Gene name: UBR1
Reference locus (S288C): YGR184C
Gene biotype: protein_coding
Description: E3 ubiquitin ligase (N-recognin); heterodimerizes with Rad6p to recognize and ubiquitinate substrates of the N-end rule pathway; role in endoplasmic reticulum-associated protein degradation (ERAD) in the absence of canonical ER membrane ligases or after stress; major role in targeting misfolded cytosolic proteins for degradation; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS)
Top 10 interactors (score): RAD6 (0.999); UFD4 (0.997); CUP9 (0.991); SSM4 (0.988); SAN1 (0.985); HUL5 (0.972); RKR1 (0.962); ATE1 (0.955); UFD2 (0.932); TOM1 (0.903); UBC4 (0.901); BRE1 (0.899); HRD1 (0.882); RSP5 (0.873); RAD18 (0.87); SSE1 (0.861); SOK1 (0.85); UFD1 (0.849); CDC48 (0.834); PTR2 (0.83)
Homologues (species, bitscore): UBR2 (Homo sapiens, 174.9); Ubr2 (Mus musculus, 180.3); ubr2 (Danio rerio, 166.0); ubr2 (Xenopus tropicalis, 177.2); CG9086 (Drosophila melanogaster, 158.3); ubr-1 (Caenorhabditis elegans, 124.4); PRT6 (Arabidopsis thaliana, 74.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:827655-833507:- | gene-YGR184C_AKU4011 | rna-NM_001181313.1_AKU4011 | cds-NP_011700.1_AKU4011 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000021.1:105762-111614:- | gene-YGR184C_BG1 | rna-NM_001181313.1_BG1 | cds-NP_011700.1_BG1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:833582-839434:- | gene-YGR184C_Bruggeman | rna-NM_001181313.1_Bruggeman | cds-NP_011700.1_Bruggeman | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:829681-835533:- | gene-YGR184C_CAT1 | rna-NM_001181313.1_CAT1 | cds-NP_011700.1_CAT1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:828371-834223:- | gene-YGR184C_CBS1585 | rna-NM_001181313.1_CBS1585 | cds-NP_011700.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:832259-838111:- | gene-YGR184C_CBS436 | rna-NM_001181313.1_CBS436 | cds-NP_011700.1_CBS436 | 99.0 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:819741-825593:- | gene-YGR184C_CBS6412 | rna-NM_001181313.1_CBS6412 | cds-NP_011700.1_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:825237-831089:- | gene-YGR184C_CBS6413 | rna-NM_001181313.1_CBS6413 | cds-NP_011700.1_CBS6413 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:859626-865478:- | gene-YGR184C_CENPK1137D | rna-NM_001181313.1_CENPK1137D | cds-NP_011700.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:814245-820097:- | gene-YGR184C_EthanolRed | rna-NM_001181313.1_EthanolRed | cds-NP_011700.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:818636-824488:- | gene-YGR184C_FaliES1 | rna-NM_001181313.1_FaliES1 | cds-NP_011700.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000364.1:10299-16151:+ | gene-YGR184C_JAY291 | rna-NM_001181313.1_JAY291 | cds-NP_011700.1_JAY291 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:831072-836924:- | gene-YGR184C_MUCL30387 | rna-NM_001181313.1_MUCL30387 | cds-NP_011700.1_MUCL30387 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:830783-836635:- | gene-YGR184C_MUCL30388 | rna-NM_001181313.1_MUCL30388 | cds-NP_011700.1_MUCL30388 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:823945-829796:- | gene-YGR184C_MUCL39482 | rna-NM_001181313.1_MUCL39482 | cds-NP_011700.1_MUCL39482 | 99.5 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:840562-846414:- | gene-YGR184C_MUCL42920 | rna-NM_001181313.1_MUCL42920 | cds-NP_011700.1_MUCL42920 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:859901-865753:- | gene-YGR184C_NCIM3186 | rna-NM_001181313.1_NCIM3186 | cds-NP_011700.1_NCIM3186 | 98.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:819054-824906:- | gene-YGR184C_NCYC1407 | rna-NM_001181313.1_NCYC1407 | cds-NP_011700.1_NCYC1407 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:838246-844098:- | gene-YGR184C_PE2H3 | rna-NM_001181313.1_PE2H3 | cds-NP_011700.1_PE2H3 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:843356-849208:- | gene-YGR184C_PE2H4 | rna-NM_001181313.1_PE2H4 | cds-NP_011700.1_PE2H4 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:859901-865753:- | gene-YGR184C_S288C | rna-NM_001181313.1_S288C | cds-NP_011700.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000035.1:83618-89470:- | gene-YGR184C_SA1 | rna-NM_001181313.1_SA1 | cds-NP_011700.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:839147-844999:- | gene-YGR184C_ThermosaccDry | rna-NM_001181313.1_ThermosaccDry | cds-NP_011700.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:943391-949243:- | gene-YGR184C_VR1 | rna-NM_001181313.1_VR1 | cds-NP_011700.1_VR1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000016.1:140582-146434:- | gene-YGR184C_ZTW1 | rna-NM_001181313.1_ZTW1 | cds-NP_011700.1_ZTW1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:830759-836614:- | gene-YGR184C_Sparadoxus | rna-NM_001181313.1_Sparadoxus | cds-NP_011700.1_Sparadoxus | 90.6 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |