Gene name: VPS41
Reference locus (S288C): YDR080W
Gene biotype: protein_coding
Description: Vacuolar protein sorting-associated protein 41; Subunit of the HOPS endocytic tethering complex; vacuole membrane protein that functions as a Rab GTPase effector, interacting specifically with the GTP-bound conformation of Ypt7p, facilitating tethering, docking and promoting membrane fusion events at the late endosome and vacuole; required for both membrane and protein trafficking; Yck3p-mediated phosphorylation regulates the organization of vacuolar fusion sites
Top 10 interactors (score): PEP5 (0.999); PEP3 (0.999); VPS33 (0.999); VAM3 (0.999); VAM7 (0.999); YPT7 (0.999); VAM6 (0.999); VPS3 (0.999); VTI1 (0.999); VPS16 (0.999); VPS8 (0.993); YCK3 (0.964); APL5 (0.961); YPT52 (0.951); SEC1 (0.937); VMA1 (0.932); NYV1 (0.919); YKT6 (0.911); MON1 (0.89); VPS45 (0.879)
Homologues (species, bitscore): VPS41 (Homo sapiens, 243.0); Vps41 (Mus musculus, 237.7); vps41 (Danio rerio, 241.9); vps41 (Xenopus tropicalis, 236.9); lt (Drosophila melanogaster, 147.5); vps-41 (Caenorhabditis elegans, 129.0); VPS41 (Arabidopsis thaliana, 214.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:581560-584550:+ | gene-YDR080W_AKU4011 | rna-NM_001180388.3_AKU4011 | cds-NP_010365.3_AKU4011 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000080.1:540799-543777:- | gene-YDR080W_BG1 | rna-NM_001180388.3_BG1 | cds-NP_010365.3_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:613791-616778:+ | gene-YDR080W_Bruggeman | rna-NM_001180388.3_Bruggeman | cds-NP_010365.3_Bruggeman | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:597435-600413:+ | gene-YDR080W_CAT1 | rna-NM_001180388.3_CAT1 | cds-NP_010365.3_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:572576-575569:+ | gene-YDR080W_CBS1585 | rna-NM_001180388.3_CBS1585 | cds-NP_010365.3_CBS1585 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:597607-600585:+ | gene-YDR080W_CBS436 | rna-NM_001180388.3_CBS436 | cds-NP_010365.3_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:568991-571984:+ | gene-YDR080W_CBS6412 | rna-NM_001180388.3_CBS6412 | cds-NP_010365.3_CBS6412 | 98.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:597524-600514:+ | gene-YDR080W_CBS6413 | rna-NM_001180388.3_CBS6413 | cds-NP_010365.3_CBS6413 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:603019-605997:+ | gene-YDR080W_CENPK1137D | rna-NM_001180388.3_CENPK1137D | cds-NP_010365.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:583350-586340:+ | gene-YDR080W_EthanolRed | rna-NM_001180388.3_EthanolRed | cds-NP_010365.3_EthanolRed | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:590144-593134:+ | gene-YDR080W_FaliES1 | rna-NM_001180388.3_FaliES1 | cds-NP_010365.3_FaliES1 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000358.1:38138-41116:- | gene-YDR080W_JAY291 | rna-NM_001180388.3_JAY291 | cds-NP_010365.3_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:598408-601395:+ | gene-YDR080W_MUCL30387 | rna-NM_001180388.3_MUCL30387 | cds-NP_010365.3_MUCL30387 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:588720-591707:+ | gene-YDR080W_MUCL30388 | rna-NM_001180388.3_MUCL30388 | cds-NP_010365.3_MUCL30388 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:573946-576939:+ | gene-YDR080W_MUCL39482 | rna-NM_001180388.3_MUCL39482 | cds-NP_010365.3_MUCL39482 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:504528-507515:+ | gene-YDR080W_MUCL42920 | rna-NM_001180388.3_MUCL42920 | cds-NP_010365.3_MUCL42920 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:603931-606909:+ | gene-YDR080W_NCIM3186 | rna-NM_001180388.3_NCIM3186 | cds-NP_010365.3_NCIM3186 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:572871-575846:+ | gene-YDR080W_NCYC1407 | rna-NM_001180388.3_NCYC1407 | cds-NP_010365.3_NCYC1407 | 99.1 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:592332-595310:+ | gene-YDR080W_PE2H3 | rna-NM_001180388.3_PE2H3 | cds-NP_010365.3_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:591637-594615:+ | gene-YDR080W_PE2H4 | rna-NM_001180388.3_PE2H4 | cds-NP_010365.3_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:604008-606986:+ | gene-YDR080W_S288C | rna-NM_001180388.3_S288C | cds-NP_010365.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000011.1:38345-41323:- | gene-YDR080W_SA1 | rna-NM_001180388.3_SA1 | cds-NP_010365.3_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:589675-592665:+ | gene-YDR080W_ThermosaccDry | rna-NM_001180388.3_ThermosaccDry | cds-NP_010365.3_ThermosaccDry | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:602236-605214:+ | gene-YDR080W_VR1 | rna-NM_001180388.3_VR1 | cds-NP_010365.3_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:587247-590252:+ | gene-YDR080W_ZTW1 | rna-NM_001180388.3_ZTW1 | cds-NP_010365.3_ZTW1 | 98.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:591906-594902:+ | gene-YDR080W_Sparadoxus | rna-NM_001180388.3_Sparadoxus | cds-NP_010365.3_Sparadoxus | 89.1 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |