Gene name: UBP3
Reference locus (S288C): YER151C
Gene biotype: protein_coding
Description: Ubiquitin carboxyl-terminal hydrolase 3; Ubiquitin-specific protease involved in transport and osmotic response; negatively regulates Ras/PKA signaling; interacts with Bre5p to coregulate anterograde, retrograde transport between ER and Golgi; involved in transcription elongation in response to osmostress through phosphorylation at Ser695 by Hog1p; inhibitor of gene silencing; role in ribophagy; cleaves ubiquitin fusions but not polyubiquitin; protein abundance increases in response to DNA replication stress
Top 10 interactors (score): BRE5 (0.999); UBP2 (0.97); BLM10 (0.97); RPN11 (0.923); SIR4 (0.921); RPO21 (0.92); UBP14 (0.919); UBP15 (0.916); RSP5 (0.914); OTU2 (0.897); ATG19 (0.882); DOA4 (0.874); UFD4 (0.868); UBP12 (0.859); DOA1 (0.841); CDC48 (0.833); YUH1 (0.831); OTU1 (0.814); UBP1 (0.764); DST1 (0.762)
Homologues (species, bitscore): USP10 (Homo sapiens, 168.3); Usp10 (Mus musculus, 166.4); usp10 (Danio rerio, 169.1); usp10 (Xenopus tropicalis, 166.0); Usp10 (Drosophila melanogaster, 125.6); usp-3 (Caenorhabditis elegans, 68.9); UBP24 (Arabidopsis thaliana, 136.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:457190-459928:- | gene-YER151C_AKU4011 | rna-NM_001179041.3_AKU4011 | cds-NP_011078.3_AKU4011 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000176.1:73113-75851:+ | gene-YER151C_BG1 | rna-NM_001179041.3_BG1 | cds-NP_011078.3_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:468471-471209:- | gene-YER151C_Bruggeman | rna-NM_001179041.3_Bruggeman | cds-NP_011078.3_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:456312-459050:- | gene-YER151C_CAT1 | rna-NM_001179041.3_CAT1 | cds-NP_011078.3_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:457001-459739:- | gene-YER151C_CBS1585 | rna-NM_001179041.3_CBS1585 | cds-NP_011078.3_CBS1585 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:460815-463553:- | gene-YER151C_CBS436 | rna-NM_001179041.3_CBS436 | cds-NP_011078.3_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:455519-458257:- | gene-YER151C_CBS6412 | rna-NM_001179041.3_CBS6412 | cds-NP_011078.3_CBS6412 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:463555-466293:- | gene-YER151C_CBS6413 | rna-NM_001179041.3_CBS6413 | cds-NP_011078.3_CBS6413 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:467459-470197:- | gene-YER151C_CENPK1137D | rna-NM_001179041.3_CENPK1137D | cds-NP_011078.3_CENPK1137D | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:463472-466210:- | gene-YER151C_EthanolRed | rna-NM_001179041.3_EthanolRed | cds-NP_011078.3_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:464058-466796:- | gene-YER151C_FaliES1 | rna-NM_001179041.3_FaliES1 | cds-NP_011078.3_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000111.1:19696-22434:+ | gene-YER151C_JAY291 | rna-NM_001179041.3_JAY291 | cds-NP_011078.3_JAY291 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:457221-459959:- | gene-YER151C_MUCL30387 | rna-NM_001179041.3_MUCL30387 | cds-NP_011078.3_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:460120-462858:- | gene-YER151C_MUCL30388 | rna-NM_001179041.3_MUCL30388 | cds-NP_011078.3_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:452958-455696:- | gene-YER151C_MUCL39482 | rna-NM_001179041.3_MUCL39482 | cds-NP_011078.3_MUCL39482 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:465288-468026:- | gene-YER151C_MUCL42920 | rna-NM_001179041.3_MUCL42920 | cds-NP_011078.3_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:469685-472423:- | gene-YER151C_NCIM3186 | rna-NM_001179041.3_NCIM3186 | cds-NP_011078.3_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 0 | False | False | True | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:462424-465162:- | gene-YER151C_NCYC1407 | rna-NM_001179041.3_NCYC1407 | cds-NP_011078.3_NCYC1407 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:478105-480843:- | gene-YER151C_PE2H3 | rna-NM_001179041.3_PE2H3 | cds-NP_011078.3_PE2H3 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:468046-470784:- | gene-YER151C_PE2H4 | rna-NM_001179041.3_PE2H4 | cds-NP_011078.3_PE2H4 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:469686-472424:- | gene-YER151C_S288C | rna-NM_001179041.3_S288C | cds-NP_011078.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000030.1:27586-30324:- | gene-YER151C_SA1 | rna-NM_001179041.3_SA1 | cds-NP_011078.3_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:464858-467596:- | gene-YER151C_ThermosaccDry | rna-NM_001179041.3_ThermosaccDry | cds-NP_011078.3_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:457969-460707:- | gene-YER151C_VR1 | rna-NM_001179041.3_VR1 | cds-NP_011078.3_VR1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000010.1:19820-22558:- | gene-YER151C_ZTW1 | rna-NM_001179041.3_ZTW1 | cds-NP_011078.3_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:465868-468609:- | gene-YER151C_Sparadoxus | rna-NM_001179041.3_Sparadoxus | cds-NP_011078.3_Sparadoxus | 88.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |