Gene name: VPS4
Reference locus (S288C): YPR173C
Gene biotype: protein_coding
Description: AAA-ATPase involved in multivesicular body (MVB) protein sorting; ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism
Top 10 interactors (score): VPS20 (0.999); DID2 (0.999); IST1 (0.999); DID4 (0.999); SNF7 (0.999); VPS60 (0.999); VTA1 (0.999); VPS24 (0.998); BRO1 (0.992); STP22 (0.977); VPS27 (0.976); VPS28 (0.963); VPS36 (0.96); VFA1 (0.959); DOA4 (0.955); VPS25 (0.926); RIM20 (0.905); OSH7 (0.887); VPS21 (0.854); OSH6 (0.819)
Homologues (species, bitscore): VPS4B (Homo sapiens, 528.9); Vps4b (Mus musculus, 527.3); vps4b (Danio rerio, 526.2); vps4a (Xenopus tropicalis, 525.0); Vps4 (Drosophila melanogaster, 515.4); vps-4 (Caenorhabditis elegans, 498.8); SKD1 (Arabidopsis thaliana, 467.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:840803-842116:- | gene-YPR173C_AKU4011 | rna-NM_001184270.1_AKU4011 | cds-NP_015499.1_AKU4011 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000091.1:55594-56907:+ | gene-YPR173C_BG1 | rna-NM_001184270.1_BG1 | cds-NP_015499.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:922087-923400:- | gene-YPR173C_Bruggeman | rna-NM_001184270.1_Bruggeman | cds-NP_015499.1_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:964144-965457:- | gene-YPR173C_CAT1 | rna-NM_001184270.1_CAT1 | cds-NP_015499.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:845605-846918:- | gene-YPR173C_CBS1585 | rna-NM_001184270.1_CBS1585 | cds-NP_015499.1_CBS1585 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:859151-860464:- | gene-YPR173C_CBS436 | rna-NM_001184270.1_CBS436 | cds-NP_015499.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:847389-848702:- | gene-YPR173C_CBS6412 | rna-NM_001184270.1_CBS6412 | cds-NP_015499.1_CBS6412 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:842533-843846:- | gene-YPR173C_CBS6413 | rna-NM_001184270.1_CBS6413 | cds-NP_015499.1_CBS6413 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:886611-887924:- | gene-YPR173C_CENPK1137D | rna-NM_001184270.1_CENPK1137D | cds-NP_015499.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:1162565-1163878:- | gene-YPR173C_EthanolRed | rna-NM_001184270.1_EthanolRed | cds-NP_015499.1_EthanolRed | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:842638-843951:- | gene-YPR173C_FaliES1 | rna-NM_001184270.1_FaliES1 | cds-NP_015499.1_FaliES1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000081.1:29930-31243:- | gene-YPR173C_JAY291 | rna-NM_001184270.1_JAY291 | cds-NP_015499.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:889333-890646:- | gene-YPR173C_MUCL30387 | rna-NM_001184270.1_MUCL30387 | cds-NP_015499.1_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:863462-864775:- | gene-YPR173C_MUCL30388 | rna-NM_001184270.1_MUCL30388 | cds-NP_015499.1_MUCL30388 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:837805-839118:- | gene-YPR173C_MUCL39482 | rna-NM_001184270.1_MUCL39482 | cds-NP_015499.1_MUCL39482 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:902275-903588:- | gene-YPR173C_MUCL42920 | rna-NM_001184270.1_MUCL42920 | cds-NP_015499.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:886507-887820:- | gene-YPR173C_NCIM3186 | rna-NM_001184270.1_NCIM3186 | cds-NP_015499.1_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:846166-847479:- | gene-YPR173C_NCYC1407 | rna-NM_001184270.1_NCYC1407 | cds-NP_015499.1_NCYC1407 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:858454-859767:- | gene-YPR173C_PE2H3 | rna-NM_001184270.1_PE2H3 | cds-NP_015499.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:858102-859415:- | gene-YPR173C_PE2H4 | rna-NM_001184270.1_PE2H4 | cds-NP_015499.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:886524-887837:- | gene-YPR173C_S288C | rna-NM_001184270.1_S288C | cds-NP_015499.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000060.1:37977-39290:+ | gene-YPR173C_SA1 | rna-NM_001184270.1_SA1 | cds-NP_015499.1_SA1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:842326-843639:- | gene-YPR173C_ThermosaccDry | rna-NM_001184270.1_ThermosaccDry | cds-NP_015499.1_ThermosaccDry | 99.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:870109-871422:- | gene-YPR173C_VR1 | rna-NM_001184270.1_VR1 | cds-NP_015499.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:844876-846189:- | gene-YPR173C_ZTW1 | rna-NM_001184270.1_ZTW1 | cds-NP_015499.1_ZTW1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:846943-848256:- | gene-YPR173C_Sparadoxus | rna-NM_001184270.1_Sparadoxus | cds-NP_015499.1_Sparadoxus | 92.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |