Gene name: UFD1
Reference locus (S288C): YGR048W
Gene biotype: protein_coding
Description: Ubiquitin fusion degradation protein 1; Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase; polyubiquitin binding protein that assists in the dislocation of misfolded, ERAD substrates that are subsequently delivered to the proteasome for degradation; involved in regulated destruction of ER membrane proteins such as HMG-CoA reductase (Hmg1/2p) and cytoplasmic proteins (Fbp1p); involved in mobilizing membrane bound transcription factors by regulated Ub/proteasome-dependent processing (RUP)
Top 10 interactors (score): CDC48 (0.999); DER1 (0.999); UBX2 (0.999); NPL4 (0.999); HRD1 (0.998); SSM4 (0.997); DOA1 (0.996); HRD3 (0.995); UFD2 (0.994); RQC1 (0.99); UBC7 (0.988); RQC2 (0.988); CUE1 (0.985); RKR1 (0.983); USA1 (0.98); RPN10 (0.977); UBX5 (0.966); OTU1 (0.957); RPT5 (0.945); SHP1 (0.944)
Homologues (species, bitscore): UFD1L (Homo sapiens, 207.2); Ufd1l (Mus musculus, 207.2); ufd1l (Danio rerio, 203.4); ufd1l (Xenopus tropicalis, 205.7); Ufd1-like (Drosophila melanogaster, 202.2); ufd-1 (Caenorhabditis elegans, 168.3); AT4G38930 (Arabidopsis thaliana, 195.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:573526-574611:+ | gene-YGR048W_AKU4011 | rna-NM_001181177.1_AKU4011 | cds-NP_011562.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000060.1:1221-2306:- | gene-YGR048W_BG1 | rna-NM_001181177.1_BG1 | cds-NP_011562.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:575818-576903:+ | gene-YGR048W_Bruggeman | rna-NM_001181177.1_Bruggeman | cds-NP_011562.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:574224-575309:+ | gene-YGR048W_CAT1 | rna-NM_001181177.1_CAT1 | cds-NP_011562.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:574839-575924:+ | gene-YGR048W_CBS1585 | rna-NM_001181177.1_CBS1585 | cds-NP_011562.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:576134-577219:+ | gene-YGR048W_CBS436 | rna-NM_001181177.1_CBS436 | cds-NP_011562.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:567635-568720:+ | gene-YGR048W_CBS6412 | rna-NM_001181177.1_CBS6412 | cds-NP_011562.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:571635-572720:+ | gene-YGR048W_CBS6413 | rna-NM_001181177.1_CBS6413 | cds-NP_011562.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:589545-590630:+ | gene-YGR048W_CENPK1137D | rna-NM_001181177.1_CENPK1137D | cds-NP_011562.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:561767-562852:+ | gene-YGR048W_EthanolRed | rna-NM_001181177.1_EthanolRed | cds-NP_011562.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:565251-566336:+ | gene-YGR048W_FaliES1 | rna-NM_001181177.1_FaliES1 | cds-NP_011562.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000435.1:16222-17307:+ | gene-YGR048W_JAY291 | rna-NM_001181177.1_JAY291 | cds-NP_011562.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:572451-573536:+ | gene-YGR048W_MUCL30387 | rna-NM_001181177.1_MUCL30387 | cds-NP_011562.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:575847-576932:+ | gene-YGR048W_MUCL30388 | rna-NM_001181177.1_MUCL30388 | cds-NP_011562.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:570657-571742:+ | gene-YGR048W_MUCL39482 | rna-NM_001181177.1_MUCL39482 | cds-NP_011562.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:580469-581554:+ | gene-YGR048W_MUCL42920 | rna-NM_001181177.1_MUCL42920 | cds-NP_011562.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:589826-590911:+ | gene-YGR048W_NCIM3186 | rna-NM_001181177.1_NCIM3186 | cds-NP_011562.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:564852-565937:+ | gene-YGR048W_NCYC1407 | rna-NM_001181177.1_NCYC1407 | cds-NP_011562.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:568123-569208:+ | gene-YGR048W_PE2H3 | rna-NM_001181177.1_PE2H3 | cds-NP_011562.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:573230-574315:+ | gene-YGR048W_PE2H4 | rna-NM_001181177.1_PE2H4 | cds-NP_011562.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:589826-590911:+ | gene-YGR048W_S288C | rna-NM_001181177.1_S288C | cds-NP_011562.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000015.1:16279-17364:+ | gene-YGR048W_SA1 | rna-NM_001181177.1_SA1 | cds-NP_011562.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:584588-585673:+ | gene-YGR048W_ThermosaccDry | rna-NM_001181177.1_ThermosaccDry | cds-NP_011562.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:681501-682586:+ | gene-YGR048W_VR1 | rna-NM_001181177.1_VR1 | cds-NP_011562.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000015.1:40066-41151:+ | gene-YGR048W_ZTW1 | rna-NM_001181177.1_ZTW1 | cds-NP_011562.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:575036-576121:+ | gene-YGR048W_Sparadoxus | rna-NM_001181177.1_Sparadoxus | cds-NP_011562.1_Sparadoxus | 90.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |