Gene name: UBC4
Reference locus (S288C): YBR082C
Gene biotype: protein_coding
Description: Ubiquitin-conjugating enzyme (E2); key E2 partner with Ubc1p for the anaphase-promoting complex (APC); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; regulates levels of DNA Polymerase-{alpha} to promote efficient and accurate DNA replication; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication
Top 10 interactors (score): MOT2 (0.999); UBA1 (0.999); APC11 (0.999); UBC1 (0.997); RSP5 (0.995); UBI4 (0.986); MMS2 (0.986); UFD4 (0.983); UBC5 (0.982); HRT1 (0.978); UBC9 (0.968); PEX10 (0.958); SLX5 (0.956); SLX8 (0.951); PEX12 (0.935); UFD2 (0.92); SMT3 (0.907); CDC53 (0.906); UBR1 (0.901); PEX5 (0.89)
Homologues (species, bitscore): UBE2D4 (Homo sapiens, 257.7); Ube2d3 (Mus musculus, 255.4); ube2d1b (Danio rerio, 257.3); ube2d3 (Xenopus tropicalis, 255.4); eff (Drosophila melanogaster, 255.4); let-70 (Caenorhabditis elegans, 253.8); UBC30 (Arabidopsis thaliana, 258.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005296.1:389003-389544:- | gene-YBR082C_AKU4011 | rna-NM_001178430.1_AKU4011 | cds-NP_009638.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000179.1:379990-380531:- | gene-YBR082C_BG1 | rna-NM_001178430.1_BG1 | cds-NP_009638.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005504.1:390579-391120:- | gene-YBR082C_Bruggeman | rna-NM_001178430.1_Bruggeman | cds-NP_009638.1_Bruggeman | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005520.1:393556-394097:- | gene-YBR082C_CAT1 | rna-NM_001178430.1_CAT1 | cds-NP_009638.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005360.1:381288-381829:- | gene-YBR082C_CBS1585 | rna-NM_001178430.1_CBS1585 | cds-NP_009638.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005344.1:389395-389936:- | gene-YBR082C_CBS436 | rna-NM_001178430.1_CBS436 | cds-NP_009638.1_CBS436 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:479518-480059:- | gene-YBR082C_CBS6412 | rna-NM_001178430.1_CBS6412 | cds-NP_009638.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005312.1:386428-386969:- | gene-YBR082C_CBS6413 | rna-NM_001178430.1_CBS6413 | cds-NP_009638.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001523.1:400386-400927:- | gene-YBR082C_CENPK1137D | rna-NM_001178430.1_CENPK1137D | cds-NP_009638.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005472.1:515795-516336:- | gene-YBR082C_EthanolRed | rna-NM_001178430.1_EthanolRed | cds-NP_009638.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005536.1:405078-405619:- | gene-YBR082C_FaliES1 | rna-NM_001178430.1_FaliES1 | cds-NP_009638.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000013.1:21582-22123:+ | gene-YBR082C_JAY291 | rna-NM_001178430.1_JAY291 | cds-NP_009638.1_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005408.1:391641-392183:- | gene-YBR082C_MUCL30387 | rna-NM_001178430.1_MUCL30387 | cds-NP_009638.1_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005440.1:391809-392350:- | gene-YBR082C_MUCL30388 | rna-NM_001178430.1_MUCL30388 | cds-NP_009638.1_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005280.1:381279-381820:- | gene-YBR082C_MUCL39482 | rna-NM_001178430.1_MUCL39482 | cds-NP_009638.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005424.1:388491-389033:- | gene-YBR082C_MUCL42920 | rna-NM_001178430.1_MUCL42920 | cds-NP_009638.1_MUCL42920 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011811.1:406425-406966:- | gene-YBR082C_NCIM3186 | rna-NM_001178430.1_NCIM3186 | cds-NP_009638.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005264.1:382211-382752:- | gene-YBR082C_NCYC1407 | rna-NM_001178430.1_NCYC1407 | cds-NP_009638.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994141.1:394790-395331:- | gene-YBR082C_PE2H3 | rna-NM_001178430.1_PE2H3 | cds-NP_009638.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999873.1:392466-393007:- | gene-YBR082C_PE2H4 | rna-NM_001178430.1_PE2H4 | cds-NP_009638.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001134.8:406628-407169:- | gene-YBR082C_S288C | rna-NM_001178430.1_S288C | cds-NP_009638.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000017.1:70351-70892:+ | gene-YBR082C_SA1 | rna-NM_001178430.1_SA1 | cds-NP_009638.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005488.1:404085-404626:- | gene-YBR082C_ThermosaccDry | rna-NM_001178430.1_ThermosaccDry | cds-NP_009638.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005456.1:386070-386611:- | gene-YBR082C_VR1 | rna-NM_001178430.1_VR1 | cds-NP_009638.1_VR1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000003.1:379753-380294:- | gene-YBR082C_ZTW1 | rna-NM_001178430.1_ZTW1 | cds-NP_009638.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047488.1:416682-417235:- | gene-YBR082C_Sparadoxus | rna-NM_001178430.1_Sparadoxus | cds-NP_009638.1_Sparadoxus | 95.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |