Gene name: VPS21
Reference locus (S288C): YOR089C
Gene biotype: protein_coding
Description: Vacuolar protein sorting-associated protein 21; Endosomal Rab family GTPase; required for endocytic transport and sorting of vacuolar hydrolases; required for endosomal localization of the CORVET complex; required with YPT52 for MVB biogenesis and sorting; involved in autophagy and ionic stress tolerance; geranylgeranylation required for membrane association; protein abundance increases in response to DNA replication stress; mammalian Rab5 homolog; VPS21 has a paralog, YPT53, that arose from the whole genome duplication
Top 10 interactors (score): VPS3 (0.999); VPS9 (0.999); VAM6 (0.999); VPS8 (0.999); PEP5 (0.999); PEP7 (0.997); GDI1 (0.993); VPS34 (0.985); YPT52 (0.982); MRS6 (0.981); VPS45 (0.967); MON1 (0.957); PEP12 (0.949); PEP3 (0.938); MSB3 (0.938); VPS33 (0.937); YPT7 (0.935); VPS16 (0.933); VPS27 (0.927); MUK1 (0.882)
Homologues (species, bitscore): RAB5B (Homo sapiens, 215.7); Rab5b (Mus musculus, 215.7); rab5b (Danio rerio, 219.2); mras (Xenopus tropicalis, 219.9); Rab5 (Drosophila melanogaster, 215.7); rab-5 (Caenorhabditis elegans, 215.3); ARA6 (Arabidopsis thaliana, 195.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:474549-475181:- | gene-YOR089C_AKU4011 | rna-NM_001183508.1_AKU4011 | cds-NP_014732.1_AKU4011 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000171.1:104147-104779:+ | gene-YOR089C_BG1 | rna-NM_001183508.1_BG1 | cds-NP_014732.1_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:477860-478492:- | gene-YOR089C_Bruggeman | rna-NM_001183508.1_Bruggeman | cds-NP_014732.1_Bruggeman | 99.2 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:476394-477026:- | gene-YOR089C_CAT1 | rna-NM_001183508.1_CAT1 | cds-NP_014732.1_CAT1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:469841-470473:- | gene-YOR089C_CBS1585 | rna-NM_001183508.1_CBS1585 | cds-NP_014732.1_CBS1585 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:474595-475227:- | gene-YOR089C_CBS436 | rna-NM_001183508.1_CBS436 | cds-NP_014732.1_CBS436 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:468582-469214:- | gene-YOR089C_CBS6412 | rna-NM_001183508.1_CBS6412 | cds-NP_014732.1_CBS6412 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:475877-476509:- | gene-YOR089C_CBS6413 | rna-NM_001183508.1_CBS6413 | cds-NP_014732.1_CBS6413 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:490222-490854:- | gene-YOR089C_CENPK1137D | rna-NM_001183508.1_CENPK1137D | cds-NP_014732.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:471080-471712:- | gene-YOR089C_EthanolRed | rna-NM_001183508.1_EthanolRed | cds-NP_014732.1_EthanolRed | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:474587-475219:- | gene-YOR089C_FaliES1 | rna-NM_001183508.1_FaliES1 | cds-NP_014732.1_FaliES1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000063.1:84296-84928:+ | gene-YOR089C_JAY291 | rna-NM_001183508.1_JAY291 | cds-NP_014732.1_JAY291 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:482395-483027:- | gene-YOR089C_MUCL30387 | rna-NM_001183508.1_MUCL30387 | cds-NP_014732.1_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:487150-487782:- | gene-YOR089C_MUCL30388 | rna-NM_001183508.1_MUCL30388 | cds-NP_014732.1_MUCL30388 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:477477-478109:- | gene-YOR089C_MUCL39482 | rna-NM_001183508.1_MUCL39482 | cds-NP_014732.1_MUCL39482 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:493301-493933:- | gene-YOR089C_MUCL42920 | rna-NM_001183508.1_MUCL42920 | cds-NP_014732.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:490085-490717:- | gene-YOR089C_NCIM3186 | rna-NM_001183508.1_NCIM3186 | cds-NP_014732.1_NCIM3186 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:483658-484290:- | gene-YOR089C_NCYC1407 | rna-NM_001183508.1_NCYC1407 | cds-NP_014732.1_NCYC1407 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:482669-483301:- | gene-YOR089C_PE2H3 | rna-NM_001183508.1_PE2H3 | cds-NP_014732.1_PE2H3 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:493045-493677:- | gene-YOR089C_PE2H4 | rna-NM_001183508.1_PE2H4 | cds-NP_014732.1_PE2H4 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:490196-490828:- | gene-YOR089C_S288C | rna-NM_001183508.1_S288C | cds-NP_014732.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000098.1:31979-32611:+ | gene-YOR089C_SA1 | rna-NM_001183508.1_SA1 | cds-NP_014732.1_SA1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:473743-474375:- | gene-YOR089C_ThermosaccDry | rna-NM_001183508.1_ThermosaccDry | cds-NP_014732.1_ThermosaccDry | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:475589-476221:- | gene-YOR089C_VR1 | rna-NM_001183508.1_VR1 | cds-NP_014732.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000032.1:207740-208372:- | gene-YOR089C_ZTW1 | rna-NM_001183508.1_ZTW1 | cds-NP_014732.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:479510-480142:- | gene-YOR089C_Sparadoxus | rna-NM_001183508.1_Sparadoxus | cds-NP_014732.1_Sparadoxus | 93.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |