Gene name: YCF1
Reference locus (S288C): YDR135C
Gene biotype: protein_coding
Description: Metal resistance protein YCF1; Vacuolar glutathione S-conjugate transporter; ABC-C transporter of the ATP-binding cassette family; required for vacuole fusion; forms stable complexes with vacuole fusion machinery; regulates Vam7p recruitment to vacuoles; role in detoxifying metals (Cd, Hg, As); transports GSSG that is not immediately reduced in cytosol to vacuole; transports unconjugated bilirubin, selenodigluthatione, oxidized glutathione; similar to human cystic fibrosis protein CFTR
Top 10 interactors (score): ARR3 (0.98); ECM38 (0.978); GTT2 (0.974); GTT1 (0.95); ECM4 (0.913); BPT1 (0.91); URE2 (0.909); GTO1 (0.903); GTT3 (0.9); YOR1 (0.889); ARR2 (0.849); YAP1 (0.844); GLR1 (0.841); ARR1 (0.83); GSH1 (0.827); PDR11 (0.825); SNQ2 (0.818); ADP1 (0.813); PDR10 (0.78); ZRC1 (0.777)
Homologues (species, bitscore): ABCC1 (Homo sapiens, 1095.1); Abcc1 (Mus musculus, 1070.1); abcc2 (Danio rerio, 1038.5); abcc3 (Xenopus tropicalis, 1077.8); MRP (Drosophila melanogaster, 1009.6); mrp-1 (Caenorhabditis elegans, 1010.7); ABCC1 (Arabidopsis thaliana, 866.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:693938-698485:- | gene-YDR135C_AKU4011 | rna-NM_001180442.3_AKU4011 | cds-NP_010419.3_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000080.1:426354-430901:+ | gene-YDR135C_BG1 | rna-NM_001180442.3_BG1 | cds-NP_010419.3_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:725993-730540:- | gene-YDR135C_Bruggeman | rna-NM_001180442.3_Bruggeman | cds-NP_010419.3_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:713965-718512:- | gene-YDR135C_CAT1 | rna-NM_001180442.3_CAT1 | cds-NP_010419.3_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:684976-689523:- | gene-YDR135C_CBS1585 | rna-NM_001180442.3_CBS1585 | cds-NP_010419.3_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:710879-715426:- | gene-YDR135C_CBS436 | rna-NM_001180442.3_CBS436 | cds-NP_010419.3_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:681328-685875:- | gene-YDR135C_CBS6412 | rna-NM_001180442.3_CBS6412 | cds-NP_010419.3_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:710304-714851:- | gene-YDR135C_CBS6413 | rna-NM_001180442.3_CBS6413 | cds-NP_010419.3_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:715441-719988:- | gene-YDR135C_CENPK1137D | rna-NM_001180442.3_CENPK1137D | cds-NP_010419.3_CENPK1137D | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:695701-700248:- | gene-YDR135C_EthanolRed | rna-NM_001180442.3_EthanolRed | cds-NP_010419.3_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:702495-707042:- | gene-YDR135C_FaliES1 | rna-NM_001180442.3_FaliES1 | cds-NP_010419.3_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000002.1:54640-59187:- | gene-YDR135C_JAY291 | rna-NM_001180442.3_JAY291 | cds-NP_010419.3_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:711917-716464:- | gene-YDR135C_MUCL30387 | rna-NM_001180442.3_MUCL30387 | cds-NP_010419.3_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:700936-705483:- | gene-YDR135C_MUCL30388 | rna-NM_001180442.3_MUCL30388 | cds-NP_010419.3_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:686319-690866:- | gene-YDR135C_MUCL39482 | rna-NM_001180442.3_MUCL39482 | cds-NP_010419.3_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:624275-628822:- | gene-YDR135C_MUCL42920 | rna-NM_001180442.3_MUCL42920 | cds-NP_010419.3_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:722927-727474:- | gene-YDR135C_NCIM3186 | rna-NM_001180442.3_NCIM3186 | cds-NP_010419.3_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:685720-690267:- | gene-YDR135C_NCYC1407 | rna-NM_001180442.3_NCYC1407 | cds-NP_010419.3_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:705058-709605:- | gene-YDR135C_PE2H3 | rna-NM_001180442.3_PE2H3 | cds-NP_010419.3_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:704363-708910:- | gene-YDR135C_PE2H4 | rna-NM_001180442.3_PE2H4 | cds-NP_010419.3_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:723004-727551:- | gene-YDR135C_S288C | rna-NM_001180442.3_S288C | cds-NP_010419.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000009.1:71674-76221:- | gene-YDR135C_SA1 | rna-NM_001180442.3_SA1 | cds-NP_010419.3_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:702017-706564:- | gene-YDR135C_ThermosaccDry | rna-NM_001180442.3_ThermosaccDry | cds-NP_010419.3_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:715372-719919:- | gene-YDR135C_VR1 | rna-NM_001180442.3_VR1 | cds-NP_010419.3_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:699598-704145:- | gene-YDR135C_ZTW1 | rna-NM_001180442.3_ZTW1 | cds-NP_010419.3_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:704148-708698:- | gene-YDR135C_Sparadoxus | rna-NM_001180442.3_Sparadoxus | cds-NP_010419.3_Sparadoxus | 89.5 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |