Gene name: YEN1
Reference locus (S288C): YER041W
Gene biotype: protein_coding
Description: Holliday junction resolvase; promotes template switching during break-induced replication (BIR), causing non-reciprocal translocations (NRTs); localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1; similar to S. cerevisiae endonuclease Rth1p
Top 10 interactors (score): MUS81 (0.999); MMS4 (0.986); SGS1 (0.98); SLX1 (0.973); EXO1 (0.967); RAD51 (0.963); DNA2 (0.954); MLH1 (0.954); RMI1 (0.952); TOP3 (0.945); MLH3 (0.94); RAD27 (0.916); SPO11 (0.906); RAD1 (0.904); MEC1 (0.901); CDC28 (0.9); SRS2 (0.891); RAD52 (0.887); RAD9 (0.885); DNL4 (0.867)
Homologues (species, bitscore): GEN1 (Homo sapiens, 77.8); Gen1 (Mus musculus, 73.2); GEN1 (Danio rerio, 60.5); gen1 (Xenopus tropicalis, 65.5); Mus201 (Drosophila melanogaster, 58.2); gen-1 (Caenorhabditis elegans, 59.7); UVH3 (Arabidopsis thaliana, 63.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:226517-228796:+ | gene-YER041W_AKU4011 | rna-NM_001178932.2_AKU4011 | cds-NP_010959.2_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000011.1:196917-199196:- | gene-YER041W_BG1 | rna-NM_001178932.2_BG1 | cds-NP_010959.2_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:235373-237652:+ | gene-YER041W_Bruggeman | rna-NM_001178932.2_Bruggeman | cds-NP_010959.2_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:229486-231765:+ | gene-YER041W_CAT1 | rna-NM_001178932.2_CAT1 | cds-NP_010959.2_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:226426-228705:+ | gene-YER041W_CBS1585 | rna-NM_001178932.2_CBS1585 | cds-NP_010959.2_CBS1585 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:228373-230652:+ | gene-YER041W_CBS436 | rna-NM_001178932.2_CBS436 | cds-NP_010959.2_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:226287-228566:+ | gene-YER041W_CBS6412 | rna-NM_001178932.2_CBS6412 | cds-NP_010959.2_CBS6412 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:231897-234176:+ | gene-YER041W_CBS6413 | rna-NM_001178932.2_CBS6413 | cds-NP_010959.2_CBS6413 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:230653-232932:+ | gene-YER041W_CENPK1137D | rna-NM_001178932.2_CENPK1137D | cds-NP_010959.2_CENPK1137D | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:227121-229400:+ | gene-YER041W_EthanolRed | rna-NM_001178932.2_EthanolRed | cds-NP_010959.2_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:227384-229663:+ | gene-YER041W_FaliES1 | rna-NM_001178932.2_FaliES1 | cds-NP_010959.2_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000192.1:25150-27429:+ | gene-YER041W_JAY291 | rna-NM_001178932.2_JAY291 | cds-NP_010959.2_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:230822-233101:+ | gene-YER041W_MUCL30387 | rna-NM_001178932.2_MUCL30387 | cds-NP_010959.2_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:227038-229317:+ | gene-YER041W_MUCL30388 | rna-NM_001178932.2_MUCL30388 | cds-NP_010959.2_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:225468-227747:+ | gene-YER041W_MUCL39482 | rna-NM_001178932.2_MUCL39482 | cds-NP_010959.2_MUCL39482 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:232544-234823:+ | gene-YER041W_MUCL42920 | rna-NM_001178932.2_MUCL42920 | cds-NP_010959.2_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:232460-234739:+ | gene-YER041W_NCIM3186 | rna-NM_001178932.2_NCIM3186 | cds-NP_010959.2_NCIM3186 | 90.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:230530-232809:+ | gene-YER041W_NCYC1407 | rna-NM_001178932.2_NCYC1407 | cds-NP_010959.2_NCYC1407 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:241162-243441:+ | gene-YER041W_PE2H3 | rna-NM_001178932.2_PE2H3 | cds-NP_010959.2_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:231103-233382:+ | gene-YER041W_PE2H4 | rna-NM_001178932.2_PE2H4 | cds-NP_010959.2_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:232461-234740:+ | gene-YER041W_S288C | rna-NM_001178932.2_S288C | cds-NP_010959.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000020.1:8949-11228:- | gene-YER041W_SA1 | rna-NM_001178932.2_SA1 | cds-NP_010959.2_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:228156-230435:+ | gene-YER041W_ThermosaccDry | rna-NM_001178932.2_ThermosaccDry | cds-NP_010959.2_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:227258-229537:+ | gene-YER041W_VR1 | rna-NM_001178932.2_VR1 | cds-NP_010959.2_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000009.1:225367-227646:+ | gene-YER041W_ZTW1 | rna-NM_001178932.2_ZTW1 | cds-NP_010959.2_ZTW1 | 99.3 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:229193-231478:+ | gene-YER041W_Sparadoxus | rna-NM_001178932.2_Sparadoxus | cds-NP_010959.2_Sparadoxus | 86.0 | 99.6 | Verified | 1 | 1 | 1 | False | True | False | False | False |