Gene name: VAM6
Reference locus (S288C): YDL077C
Gene biotype: protein_coding
Description: Vacuolar morphogenesis protein 6; Guanine nucleotide exchange factor for the GTPase Gtr1p; subunit of the HOPS endocytic tethering complex; vacuole membrane protein; functions as a Rab GTPase effector, interacting with both GTP- and GDP-bound conformations of Ypt7p; facilitates tethering and promotes membrane fusion events at the late endosome and vacuole; required for both membrane and protein trafficking; component of vacuole-mitochondrion contacts (vCLAMPs) important for lipid transfer between organelles
Top 10 interactors (score): VPS3 (0.999); YPT7 (0.999); VAM3 (0.999); PEP3 (0.999); NYV1 (0.999); VPS16 (0.999); PEP5 (0.999); VPS8 (0.999); VPS41 (0.999); VAM7 (0.999); VPS33 (0.999); VPS21 (0.999); YPT6 (0.999); VTI1 (0.99); MON1 (0.99); YPT52 (0.984); YKT6 (0.982); GTR1 (0.971); YPT32 (0.954); VMA6 (0.94)
Homologues (species, bitscore): VPS39 (Homo sapiens, 131.7); Vps39 (Mus musculus, 129.8); vps39 (Danio rerio, 136.0); vps39 (Xenopus tropicalis, 117.1); Vps39 (Drosophila melanogaster, 122.9); vps-39 (Caenorhabditis elegans, 77.0); EMB2754 (Arabidopsis thaliana, 55.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:301569-304718:- | gene-YDL077C_AKU4011 | rna-NM_001180136.1_AKU4011 | cds-NP_010206.1_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:245209-248358:+ | gene-YDL077C_BG1 | rna-NM_001180136.1_BG1 | cds-NP_010206.1_BG1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:319253-322402:- | gene-YDL077C_Bruggeman | rna-NM_001180136.1_Bruggeman | cds-NP_010206.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:315745-318894:- | gene-YDL077C_CAT1 | rna-NM_001180136.1_CAT1 | cds-NP_010206.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:299841-302990:- | gene-YDL077C_CBS1585 | rna-NM_001180136.1_CBS1585 | cds-NP_010206.1_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:316522-319671:- | gene-YDL077C_CBS436 | rna-NM_001180136.1_CBS436 | cds-NP_010206.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:298268-301417:- | gene-YDL077C_CBS6412 | rna-NM_001180136.1_CBS6412 | cds-NP_010206.1_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:317894-321043:- | gene-YDL077C_CBS6413 | rna-NM_001180136.1_CBS6413 | cds-NP_010206.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:315794-318943:- | gene-YDL077C_CENPK1137D | rna-NM_001180136.1_CENPK1137D | cds-NP_010206.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:312607-315756:- | gene-YDL077C_EthanolRed | rna-NM_001180136.1_EthanolRed | cds-NP_010206.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:318579-321728:- | gene-YDL077C_FaliES1 | rna-NM_001180136.1_FaliES1 | cds-NP_010206.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000010.1:88648-91797:- | gene-YDL077C_JAY291 | rna-NM_001180136.1_JAY291 | cds-NP_010206.1_JAY291 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:316770-319919:- | gene-YDL077C_MUCL30387 | rna-NM_001180136.1_MUCL30387 | cds-NP_010206.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:307796-310945:- | gene-YDL077C_MUCL30388 | rna-NM_001180136.1_MUCL30388 | cds-NP_010206.1_MUCL30388 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:300946-304095:- | gene-YDL077C_MUCL39482 | rna-NM_001180136.1_MUCL39482 | cds-NP_010206.1_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:222956-226105:- | gene-YDL077C_MUCL42920 | rna-NM_001180136.1_MUCL42920 | cds-NP_010206.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:316894-320043:- | gene-YDL077C_NCIM3186 | rna-NM_001180136.1_NCIM3186 | cds-NP_010206.1_NCIM3186 | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:300960-304109:- | gene-YDL077C_NCYC1407 | rna-NM_001180136.1_NCYC1407 | cds-NP_010206.1_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:307766-310915:- | gene-YDL077C_PE2H3 | rna-NM_001180136.1_PE2H3 | cds-NP_010206.1_PE2H3 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:307744-310893:- | gene-YDL077C_PE2H4 | rna-NM_001180136.1_PE2H4 | cds-NP_010206.1_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:316971-320120:- | gene-YDL077C_S288C | rna-NM_001180136.1_S288C | cds-NP_010206.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000010.1:114801-117950:+ | gene-YDL077C_SA1 | rna-NM_001180136.1_SA1 | cds-NP_010206.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:318090-321239:- | gene-YDL077C_ThermosaccDry | rna-NM_001180136.1_ThermosaccDry | cds-NP_010206.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:320163-323312:- | gene-YDL077C_VR1 | rna-NM_001180136.1_VR1 | cds-NP_010206.1_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:316005-319154:- | gene-YDL077C_ZTW1 | rna-NM_001180136.1_ZTW1 | cds-NP_010206.1_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:318133-321282:- | gene-YDL077C_Sparadoxus | rna-NM_001180136.1_Sparadoxus | cds-NP_010206.1_Sparadoxus | 90.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |