Gene name: VPS30
Reference locus (S288C): YPL120W
Gene biotype: protein_coding
Description: Vacuolar protein sorting-associated protein 30; Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy, Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; C-terminus has novel globular fold essential for autophagy through the targeting of the PI3-kinase complex I to the pre-autophagosomal structure; ortholog of higher eukaryote gene Beclin 1; human BECN1 can complement yeast null mutant
Top 10 interactors (score): ATG3 (0.999); ATG1 (0.999); VPS34 (0.999); ATG8 (0.999); VPS38 (0.999); ATG18 (0.999); ATG9 (0.999); ATG12 (0.999); ATG14 (0.999); VPS15 (0.999); ATG38 (0.997); ATG4 (0.997); ATG7 (0.997); ATG5 (0.994); ATG11 (0.992); ATG2 (0.992); ATG13 (0.988); FAB1 (0.984); ATG21 (0.973); ATG16 (0.961)
Homologues (species, bitscore): BECN1 (Homo sapiens, 156.8); Becn1 (Mus musculus, 156.0); becn1 (Danio rerio, 149.8); becn1 (Xenopus tropicalis, 156.0); Atg6 (Drosophila melanogaster, 157.5); bec-1 (Caenorhabditis elegans, 82.0); ATG6 (Arabidopsis thaliana, 140.6)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:299713-301386:+ | gene-YPL120W_AKU4011 | rna-NM_001183934.1_AKU4011 | cds-NP_015205.1_AKU4011 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000069.1:505469-507142:+ | gene-YPL120W_BG1 | rna-NM_001183934.1_BG1 | cds-NP_015205.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:325716-327389:+ | gene-YPL120W_Bruggeman | rna-NM_001183934.1_Bruggeman | cds-NP_015205.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:322383-324056:+ | gene-YPL120W_CAT1 | rna-NM_001183934.1_CAT1 | cds-NP_015205.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:303786-305459:+ | gene-YPL120W_CBS1585 | rna-NM_001183934.1_CBS1585 | cds-NP_015205.1_CBS1585 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:318459-320132:+ | gene-YPL120W_CBS436 | rna-NM_001183934.1_CBS436 | cds-NP_015205.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:308455-310128:+ | gene-YPL120W_CBS6412 | rna-NM_001183934.1_CBS6412 | cds-NP_015205.1_CBS6412 | 99.0 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:300422-302095:+ | gene-YPL120W_CBS6413 | rna-NM_001183934.1_CBS6413 | cds-NP_015205.1_CBS6413 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:322004-323677:+ | gene-YPL120W_CENPK1137D | rna-NM_001183934.1_CENPK1137D | cds-NP_015205.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:298403-300076:+ | gene-YPL120W_EthanolRed | rna-NM_001183934.1_EthanolRed | cds-NP_015205.1_EthanolRed | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:305995-307668:+ | gene-YPL120W_FaliES1 | rna-NM_001183934.1_FaliES1 | cds-NP_015205.1_FaliES1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000007.1:58151-59824:- | gene-YPL120W_JAY291 | rna-NM_001183934.1_JAY291 | cds-NP_015205.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:316956-318629:+ | gene-YPL120W_MUCL30387 | rna-NM_001183934.1_MUCL30387 | cds-NP_015205.1_MUCL30387 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:314976-316649:+ | gene-YPL120W_MUCL30388 | rna-NM_001183934.1_MUCL30388 | cds-NP_015205.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:297115-298788:+ | gene-YPL120W_MUCL39482 | rna-NM_001183934.1_MUCL39482 | cds-NP_015205.1_MUCL39482 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:354358-356031:+ | gene-YPL120W_MUCL42920 | rna-NM_001183934.1_MUCL42920 | cds-NP_015205.1_MUCL42920 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:322054-323727:+ | gene-YPL120W_NCIM3186 | rna-NM_001183934.1_NCIM3186 | cds-NP_015205.1_NCIM3186 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:303568-305241:+ | gene-YPL120W_NCYC1407 | rna-NM_001183934.1_NCYC1407 | cds-NP_015205.1_NCYC1407 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:311058-312731:+ | gene-YPL120W_PE2H3 | rna-NM_001183934.1_PE2H3 | cds-NP_015205.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:310681-312354:+ | gene-YPL120W_PE2H4 | rna-NM_001183934.1_PE2H4 | cds-NP_015205.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:322071-323744:+ | gene-YPL120W_S288C | rna-NM_001183934.1_S288C | cds-NP_015205.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000012.1:49936-51609:- | gene-YPL120W_SA1 | rna-NM_001183934.1_SA1 | cds-NP_015205.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:305793-307466:+ | gene-YPL120W_ThermosaccDry | rna-NM_001183934.1_ThermosaccDry | cds-NP_015205.1_ThermosaccDry | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:320770-322443:+ | gene-YPL120W_VR1 | rna-NM_001183934.1_VR1 | cds-NP_015205.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:305118-306791:+ | gene-YPL120W_ZTW1 | rna-NM_001183934.1_ZTW1 | cds-NP_015205.1_ZTW1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:306860-308533:+ | gene-YPL120W_Sparadoxus | rna-NM_001183934.1_Sparadoxus | cds-NP_015205.1_Sparadoxus | 88.7 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |