Gene name: YAK1
Reference locus (S288C): YJL141C
Gene biotype: protein_coding
Description: Dual specificity protein kinase YAK1; Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit transcription of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose
Top 10 interactors (score): YPL247C (0.999); RGA1 (0.987); RGA2 (0.987); SMT3 (0.952); UBC9 (0.941); IRC9 (0.941); BCY1 (0.94); GLC3 (0.916); TPK1 (0.915); MSN2 (0.915); HSF1 (0.903); TPK2 (0.899); BUD14 (0.871); GSY2 (0.863); TPS2 (0.859); HSP42 (0.859); TSL1 (0.847); MSN4 (0.844); NTH1 (0.827); RAS2 (0.827)
Homologues (species, bitscore): HIPK3 (Homo sapiens, 271.9); Hipk2 (Mus musculus, 272.3); hipk2 (Danio rerio, 271.6); hipk2 (Xenopus tropicalis, 271.6); hipk (Drosophila melanogaster, 274.2); hpk-1 (Caenorhabditis elegans, 275.4); YAK1 (Arabidopsis thaliana, 410.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005304.1:136260-138686:- | gene-YJL141C_AKU4011 | rna-NM_001181574.1_AKU4011 | cds-NP_012394.1_AKU4011 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000190.1:475036-477459:+ | gene-YJL141C_BG1 | rna-NM_001181574.1_BG1 | cds-NP_012394.1_BG1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005512.1:148097-150520:- | gene-YJL141C_Bruggeman | rna-NM_001181574.1_Bruggeman | cds-NP_012394.1_Bruggeman | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005528.1:151885-154308:- | gene-YJL141C_CAT1 | rna-NM_001181574.1_CAT1 | cds-NP_012394.1_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005368.1:141894-144320:- | gene-YJL141C_CBS1585 | rna-NM_001181574.1_CBS1585 | cds-NP_012394.1_CBS1585 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005352.1:166647-169070:- | gene-YJL141C_CBS436 | rna-NM_001181574.1_CBS436 | cds-NP_012394.1_CBS436 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005336.1:138303-140732:- | gene-YJL141C_CBS6412 | rna-NM_001181574.1_CBS6412 | cds-NP_012394.1_CBS6412 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005320.1:139367-141796:- | gene-YJL141C_CBS6413 | rna-NM_001181574.1_CBS6413 | cds-NP_012394.1_CBS6413 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001531.1:130355-132778:- | gene-YJL141C_CENPK1137D | rna-NM_001181574.1_CENPK1137D | cds-NP_012394.1_CENPK1137D | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005480.1:140418-142844:- | gene-YJL141C_EthanolRed | rna-NM_001181574.1_EthanolRed | cds-NP_012394.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005544.1:145896-148322:- | gene-YJL141C_FaliES1 | rna-NM_001181574.1_FaliES1 | cds-NP_012394.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000099.1:27077-29500:- | gene-YJL141C_JAY291 | rna-NM_001181574.1_JAY291 | cds-NP_012394.1_JAY291 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005416.1:150366-152789:- | gene-YJL141C_MUCL30387 | rna-NM_001181574.1_MUCL30387 | cds-NP_012394.1_MUCL30387 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005448.1:146418-148841:- | gene-YJL141C_MUCL30388 | rna-NM_001181574.1_MUCL30388 | cds-NP_012394.1_MUCL30388 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005288.1:140636-143062:- | gene-YJL141C_MUCL39482 | rna-NM_001181574.1_MUCL39482 | cds-NP_012394.1_MUCL39482 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005432.1:146157-148580:- | gene-YJL141C_MUCL42920 | rna-NM_001181574.1_MUCL42920 | cds-NP_012394.1_MUCL42920 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011819.1:147946-150369:- | gene-YJL141C_NCIM3186 | rna-NM_001181574.1_NCIM3186 | cds-NP_012394.1_NCIM3186 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005272.1:139245-141674:- | gene-YJL141C_NCYC1407 | rna-NM_001181574.1_NCYC1407 | cds-NP_012394.1_NCYC1407 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994149.1:152054-154477:- | gene-YJL141C_PE2H3 | rna-NM_001181574.1_PE2H3 | cds-NP_012394.1_PE2H3 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999881.1:151697-154120:- | gene-YJL141C_PE2H4 | rna-NM_001181574.1_PE2H4 | cds-NP_012394.1_PE2H4 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001142.9:147967-150390:- | gene-YJL141C_S288C | rna-NM_001181574.1_S288C | cds-NP_012394.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000022.1:3224-5647:+ | gene-YJL141C_SA1 | rna-NM_001181574.1_SA1 | cds-NP_012394.1_SA1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005496.1:139087-141513:- | gene-YJL141C_ThermosaccDry | rna-NM_001181574.1_ThermosaccDry | cds-NP_012394.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005464.1:146171-148594:- | gene-YJL141C_VR1 | rna-NM_001181574.1_VR1 | cds-NP_012394.1_VR1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000021.1:126376-128802:- | gene-YJL141C_ZTW1 | rna-NM_001181574.1_ZTW1 | cds-NP_012394.1_ZTW1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047496.1:151677-154085:- | gene-YJL141C_Sparadoxus | rna-NM_001181574.1_Sparadoxus | cds-NP_012394.1_Sparadoxus | 88.7 | 99.3 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |