Gene name: VAC14
Reference locus (S288C): YLR386W
Gene biotype: protein_coding
Description: Vacuole morphology and inheritance protein 14; Enzyme regulator; involved in synthesis of phosphatidylinositol 3,5-bisphosphate, in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; binds negative (Fig4p) and positive (Fab1p) regulators of PtdIns(3,5)P(2) to control endolysosome function; similar to mammalian Vac14p
Top 10 interactors (score): FAB1 (0.999); FIG4 (0.999); ATG18 (0.998); VAC7 (0.997); SEC4 (0.977); VPS34 (0.969); VPS30 (0.942); VPS15 (0.916); ATG14 (0.9); VPS38 (0.9); ATG38 (0.9); VAC8 (0.766); VPH1 (0.716); YNL324W (0.707); YKL050C (0.7); PIK1 (0.68); SEA4 (0.667); RTC1 (0.649); SEH1 (0.647); SET2 (0.641)
Homologues (species, bitscore): VAC14 (Homo sapiens, 363.6); Vac14 (Mus musculus, 369.0); vac14 (Danio rerio, 370.9); vac14 (Xenopus tropicalis, 361.3); CG5608 (Drosophila melanogaster, 295.0); K04G2.6 (Caenorhabditis elegans, 240.0); AT2G01690 (Arabidopsis thaliana, 355.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:843165-845807:+ | gene-YLR386W_AKU4011 | rna-NM_001182275.3_AKU4011 | cds-NP_013490.3_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000048.1:75344-77986:+ | gene-YLR386W_BG1 | rna-NM_001182275.3_BG1 | cds-NP_013490.3_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:881471-884113:+ | gene-YLR386W_Bruggeman | rna-NM_001182275.3_Bruggeman | cds-NP_013490.3_Bruggeman | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:876997-879639:+ | gene-YLR386W_CAT1 | rna-NM_001182275.3_CAT1 | cds-NP_013490.3_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:878761-881403:+ | gene-YLR386W_CBS1585 | rna-NM_001182275.3_CBS1585 | cds-NP_013490.3_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:862402-865044:+ | gene-YLR386W_CBS436 | rna-NM_001182275.3_CBS436 | cds-NP_013490.3_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:914802-917444:+ | gene-YLR386W_CBS6412 | rna-NM_001182275.3_CBS6412 | cds-NP_013490.3_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:879052-881694:+ | gene-YLR386W_CBS6413 | rna-NM_001182275.3_CBS6413 | cds-NP_013490.3_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:878442-881084:+ | gene-YLR386W_CENPK1137D | rna-NM_001182275.3_CENPK1137D | cds-NP_013490.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:835708-838350:+ | gene-YLR386W_EthanolRed | rna-NM_001182275.3_EthanolRed | cds-NP_013490.3_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:865018-867660:+ | gene-YLR386W_FaliES1 | rna-NM_001182275.3_FaliES1 | cds-NP_013490.3_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000434.1:18176-20818:+ | gene-YLR386W_JAY291 | rna-NM_001182275.3_JAY291 | cds-NP_013490.3_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:880336-882978:+ | gene-YLR386W_MUCL30387 | rna-NM_001182275.3_MUCL30387 | cds-NP_013490.3_MUCL30387 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:886422-889064:+ | gene-YLR386W_MUCL30388 | rna-NM_001182275.3_MUCL30388 | cds-NP_013490.3_MUCL30388 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:879981-882623:+ | gene-YLR386W_MUCL39482 | rna-NM_001182275.3_MUCL39482 | cds-NP_013490.3_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:874638-877280:+ | gene-YLR386W_MUCL42920 | rna-NM_001182275.3_MUCL42920 | cds-NP_013490.3_MUCL42920 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:893602-896244:+ | gene-YLR386W_NCIM3186 | rna-NM_001182275.3_NCIM3186 | cds-NP_013490.3_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:889161-891803:+ | gene-YLR386W_NCYC1407 | rna-NM_001182275.3_NCYC1407 | cds-NP_013490.3_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:875555-878197:+ | gene-YLR386W_PE2H3 | rna-NM_001182275.3_PE2H3 | cds-NP_013490.3_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:875299-877941:+ | gene-YLR386W_PE2H4 | rna-NM_001182275.3_PE2H4 | cds-NP_013490.3_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:893628-896270:+ | gene-YLR386W_S288C | rna-NM_001182275.3_S288C | cds-NP_013490.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000007.1:152417-155059:- | gene-YLR386W_SA1 | rna-NM_001182275.3_SA1 | cds-NP_013490.3_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:868097-870739:+ | gene-YLR386W_ThermosaccDry | rna-NM_001182275.3_ThermosaccDry | cds-NP_013490.3_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:880645-883287:+ | gene-YLR386W_VR1 | rna-NM_001182275.3_VR1 | cds-NP_013490.3_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000025.1:204813-207455:+ | gene-YLR386W_ZTW1 | rna-NM_001182275.3_ZTW1 | cds-NP_013490.3_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:853516-856158:+ | gene-YLR386W_Sparadoxus | rna-NM_001182275.3_Sparadoxus | cds-NP_013490.3_Sparadoxus | 91.0 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |