Gene name: UBP6
Reference locus (S288C): YFR010W
Gene biotype: protein_coding
Description: Ubiquitin-specific protease; situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains en bloc, rather than from the distal tip of the chain; negatively regulates degradation of ubiquitinated proteins by the proteasome; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance; human homolog UBP14 complements yeast null mutant
Top 10 interactors (score): PRE9 (0.999); PRE6 (0.999); SCL1 (0.999); UBI4 (0.999); RPN1 (0.999); PRE10 (0.999); PRE5 (0.999); RPT2 (0.999); RPT1 (0.999); RPN6 (0.999); RPN2 (0.999); PUP3 (0.999); PRE1 (0.999); PRE7 (0.999); RPT3 (0.999); RPT4 (0.999); RPT6 (0.999); RPN13 (0.999); PRE8 (0.999); RPN3 (0.999)
Homologues (species, bitscore): USP14 (Homo sapiens, 242.7); Usp14 (Mus musculus, 243.4); usp14 (Danio rerio, 243.4); usp14 (Xenopus tropicalis, 233.4); Usp14 (Drosophila melanogaster, 215.3); usp-14 (Caenorhabditis elegans, 203.0); UBP7 (Arabidopsis thaliana, 241.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005300.1:155511-157010:+ | gene-YFR010W_AKU4011 | rna-NM_001179975.1_AKU4011 | cds-NP_116665.1_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000071.1:103829-105328:- | gene-YFR010W_BG1 | rna-NM_001179975.1_BG1 | cds-NP_116665.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005508.1:155931-157430:+ | gene-YFR010W_Bruggeman | rna-NM_001179975.1_Bruggeman | cds-NP_116665.1_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005524.1:160595-162094:+ | gene-YFR010W_CAT1 | rna-NM_001179975.1_CAT1 | cds-NP_116665.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005364.1:156335-157834:+ | gene-YFR010W_CBS1585 | rna-NM_001179975.1_CBS1585 | cds-NP_116665.1_CBS1585 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005348.1:130190-131689:+ | gene-YFR010W_CBS436 | rna-NM_001179975.1_CBS436 | cds-NP_116665.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005332.1:156075-157574:+ | gene-YFR010W_CBS6412 | rna-NM_001179975.1_CBS6412 | cds-NP_116665.1_CBS6412 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005316.1:158588-160087:+ | gene-YFR010W_CBS6413 | rna-NM_001179975.1_CBS6413 | cds-NP_116665.1_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001527.1:161199-162698:+ | gene-YFR010W_CENPK1137D | rna-NM_001179975.1_CENPK1137D | cds-NP_116665.1_CENPK1137D | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005476.1:154500-155999:+ | gene-YFR010W_EthanolRed | rna-NM_001179975.1_EthanolRed | cds-NP_116665.1_EthanolRed | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005540.1:156147-157646:+ | gene-YFR010W_FaliES1 | rna-NM_001179975.1_FaliES1 | cds-NP_116665.1_FaliES1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000452.1:2992-4491:+ | gene-YFR010W_JAY291 | rna-NM_001179975.1_JAY291 | cds-NP_116665.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005412.1:157883-159382:+ | gene-YFR010W_MUCL30387 | rna-NM_001179975.1_MUCL30387 | cds-NP_116665.1_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005444.1:154690-156189:+ | gene-YFR010W_MUCL30388 | rna-NM_001179975.1_MUCL30388 | cds-NP_116665.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005284.1:154778-156277:+ | gene-YFR010W_MUCL39482 | rna-NM_001179975.1_MUCL39482 | cds-NP_116665.1_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005428.1:154046-155545:+ | gene-YFR010W_MUCL42920 | rna-NM_001179975.1_MUCL42920 | cds-NP_116665.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011815.1:165066-166565:+ | gene-YFR010W_NCIM3186 | rna-NM_001179975.1_NCIM3186 | cds-NP_116665.1_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005268.1:155796-157295:+ | gene-YFR010W_NCYC1407 | rna-NM_001179975.1_NCYC1407 | cds-NP_116665.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994145.1:174870-176369:+ | gene-YFR010W_PE2H3 | rna-NM_001179975.1_PE2H3 | cds-NP_116665.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999877.1:174418-175917:+ | gene-YFR010W_PE2H4 | rna-NM_001179975.1_PE2H4 | cds-NP_116665.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001138.5:165067-166566:+ | gene-YFR010W_S288C | rna-NM_001179975.1_S288C | cds-NP_116665.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000011.1:157647-159146:- | gene-YFR010W_SA1 | rna-NM_001179975.1_SA1 | cds-NP_116665.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005492.1:155305-156804:+ | gene-YFR010W_ThermosaccDry | rna-NM_001179975.1_ThermosaccDry | cds-NP_116665.1_ThermosaccDry | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005460.1:170768-172267:+ | gene-YFR010W_VR1 | rna-NM_001179975.1_VR1 | cds-NP_116665.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000013.1:85754-87253:+ | gene-YFR010W_ZTW1 | rna-NM_001179975.1_ZTW1 | cds-NP_116665.1_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047492.1:179638-181137:+ | gene-YFR010W_Sparadoxus | rna-NM_001179975.1_Sparadoxus | cds-NP_116665.1_Sparadoxus | 93.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |