Gene name: UPC2
Reference locus (S288C): YDR213W
Gene biotype: protein_coding
Description: Sterol uptake control protein 2; Sterol regulatory element binding protein; induces sterol biosynthetic genes, upon sterol depletion; acts as a sterol sensor, binding ergosterol in sterol rich conditions; relocates from intracellular membranes to perinuclear foci upon sterol depletion; redundant activator of filamentation with ECM22, up-regulating the expression of filamentous growth genes; contains a Zn[2]-Cys[6] binuclear cluster; UPC2 has a paralog, ECM22, that arose from the whole genome duplication
Top 10 interactors (score): ERG11 (0.967); ERG2 (0.96); ERG3 (0.926); MOT3 (0.861); ROX1 (0.855); ERG20 (0.844); AUS1 (0.843); ERG6 (0.833); ERG9 (0.819); ELO3 (0.811); DAN1 (0.8); ERG5 (0.798); ECM22 (0.79); ERG24 (0.755); PDR11 (0.746); ERG7 (0.731); ERG1 (0.729); ERG25 (0.723); ERG10 (0.723); BTS1 (0.717)
Homologues (species, bitscore): setd2 (Danio rerio, 68.6); CG6118 (Drosophila melanogaster, 65.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:846396-849137:+ | gene-YDR213W_AKU4011 | rna-NM_001180521.1_AKU4011 | cds-NP_010499.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000080.1:276616-279357:- | gene-YDR213W_BG1 | rna-NM_001180521.1_BG1 | cds-NP_010499.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:878801-881542:+ | gene-YDR213W_Bruggeman | rna-NM_001180521.1_Bruggeman | cds-NP_010499.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:866067-868808:+ | gene-YDR213W_CAT1 | rna-NM_001180521.1_CAT1 | cds-NP_010499.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:836749-839490:+ | gene-YDR213W_CBS1585 | rna-NM_001180521.1_CBS1585 | cds-NP_010499.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:865816-868557:+ | gene-YDR213W_CBS436 | rna-NM_001180521.1_CBS436 | cds-NP_010499.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:833561-836302:+ | gene-YDR213W_CBS6412 | rna-NM_001180521.1_CBS6412 | cds-NP_010499.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:864106-866847:+ | gene-YDR213W_CBS6413 | rna-NM_001180521.1_CBS6413 | cds-NP_010499.1_CBS6413 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:888550-891291:+ | gene-YDR213W_CENPK1137D | rna-NM_001180521.1_CENPK1137D | cds-NP_010499.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:847136-849877:+ | gene-YDR213W_EthanolRed | rna-NM_001180521.1_EthanolRed | cds-NP_010499.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:855342-858083:+ | gene-YDR213W_FaliES1 | rna-NM_001180521.1_FaliES1 | cds-NP_010499.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000058.1:5273-8014:+ | gene-YDR213W_JAY291 | rna-NM_001180521.1_JAY291 | cds-NP_010499.1_JAY291 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:864452-867193:+ | gene-YDR213W_MUCL30387 | rna-NM_001180521.1_MUCL30387 | cds-NP_010499.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:852706-855447:+ | gene-YDR213W_MUCL30388 | rna-NM_001180521.1_MUCL30388 | cds-NP_010499.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:838201-840942:+ | gene-YDR213W_MUCL39482 | rna-NM_001180521.1_MUCL39482 | cds-NP_010499.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:777501-780242:+ | gene-YDR213W_MUCL42920 | rna-NM_001180521.1_MUCL42920 | cds-NP_010499.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:889674-892415:+ | gene-YDR213W_NCIM3186 | rna-NM_001180521.1_NCIM3186 | cds-NP_010499.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:841887-844628:+ | gene-YDR213W_NCYC1407 | rna-NM_001180521.1_NCYC1407 | cds-NP_010499.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:858083-860824:+ | gene-YDR213W_PE2H3 | rna-NM_001180521.1_PE2H3 | cds-NP_010499.1_PE2H3 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:863364-866105:+ | gene-YDR213W_PE2H4 | rna-NM_001180521.1_PE2H4 | cds-NP_010499.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:889751-892492:+ | gene-YDR213W_S288C | rna-NM_001180521.1_S288C | cds-NP_010499.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000013.1:95849-98590:+ | gene-YDR213W_SA1 | rna-NM_001180521.1_SA1 | cds-NP_010499.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:853503-856244:+ | gene-YDR213W_ThermosaccDry | rna-NM_001180521.1_ThermosaccDry | cds-NP_010499.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:868729-871470:+ | gene-YDR213W_VR1 | rna-NM_001180521.1_VR1 | cds-NP_010499.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000007.1:116220-118961:+ | gene-YDR213W_ZTW1 | rna-NM_001180521.1_ZTW1 | cds-NP_010499.1_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:858638-861388:+ | gene-YDR213W_Sparadoxus | rna-NM_001180521.1_Sparadoxus | cds-NP_010499.1_Sparadoxus | 90.1 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |