Gene name: VPS74
Reference locus (S288C): YDR372C
Gene biotype: protein_coding
Description: Vacuolar protein sorting-associated protein 74; Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33; Belongs to the GOLPH3/VPS74 family
Top 10 interactors (score): SAC1 (0.997); KRE2 (0.869); MNN5 (0.811); VPS35 (0.765); MNN2 (0.746); PIK1 (0.739); KTR6 (0.714); BDP1 (0.713); KTR3 (0.711); ACP1 (0.709); MNN4 (0.698); API2 (0.695); RPC34 (0.69); LSG1 (0.69); LSB6 (0.689); YPT6 (0.677); ARF1 (0.667); SEC16 (0.665); YHI9 (0.659); HSP60 (0.657)
Homologues (species, bitscore): GOLPH3L (Homo sapiens, 195.7); Golph3 (Mus musculus, 193.4); golph3l (Danio rerio, 194.9); golph3l (Xenopus tropicalis, 195.7); sau (Drosophila melanogaster, 191.0); Y47G6A.18 (Caenorhabditis elegans, 185.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:1161256-1162293:- | gene-YDR372C_AKU4011 | rna-NM_001180680.1_AKU4011 | cds-NP_010660.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000039.1:39804-40841:- | gene-YDR372C_BG1 | rna-NM_001180680.1_BG1 | cds-NP_010660.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:1191887-1192924:- | gene-YDR372C_Bruggeman | rna-NM_001180680.1_Bruggeman | cds-NP_010660.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:1170498-1171535:- | gene-YDR372C_CAT1 | rna-NM_001180680.1_CAT1 | cds-NP_010660.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:1155973-1157010:- | gene-YDR372C_CBS1585 | rna-NM_001180680.1_CBS1585 | cds-NP_010660.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:1174555-1175592:- | gene-YDR372C_CBS436 | rna-NM_001180680.1_CBS436 | cds-NP_010660.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:1152233-1153270:- | gene-YDR372C_CBS6412 | rna-NM_001180680.1_CBS6412 | cds-NP_010660.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:1174123-1175160:- | gene-YDR372C_CBS6413 | rna-NM_001180680.1_CBS6413 | cds-NP_010660.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:1219764-1220801:- | gene-YDR372C_CENPK1137D | rna-NM_001180680.1_CENPK1137D | cds-NP_010660.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:1165657-1166694:- | gene-YDR372C_EthanolRed | rna-NM_001180680.1_EthanolRed | cds-NP_010660.1_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:1168940-1169977:- | gene-YDR372C_FaliES1 | rna-NM_001180680.1_FaliES1 | cds-NP_010660.1_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000057.1:21099-22136:+ | gene-YDR372C_JAY291 | rna-NM_001180680.1_JAY291 | cds-NP_010660.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:1175205-1176242:- | gene-YDR372C_MUCL30387 | rna-NM_001180680.1_MUCL30387 | cds-NP_010660.1_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:1157810-1158847:- | gene-YDR372C_MUCL30388 | rna-NM_001180680.1_MUCL30388 | cds-NP_010660.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:1147507-1148544:- | gene-YDR372C_MUCL39482 | rna-NM_001180680.1_MUCL39482 | cds-NP_010660.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:1089937-1090974:- | gene-YDR372C_MUCL42920 | rna-NM_001180680.1_MUCL42920 | cds-NP_010660.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:1221035-1222072:- | gene-YDR372C_NCIM3186 | rna-NM_001180680.1_NCIM3186 | cds-NP_010660.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:1161178-1162215:- | gene-YDR372C_NCYC1407 | rna-NM_001180680.1_NCYC1407 | cds-NP_010660.1_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:1171604-1172641:- | gene-YDR372C_PE2H3 | rna-NM_001180680.1_PE2H3 | cds-NP_010660.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:1177189-1178226:- | gene-YDR372C_PE2H4 | rna-NM_001180680.1_PE2H4 | cds-NP_010660.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:1221112-1222149:- | gene-YDR372C_S288C | rna-NM_001180680.1_S288C | cds-NP_010660.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000072.1:39885-40922:- | gene-YDR372C_SA1 | rna-NM_001180680.1_SA1 | cds-NP_010660.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:1173221-1174258:- | gene-YDR372C_ThermosaccDry | rna-NM_001180680.1_ThermosaccDry | cds-NP_010660.1_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:600568-601605:- | gene-YDR372C_VR1 | rna-NM_001180680.1_VR1 | cds-NP_010660.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000008.1:216054-217091:- | gene-YDR372C_ZTW1 | rna-NM_001180680.1_ZTW1 | cds-NP_010660.1_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:1167729-1168772:- | gene-YDR372C_Sparadoxus | rna-NM_001180680.1_Sparadoxus | cds-NP_010660.1_Sparadoxus | 92.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |