Gene name: TYW1
Reference locus (S288C): YPL207W
Gene biotype: protein_coding
Description: S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase; Iron-sulfer protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron; Belongs to the TYW1 family
Top 10 interactors (score): TRM12 (0.999); TRM5 (0.998); TYW3 (0.996); PPM2 (0.995); ERB1 (0.948); DRS1 (0.929); PUF6 (0.91); RET1 (0.908); PWP2 (0.895); CCC1 (0.882); NMD3 (0.875); PWP1 (0.854); NOP7 (0.829); YAP5 (0.81); BMS1 (0.809); TRM112 (0.801); PNO1 (0.796); GRX4 (0.782); RPA135 (0.757); NBP35 (0.739)
Homologues (species, bitscore): TYW1 (Homo sapiens, 472.2); Tyw1 (Mus musculus, 475.7); tyw1 (Danio rerio, 463.4); tyw1 (Xenopus tropicalis, 465.7); AT1G75200 (Arabidopsis thaliana, 450.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:137785-140217:+ | gene-YPL207W_AKU4011 | rna-NM_001184021.1_AKU4011 | cds-NP_015117.1_AKU4011 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000069.1:343551-345983:+ | gene-YPL207W_BG1 | rna-NM_001184021.1_BG1 | cds-NP_015117.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:163245-165677:+ | gene-YPL207W_Bruggeman | rna-NM_001184021.1_Bruggeman | cds-NP_015117.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:159853-162285:+ | gene-YPL207W_CAT1 | rna-NM_001184021.1_CAT1 | cds-NP_015117.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:141970-144402:+ | gene-YPL207W_CBS1585 | rna-NM_001184021.1_CBS1585 | cds-NP_015117.1_CBS1585 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:156389-158821:+ | gene-YPL207W_CBS436 | rna-NM_001184021.1_CBS436 | cds-NP_015117.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:146774-149206:+ | gene-YPL207W_CBS6412 | rna-NM_001184021.1_CBS6412 | cds-NP_015117.1_CBS6412 | 99.0 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:138148-140580:+ | gene-YPL207W_CBS6413 | rna-NM_001184021.1_CBS6413 | cds-NP_015117.1_CBS6413 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:159846-162288:+ | gene-YPL207W_CENPK1137D | rna-NM_001184021.1_CENPK1137D | cds-NP_015117.1_CENPK1137D | 99.2 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:136901-139333:+ | gene-YPL207W_EthanolRed | rna-NM_001184021.1_EthanolRed | cds-NP_015117.1_EthanolRed | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:144107-146539:+ | gene-YPL207W_FaliES1 | rna-NM_001184021.1_FaliES1 | cds-NP_015117.1_FaliES1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000069.1:11790-14222:- | gene-YPL207W_JAY291 | rna-NM_001184021.1_JAY291 | cds-NP_015117.1_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:154957-157389:+ | gene-YPL207W_MUCL30387 | rna-NM_001184021.1_MUCL30387 | cds-NP_015117.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:153148-155580:+ | gene-YPL207W_MUCL30388 | rna-NM_001184021.1_MUCL30388 | cds-NP_015117.1_MUCL30388 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:135100-137532:+ | gene-YPL207W_MUCL39482 | rna-NM_001184021.1_MUCL39482 | cds-NP_015117.1_MUCL39482 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:153979-156411:+ | gene-YPL207W_MUCL42920 | rna-NM_001184021.1_MUCL42920 | cds-NP_015117.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:159892-162324:+ | gene-YPL207W_NCIM3186 | rna-NM_001184021.1_NCIM3186 | cds-NP_015117.1_NCIM3186 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:141549-143981:+ | gene-YPL207W_NCYC1407 | rna-NM_001184021.1_NCYC1407 | cds-NP_015117.1_NCYC1407 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:149252-151684:+ | gene-YPL207W_PE2H3 | rna-NM_001184021.1_PE2H3 | cds-NP_015117.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:148895-151327:+ | gene-YPL207W_PE2H4 | rna-NM_001184021.1_PE2H4 | cds-NP_015117.1_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:159909-162341:+ | gene-YPL207W_S288C | rna-NM_001184021.1_S288C | cds-NP_015117.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000095.1:11841-14273:- | gene-YPL207W_SA1 | rna-NM_001184021.1_SA1 | cds-NP_015117.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:143888-146320:+ | gene-YPL207W_ThermosaccDry | rna-NM_001184021.1_ThermosaccDry | cds-NP_015117.1_ThermosaccDry | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:157931-160304:+ | gene-YPL207W_VR1 | rna-NM_001184021.1_VR1 | cds-NP_015117.1_VR1 | 94.5 | 96.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:143408-145840:+ | gene-YPL207W_ZTW1 | rna-NM_001184021.1_ZTW1 | cds-NP_015117.1_ZTW1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:144961-147402:+ | gene-YPL207W_Sparadoxus | rna-NM_001184021.1_Sparadoxus | cds-NP_015117.1_Sparadoxus | 89.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |