Gene name: VPS35
Reference locus (S288C): YJL154C
Gene biotype: protein_coding
Description: Vacuolar protein sorting-associated protein 35; Endosomal subunit of membrane-associated retromer complex; required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p; overexpression of wild-type human VPS35 or Parkinson's-associated vps35-D686N or vps35-P299S variants complements Ni2+ resistance and Cd2+ sensitivity of yeast vps35 null mutant
Top 10 interactors (score): VPS5 (0.999); SNX3 (0.999); VPS17 (0.999); VPS29 (0.999); PEP8 (0.999); YPT7 (0.999); PEP1 (0.996); YKR078W (0.987); MVP1 (0.987); SNX4 (0.96); YPT6 (0.959); VPS54 (0.954); SNX41 (0.935); VPS36 (0.933); VPS13 (0.924); VPS27 (0.923); CHC1 (0.922); ATG20 (0.912); VPS9 (0.911); VMA6 (0.899)
Homologues (species, bitscore): VPS35 (Homo sapiens, 426.0); Vps35 (Mus musculus, 424.9); vps35 (Danio rerio, 434.1); vps35 (Xenopus tropicalis, 419.5); Vps35 (Drosophila melanogaster, 392.1); vps-35 (Caenorhabditis elegans, 347.8); VPS35B (Arabidopsis thaliana, 399.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005304.1:119402-122236:- | gene-YJL154C_AKU4011 | rna-NM_001181587.1_AKU4011 | cds-NP_012381.1_AKU4011 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000190.1:491477-494311:+ | gene-YJL154C_BG1 | rna-NM_001181587.1_BG1 | cds-NP_012381.1_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005512.1:131235-134069:- | gene-YJL154C_Bruggeman | rna-NM_001181587.1_Bruggeman | cds-NP_012381.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005528.1:135024-137858:- | gene-YJL154C_CAT1 | rna-NM_001181587.1_CAT1 | cds-NP_012381.1_CAT1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005368.1:125037-127871:- | gene-YJL154C_CBS1585 | rna-NM_001181587.1_CBS1585 | cds-NP_012381.1_CBS1585 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005352.1:149799-152633:- | gene-YJL154C_CBS436 | rna-NM_001181587.1_CBS436 | cds-NP_012381.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005336.1:121446-124280:- | gene-YJL154C_CBS6412 | rna-NM_001181587.1_CBS6412 | cds-NP_012381.1_CBS6412 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005320.1:122509-125343:- | gene-YJL154C_CBS6413 | rna-NM_001181587.1_CBS6413 | cds-NP_012381.1_CBS6413 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001531.1:113500-116334:- | gene-YJL154C_CENPK1137D | rna-NM_001181587.1_CENPK1137D | cds-NP_012381.1_CENPK1137D | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005480.1:123562-126396:- | gene-YJL154C_EthanolRed | rna-NM_001181587.1_EthanolRed | cds-NP_012381.1_EthanolRed | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005544.1:129039-131873:- | gene-YJL154C_FaliES1 | rna-NM_001181587.1_FaliES1 | cds-NP_012381.1_FaliES1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000099.1:10220-13054:- | gene-YJL154C_JAY291 | rna-NM_001181587.1_JAY291 | cds-NP_012381.1_JAY291 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005416.1:133059-136337:- | gene-YJL154C_MUCL30387 | rna-NM_001181587.1_MUCL30387 | cds-NP_012381.1_MUCL30387 | 86.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005448.1:129537-132371:- | gene-YJL154C_MUCL30388 | rna-NM_001181587.1_MUCL30388 | cds-NP_012381.1_MUCL30388 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005288.1:123779-126613:- | gene-YJL154C_MUCL39482 | rna-NM_001181587.1_MUCL39482 | cds-NP_012381.1_MUCL39482 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005432.1:129060-131894:- | gene-YJL154C_MUCL42920 | rna-NM_001181587.1_MUCL42920 | cds-NP_012381.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011819.1:131080-133914:- | gene-YJL154C_NCIM3186 | rna-NM_001181587.1_NCIM3186 | cds-NP_012381.1_NCIM3186 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005272.1:122387-125221:- | gene-YJL154C_NCYC1407 | rna-NM_001181587.1_NCYC1407 | cds-NP_012381.1_NCYC1407 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994149.1:135202-138036:- | gene-YJL154C_PE2H3 | rna-NM_001181587.1_PE2H3 | cds-NP_012381.1_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999881.1:134840-137674:- | gene-YJL154C_PE2H4 | rna-NM_001181587.1_PE2H4 | cds-NP_012381.1_PE2H4 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001142.9:131101-133935:- | gene-YJL154C_S288C | rna-NM_001181587.1_S288C | cds-NP_012381.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000022.1:19662-22496:+ | gene-YJL154C_SA1 | rna-NM_001181587.1_SA1 | cds-NP_012381.1_SA1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005496.1:122230-125064:- | gene-YJL154C_ThermosaccDry | rna-NM_001181587.1_ThermosaccDry | cds-NP_012381.1_ThermosaccDry | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005464.1:129318-132152:- | gene-YJL154C_VR1 | rna-NM_001181587.1_VR1 | cds-NP_012381.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000021.1:109682-112517:- | gene-YJL154C_ZTW1 | rna-NM_001181587.1_ZTW1 | cds-NP_012381.1_ZTW1 | 99.6 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047496.1:134818-137652:- | gene-YJL154C_Sparadoxus | rna-NM_001181587.1_Sparadoxus | cds-NP_012381.1_Sparadoxus | 90.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |