musculus, 334.0); sgk1 (Danio rerio, 332.0); sgk1 (Xenopus tropicalis, 331.3); Akt1 (Drosophila melanogaster, 313.9); sgk-1 (Caenorhabditis elegans, 335.9); S6K2 (Arabidopsis thaliana, 308.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:192282-194324:+ | gene-YKL126W_AKU4011 | rna-NM_001179692.1_AKU4011 | cds-NP_012796.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000030.1:169401-171443:+ | gene-YKL126W_BG1 | rna-NM_001179692.1_BG1 | cds-NP_012796.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:210193-212235:+ | gene-YKL126W_Bruggeman | rna-NM_001179692.1_Bruggeman | cds-NP_012796.1_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:205247-207289:+ | gene-YKL126W_CAT1 | rna-NM_001179692.1_CAT1 | cds-NP_012796.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:204515-206557:+ | gene-YKL126W_CBS1585 | rna-NM_001179692.1_CBS1585 | cds-NP_012796.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:203099-205141:+ | gene-YKL126W_CBS436 | rna-NM_001179692.1_CBS436 | cds-NP_012796.1_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:189142-191184:+ | gene-YKL126W_CBS6412 | rna-NM_001179692.1_CBS6412 | cds-NP_012796.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:204978-207020:+ | gene-YKL126W_CBS6413 | rna-NM_001179692.1_CBS6413 | cds-NP_012796.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:205348-207390:+ | gene-YKL126W_CENPK1137D | rna-NM_001179692.1_CENPK1137D | cds-NP_012796.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:203013-205055:+ | gene-YKL126W_EthanolRed | rna-NM_001179692.1_EthanolRed | cds-NP_012796.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:203826-205868:+ | gene-YKL126W_FaliES1 | rna-NM_001179692.1_FaliES1 | cds-NP_012796.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000357.1:26120-28162:+ | gene-YKL126W_JAY291 | rna-NM_001179692.1_JAY291 | cds-NP_012796.1_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:212019-214061:+ | gene-YKL126W_MUCL30387 | rna-NM_001179692.1_MUCL30387 | cds-NP_012796.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:206385-208427:+ | gene-YKL126W_MUCL30388 | rna-NM_001179692.1_MUCL30388 | cds-NP_012796.1_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:204308-206350:+ | gene-YKL126W_MUCL39482 | rna-NM_001179692.1_MUCL39482 | cds-NP_012796.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:208680-210722:+ | gene-YKL126W_MUCL42920 | rna-NM_001179692.1_MUCL42920 | cds-NP_012796.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:205696-207738:+ | gene-YKL126W_NCIM3186 | rna-NM_001179692.1_NCIM3186 | cds-NP_012796.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:204489-206531:+ | gene-YKL126W_NCYC1407 | rna-NM_001179692.1_NCYC1407 | cds-NP_012796.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:211587-213629:+ | gene-YKL126W_PE2H3 | rna-NM_001179692.1_PE2H3 | cds-NP_012796.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:207875-209917:+ | gene-YKL126W_PE2H4 | rna-NM_001179692.1_PE2H4 | cds-NP_012796.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:205707-207749:+ | gene-YKL126W_S288C | rna-NM_001179692.1_S288C | cds-NP_012796.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000008.1:121827-123869:+ | gene-YKL126W_SA1 | rna-NM_001179692.1_SA1 | cds-NP_012796.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:204526-206568:+ | gene-YKL126W_ThermosaccDry | rna-NM_001179692.1_ThermosaccDry | cds-NP_012796.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:203838-205880:+ | gene-YKL126W_VR1 | rna-NM_001179692.1_VR1 | cds-NP_012796.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:203059-205101:+ | gene-YKL126W_ZTW1 | rna-NM_001179692.1_ZTW1 | cds-NP_012796.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:220591-222633:+ | gene-YKL126W_Sparadoxus | rna-NM_001179692.1_Sparadoxus | cds-NP_012796.1_Sparadoxus | 93.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |