URA8 (YJR103W)


Gene profile

Gene name: URA8
Reference locus (S288C): YJR103W
Gene biotype: protein_coding

Description: Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication

Top 10 interactors (score): URA7 (0.999); GUA1 (0.978); YNK1 (0.962); IMD2 (0.941); IMD3 (0.937); URA2 (0.935); ADE12 (0.931); RPA135 (0.925); RPA190 (0.916); YND1 (0.908); URA1 (0.874); ASN2 (0.865); LIA1 (0.857); SGT2 (0.851); ADE4 (0.832); IMD4 (0.832); URA10 (0.83); ASN1 (0.829); IMD1 (0.825); GCD7 (0.814)

Homologues (species, bitscore): CTPS1 (Homo sapiens, 664.5); Ctps (Mus musculus, 667.2); ctps1b (Danio rerio, 679.1); ctps1 (Xenopus tropicalis, 659.1); CTPsyn (Drosophila melanogaster, 637.1); ctps-1 (Caenorhabditis elegans, 565.1); emb2742 (Arabidopsis thaliana, 643.3)

External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser


Comparative analysis of strains

Search table

strain assembly application macro_region gene_coord geneID rnaID protID %id %cov_exon status copyNumber copyID nORFs match_ref_CDS validORF missing_startCodon missing_stopCodon outOfFrame_stopCodon
AKU4011 GCA_001738255.1 Sake Asia CM005304.1:592258-593994:+ gene-YJR103W_AKU4011 rna-NM_001181761.4_AKU4011 cds-NP_012637.4_AKU4011 99.8 100.0 Verified 1 1 1 True True False False False
BG1 GCA_001932575.1 Bioethanol South America MSHP01000190.1:13600-15336:- gene-YJR103W_BG1 rna-NM_001181761.4_BG1 cds-NP_012637.4_BG1 99.5 100.0 Verified 1 1 1 False True False False False
Bruggeman GCA_001738585.1 Bread Not Applicable CM005512.1:607987-609722:+ gene-YJR103W_Bruggeman rna-NM_001181761.4_Bruggeman cds-NP_012637.4_Bruggeman 99.7 99.9 Unannotated 1 1 0 False False False True False
CAT1 GCA_001738705.1 Bioethanol South America CM005528.1:611466-613202:+ gene-YJR103W_CAT1 rna-NM_001181761.4_CAT1 cds-NP_012637.4_CAT1 99.5 100.0 Verified 1 1 1 False True False False False
CBS1585 GCA_001738375.1 Sake Asia CM005368.1:604314-606050:+ gene-YJR103W_CBS1585 rna-NM_001181761.4_CBS1585 cds-NP_012637.4_CBS1585 99.7 100.0 Verified 1 1 1 False True False False False
CBS436 GCA_001738355.1 Sake Asia CM005352.1:622905-624641:+ gene-YJR103W_CBS436 rna-NM_001181761.4_CBS436 cds-NP_012637.4_CBS436 99.5 100.0 Mismatch 1 1 1 False True False False False
CBS6412 GCA_001738345.1 Sake Asia CM005336.1:591461-593197:+ gene-YJR103W_CBS6412 rna-NM_001181761.4_CBS6412 cds-NP_012637.4_CBS6412 99.9 100.0 Mismatch 1 1 1 True True False False False
CBS6413 GCA_001738265.1 Sake Asia CM005320.1:593722-595458:+ gene-YJR103W_CBS6413 rna-NM_001181761.4_CBS6413 cds-NP_012637.4_CBS6413 99.9 100.0 Verified 1 1 1 True True False False False
CENPK1137D GCA_000269885.1 Laboratory Not Applicable CM001531.1:603072-604808:+ gene-YJR103W_CENPK1137D rna-NM_001181761.4_CENPK1137D cds-NP_012637.4_CENPK1137D 100.0 100.0 Verified 1 1 1 True True False False False
EthanolRed GCA_001738615.1 Bioethanol Asia CM005480.1:596676-598412:+ gene-YJR103W_EthanolRed rna-NM_001181761.4_EthanolRed cds-NP_012637.4_EthanolRed 99.8 100.0 Verified 1 1 1 True True False False False
FaliES1 GCA_001738715.1 Bioethanol Asia CM005544.1:608142-609878:+ gene-YJR103W_FaliES1 rna-NM_001181761.4_FaliES1 cds-NP_012637.4_FaliES1 99.8 100.0 Verified 1 1 1 True True False False False
JAY291 GCA_000182315.2 Bioethanol South America ACFL01000054.1:79543-81279:- gene-YJR103W_JAY291 rna-NM_001181761.4_JAY291 cds-NP_012637.4_JAY291 99.7 100.0 Verified 1 1 1 True True False False False
MUCL30387 GCA_001738515.1 Bread Europe CM005416.1:606536-608271:+ gene-YJR103W_MUCL30387 rna-NM_001181761.4_MUCL30387 cds-NP_012637.4_MUCL30387 99.7 99.9 Unannotated 1 1 0 False False False True False
MUCL30388 GCA_001738495.1 Bread Europe CM005448.1:604505-606241:+ gene-YJR103W_MUCL30388 rna-NM_001181761.4_MUCL30388 cds-NP_012637.4_MUCL30388 99.8 100.0 Verified 1 1 1 True True False False False
MUCL39482 GCA_001738235.1 Sake Asia CM005288.1:597782-599518:+ gene-YJR103W_MUCL39482 rna-NM_001181761.4_MUCL39482 cds-NP_012637.4_MUCL39482 99.8 100.0 Verified 1 1 1 True True False False False
MUCL42920 GCA_001738485.1 Bread Europe CM005432.1:602033-603769:+ gene-YJR103W_MUCL42920 rna-NM_001181761.4_MUCL42920 cds-NP_012637.4_MUCL42920 99.7 100.0 Verified 1 1 1 False True False False False
NCIM3186 GCA_001029075.1 Bioethanol Asia CP011819.1:620733-622469:+ gene-YJR103W_NCIM3186 rna-NM_001181761.4_NCIM3186 cds-NP_012637.4_NCIM3186 99.5 100.0 Verified 1 1 1 False True False False False
NCYC1407 GCA_001738225.1 Sake Asia CM005272.1:595340-597076:+ gene-YJR103W_NCYC1407 rna-NM_001181761.4_NCYC1407 cds-NP_012637.4_NCYC1407 99.8 100.0 Verified 1 1 1 False True False False False
PE2H3 GCA_905220325.1 Bioethanol South America HG994149.1:613237-614973:+ gene-YJR103W_PE2H3 rna-NM_001181761.4_PE2H3 cds-NP_012637.4_PE2H3 99.7 100.0 Verified 1 1 1 True True False False False
PE2H4 GCA_905220315.1 Bioethanol South America LR999881.1:606926-608662:+ gene-YJR103W_PE2H4 rna-NM_001181761.4_PE2H4 cds-NP_012637.4_PE2H4 99.7 100.0 Verified 1 1 1 True True False False False
S288C GCF_000146045.2 Laboratory Not applicable NC_001142.9:620754-622490:+ gene-YJR103W_S288C rna-NM_001181761.4_S288C cds-NP_012637.4_S288C 100.0 100.0 Verified 1 1 1 True True False False False
SA1 GCA_004114265.1 Bioethanol South America SDIA01000038.1:79311-81047:+ gene-YJR103W_SA1 rna-NM_001181761.4_SA1 cds-NP_012637.4_SA1 99.7 100.0 Verified 1 1 1 True True False False False
ThermosaccDry GCA_001738605.1 Bioethanol Asia CM005496.1:602076-603812:+ gene-YJR103W_ThermosaccDry rna-NM_001181761.4_ThermosaccDry cds-NP_012637.4_ThermosaccDry 99.8 100.0 Verified 1 1 1 True True False False False
VR1 GCA_001738595.1 Bioethanol South America CM005464.1:604181-605917:+ gene-YJR103W_VR1 rna-NM_001181761.4_VR1 cds-NP_012637.4_VR1 99.5 100.0 Verified 1 1 1 False True False False False
ZTW1 GCA_000308935.1 Bioethanol Asia AMDD01000021.1:581441-583177:+ gene-YJR103W_ZTW1 rna-NM_001181761.4_ZTW1 cds-NP_012637.4_ZTW1 99.8 100.0 Verified 1 1 1 True True False False False
Sparadoxus GCF_002079055.1 Not applicable Not applicable NC_047496.1:615257-616993:+ gene-YJR103W_Sparadoxus rna-NM_001181761.4_Sparadoxus cds-NP_012637.4_Sparadoxus 91.7 100.0 Verified 1 1 1 False True False False False

Additional files