Gene name: URA2
Reference locus (S288C): YJL130C
Gene biotype: protein_coding
Description: Protein URA2; Bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase; catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP; In the central section; belongs to the metallo- dependent hydrolases superfamily. DHOase family. CAD subfamily
Top 10 interactors (score): URA4 (0.997); ADE4 (0.994); URA1 (0.993); ADE12 (0.992); URA5 (0.988); AAT2 (0.987); ARG1 (0.983); YMR084W (0.978); ADE6 (0.975); GLN1 (0.97); URA3 (0.97); ASN2 (0.968); GFA1 (0.962); GUA1 (0.962); ASN1 (0.958); CPA2 (0.952); CPA1 (0.951); AAT1 (0.949); GLT1 (0.941); URA8 (0.935)
Homologues (species, bitscore): CAD (Homo sapiens, 2186.0); Cad (Mus musculus, 2192.9); cad (Danio rerio, 2190.6); cad (Xenopus tropicalis, 1738.0); r (Drosophila melanogaster, 2110.9); pyr-1 (Caenorhabditis elegans, 1989.9); CARB (Arabidopsis thaliana, 790.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005304.1:154018-160662:- | gene-YJL130C_AKU4011 | rna-NM_001181563.2_AKU4011 | cds-NP_012405.2_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000190.1:453056-459700:+ | gene-YJL130C_BG1 | rna-NM_001181563.2_BG1 | cds-NP_012405.2_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005512.1:166102-172746:- | gene-YJL130C_Bruggeman | rna-NM_001181563.2_Bruggeman | cds-NP_012405.2_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005528.1:169891-176535:- | gene-YJL130C_CAT1 | rna-NM_001181563.2_CAT1 | cds-NP_012405.2_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005368.1:159652-166296:- | gene-YJL130C_CBS1585 | rna-NM_001181563.2_CBS1585 | cds-NP_012405.2_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005352.1:184401-191045:- | gene-YJL130C_CBS436 | rna-NM_001181563.2_CBS436 | cds-NP_012405.2_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005336.1:155671-162315:- | gene-YJL130C_CBS6412 | rna-NM_001181563.2_CBS6412 | cds-NP_012405.2_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005320.1:157127-163771:- | gene-YJL130C_CBS6413 | rna-NM_001181563.2_CBS6413 | cds-NP_012405.2_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001531.1:148194-154838:- | gene-YJL130C_CENPK1137D | rna-NM_001181563.2_CENPK1137D | cds-NP_012405.2_CENPK1137D | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005480.1:158002-164646:- | gene-YJL130C_EthanolRed | rna-NM_001181563.2_EthanolRed | cds-NP_012405.2_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005544.1:163653-170297:- | gene-YJL130C_FaliES1 | rna-NM_001181563.2_FaliES1 | cds-NP_012405.2_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000099.1:44832-51476:- | gene-YJL130C_JAY291 | rna-NM_001181563.2_JAY291 | cds-NP_012405.2_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005416.1:168371-175015:- | gene-YJL130C_MUCL30387 | rna-NM_001181563.2_MUCL30387 | cds-NP_012405.2_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005448.1:164422-171066:- | gene-YJL130C_MUCL30388 | rna-NM_001181563.2_MUCL30388 | cds-NP_012405.2_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005288.1:158600-165244:- | gene-YJL130C_MUCL39482 | rna-NM_001181563.2_MUCL39482 | cds-NP_012405.2_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005432.1:164164-170808:- | gene-YJL130C_MUCL42920 | rna-NM_001181563.2_MUCL42920 | cds-NP_012405.2_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011819.1:165702-172346:- | gene-YJL130C_NCIM3186 | rna-NM_001181563.2_NCIM3186 | cds-NP_012405.2_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005272.1:157007-163651:- | gene-YJL130C_NCYC1407 | rna-NM_001181563.2_NCYC1407 | cds-NP_012405.2_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994149.1:169810-176454:- | gene-YJL130C_PE2H3 | rna-NM_001181563.2_PE2H3 | cds-NP_012405.2_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999881.1:169454-176098:- | gene-YJL130C_PE2H4 | rna-NM_001181563.2_PE2H4 | cds-NP_012405.2_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001142.9:165723-172367:- | gene-YJL130C_S288C | rna-NM_001181563.2_S288C | cds-NP_012405.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000085.1:26803-33447:+ | gene-YJL130C_SA1 | rna-NM_001181563.2_SA1 | cds-NP_012405.2_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005496.1:156844-163488:- | gene-YJL130C_ThermosaccDry | rna-NM_001181563.2_ThermosaccDry | cds-NP_012405.2_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005464.1:163927-170571:- | gene-YJL130C_VR1 | rna-NM_001181563.2_VR1 | cds-NP_012405.2_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000021.1:144136-150780:- | gene-YJL130C_ZTW1 | rna-NM_001181563.2_ZTW1 | cds-NP_012405.2_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047496.1:169364-176008:- | gene-YJL130C_Sparadoxus | rna-NM_001181563.2_Sparadoxus | cds-NP_012405.2_Sparadoxus | 92.9 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |