Gene name: VMS1
Reference locus (S288C): YDR049W
Gene biotype: protein_coding
Description: Protein VMS1; Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their ubiquitination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans; Belongs to the ANKZF1/VMS1 family
Top 10 interactors (score): CDC48 (0.999); NPL4 (0.994); RQC2 (0.985); UFD2 (0.955); RQC1 (0.95); DOA1 (0.947); TOM70 (0.941); UFD4 (0.925); UFD1 (0.921); TOM22 (0.914); SAM35 (0.912); TOM40 (0.911); SAM37 (0.907); MMM1 (0.904); YKR023W (0.9); TOM20 (0.9); TOM5 (0.9); SAM50 (0.9); TOM7 (0.9); RKR1 (0.887)
Homologues (species, bitscore): ANKZF1 (Homo sapiens, 128.3); Ankzf1 (Mus musculus, 121.3); ankzf1 (Danio rerio, 143.3); ankzf1 (Xenopus tropicalis, 108.6); vms-1 (Caenorhabditis elegans, 128.3); AT1G01930 (Arabidopsis thaliana, 151.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:530784-532682:+ | gene-YDR049W_AKU4011 | rna-NM_001180357.1_AKU4011 | cds-NP_010334.1_AKU4011 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:22525-24423:- | gene-YDR049W_BG1 | rna-NM_001180357.1_BG1 | cds-NP_010334.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:563132-565030:+ | gene-YDR049W_Bruggeman | rna-NM_001180357.1_Bruggeman | cds-NP_010334.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:546136-548034:+ | gene-YDR049W_CAT1 | rna-NM_001180357.1_CAT1 | cds-NP_010334.1_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:521740-523638:+ | gene-YDR049W_CBS1585 | rna-NM_001180357.1_CBS1585 | cds-NP_010334.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:546910-548808:+ | gene-YDR049W_CBS436 | rna-NM_001180357.1_CBS436 | cds-NP_010334.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:518152-520050:+ | gene-YDR049W_CBS6412 | rna-NM_001180357.1_CBS6412 | cds-NP_010334.1_CBS6412 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:546821-548719:+ | gene-YDR049W_CBS6413 | rna-NM_001180357.1_CBS6413 | cds-NP_010334.1_CBS6413 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:552211-554109:+ | gene-YDR049W_CENPK1137D | rna-NM_001180357.1_CENPK1137D | cds-NP_010334.1_CENPK1137D | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:532612-534510:+ | gene-YDR049W_EthanolRed | rna-NM_001180357.1_EthanolRed | cds-NP_010334.1_EthanolRed | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:539052-540950:+ | gene-YDR049W_FaliES1 | rna-NM_001180357.1_FaliES1 | cds-NP_010334.1_FaliES1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000246.1:13759-15657:- | gene-YDR049W_JAY291 | rna-NM_001180357.1_JAY291 | cds-NP_010334.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:547796-549694:+ | gene-YDR049W_MUCL30387 | rna-NM_001180357.1_MUCL30387 | cds-NP_010334.1_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:538213-540111:+ | gene-YDR049W_MUCL30388 | rna-NM_001180357.1_MUCL30388 | cds-NP_010334.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:523111-525009:+ | gene-YDR049W_MUCL39482 | rna-NM_001180357.1_MUCL39482 | cds-NP_010334.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:453341-455239:+ | gene-YDR049W_MUCL42920 | rna-NM_001180357.1_MUCL42920 | cds-NP_010334.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:553177-555075:+ | gene-YDR049W_NCIM3186 | rna-NM_001180357.1_NCIM3186 | cds-NP_010334.1_NCIM3186 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:522046-523944:+ | gene-YDR049W_NCYC1407 | rna-NM_001180357.1_NCYC1407 | cds-NP_010334.1_NCYC1407 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:541678-543576:+ | gene-YDR049W_PE2H3 | rna-NM_001180357.1_PE2H3 | cds-NP_010334.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:540983-542881:+ | gene-YDR049W_PE2H4 | rna-NM_001180357.1_PE2H4 | cds-NP_010334.1_PE2H4 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:553254-555152:+ | gene-YDR049W_S288C | rna-NM_001180357.1_S288C | cds-NP_010334.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000011.1:90338-92236:- | gene-YDR049W_SA1 | rna-NM_001180357.1_SA1 | cds-NP_010334.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:538788-540686:+ | gene-YDR049W_ThermosaccDry | rna-NM_001180357.1_ThermosaccDry | cds-NP_010334.1_ThermosaccDry | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:551492-553390:+ | gene-YDR049W_VR1 | rna-NM_001180357.1_VR1 | cds-NP_010334.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:536396-538294:+ | gene-YDR049W_ZTW1 | rna-NM_001180357.1_ZTW1 | cds-NP_010334.1_ZTW1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:540787-542687:+ | gene-YDR049W_Sparadoxus | rna-NM_001180357.1_Sparadoxus | cds-NP_010334.1_Sparadoxus | 87.8 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |