Gene name: YPF1
Reference locus (S288C): YKL100C
Gene biotype: protein_coding
Description: Intramembrane aspartyl protease of the perinuclear ER membrane; acts in a branch of ER-associated degradation (ERAD) that degrades functional proteins rather than misfolded proteins; regulates abundance of high-affinity plasma membrane transporters, such as Ctr1p and Zrt1p, during the starvation response; has a presenilin fold; member of the GxGD family of intramembrane proteases; closest human homolog is signal peptide peptidase (SPP)
Top 10 interactors (score): STT3 (0.976); ERV25 (0.971); WBP1 (0.969); COP1 (0.963); DFM1 (0.946); OST3 (0.94); SBH2 (0.922); SEC61 (0.914); SEC11 (0.907); SBH1 (0.881); SEC27 (0.871); YKE4 (0.827); DER1 (0.737); ZRT1 (0.727); SSH1 (0.705); SPC1 (0.694); SSM4 (0.686); GOS1 (0.683); SEC62 (0.633); SEC63 (0.616)
Homologues (species, bitscore): HM13 (Homo sapiens, 111.7); H13 (Mus musculus, 112.5); hm13 (Danio rerio, 113.6); sppl3 (Xenopus tropicalis, 100.9); Spp (Drosophila melanogaster, 125.6); imp-2 (Caenorhabditis elegans, 131.3); At2g03120 (Arabidopsis thaliana, 114.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:240250-242013:- | gene-YKL100C_AKU4011 | rna-NM_001179666.1_AKU4011 | cds-NP_012822.1_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000030.1:217373-219136:- | gene-YKL100C_BG1 | rna-NM_001179666.1_BG1 | cds-NP_012822.1_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:258427-260190:- | gene-YKL100C_Bruggeman | rna-NM_001179666.1_Bruggeman | cds-NP_012822.1_Bruggeman | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:253220-254983:- | gene-YKL100C_CAT1 | rna-NM_001179666.1_CAT1 | cds-NP_012822.1_CAT1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:252492-254255:- | gene-YKL100C_CBS1585 | rna-NM_001179666.1_CBS1585 | cds-NP_012822.1_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:251085-252848:- | gene-YKL100C_CBS436 | rna-NM_001179666.1_CBS436 | cds-NP_012822.1_CBS436 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:237121-238884:- | gene-YKL100C_CBS6412 | rna-NM_001179666.1_CBS6412 | cds-NP_012822.1_CBS6412 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:252948-254711:- | gene-YKL100C_CBS6413 | rna-NM_001179666.1_CBS6413 | cds-NP_012822.1_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:253338-255101:- | gene-YKL100C_CENPK1137D | rna-NM_001179666.1_CENPK1137D | cds-NP_012822.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:250943-252706:- | gene-YKL100C_EthanolRed | rna-NM_001179666.1_EthanolRed | cds-NP_012822.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:251756-253519:- | gene-YKL100C_FaliES1 | rna-NM_001179666.1_FaliES1 | cds-NP_012822.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000357.1:74084-75847:- | gene-YKL100C_JAY291 | rna-NM_001179666.1_JAY291 | cds-NP_012822.1_JAY291 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:260220-261983:- | gene-YKL100C_MUCL30387 | rna-NM_001179666.1_MUCL30387 | cds-NP_012822.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:254619-256382:- | gene-YKL100C_MUCL30388 | rna-NM_001179666.1_MUCL30388 | cds-NP_012822.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:252277-254040:- | gene-YKL100C_MUCL39482 | rna-NM_001179666.1_MUCL39482 | cds-NP_012822.1_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:256914-258677:- | gene-YKL100C_MUCL42920 | rna-NM_001179666.1_MUCL42920 | cds-NP_012822.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:253686-255449:- | gene-YKL100C_NCIM3186 | rna-NM_001179666.1_NCIM3186 | cds-NP_012822.1_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:252471-254234:- | gene-YKL100C_NCYC1407 | rna-NM_001179666.1_NCYC1407 | cds-NP_012822.1_NCYC1407 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:259559-261322:- | gene-YKL100C_PE2H3 | rna-NM_001179666.1_PE2H3 | cds-NP_012822.1_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:255845-257608:- | gene-YKL100C_PE2H4 | rna-NM_001179666.1_PE2H4 | cds-NP_012822.1_PE2H4 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:253697-255460:- | gene-YKL100C_S288C | rna-NM_001179666.1_S288C | cds-NP_012822.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000008.1:169808-171571:- | gene-YKL100C_SA1 | rna-NM_001179666.1_SA1 | cds-NP_012822.1_SA1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:252461-254224:- | gene-YKL100C_ThermosaccDry | rna-NM_001179666.1_ThermosaccDry | cds-NP_012822.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:251819-253582:- | gene-YKL100C_VR1 | rna-NM_001179666.1_VR1 | cds-NP_012822.1_VR1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:251025-252788:- | gene-YKL100C_ZTW1 | rna-NM_001179666.1_ZTW1 | cds-NP_012822.1_ZTW1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:267994-269772:- | gene-YKL100C_Sparadoxus | rna-NM_001179666.1_Sparadoxus | cds-NP_012822.1_Sparadoxus | 88.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |