Gene name: TYS1
Reference locus (S288C): YGR185C
Gene biotype: protein_coding
Description: Tyrosine--tRNA ligase, cytoplasmic; Cytoplasmic tyrosyl-tRNA synthetase; required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies; human ortholog YARS functionally complements the heat sensitivity of a ts allele; protein abundance increases in response to DNA replication stress; Belongs to the class-I aminoacyl-tRNA synthetase family
Top 10 interactors (score): ALA1 (0.995); GUS1 (0.995); CDC60 (0.994); KRS1 (0.993); SES1 (0.992); WRS1 (0.992); NAM2 (0.992); GLN4 (0.989); MSY1 (0.989); THS1 (0.988); MES1 (0.986); YNL247W (0.984); HTS1 (0.982); ILS1 (0.979); GRS1 (0.976); FRS2 (0.975); YDR341C (0.974); ARC1 (0.966); MSK1 (0.959); MSM1 (0.948)
Homologues (species, bitscore): YARS (Homo sapiens, 409.8); Yars (Mus musculus, 411.0); yars (Danio rerio, 426.4); yars (Xenopus tropicalis, 419.5); Aats-tyr (Drosophila melanogaster, 407.1); yrs-2 (Caenorhabditis elegans, 320.5); AT2G33840 (Arabidopsis thaliana, 136.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:834089-835273:- | gene-YGR185C_AKU4011 | rna-NM_001181314.3_AKU4011 | cds-NP_011701.3_AKU4011 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000021.1:112197-113381:- | gene-YGR185C_BG1 | rna-NM_001181314.3_BG1 | cds-NP_011701.3_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:840017-841201:- | gene-YGR185C_Bruggeman | rna-NM_001181314.3_Bruggeman | cds-NP_011701.3_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:836116-837300:- | gene-YGR185C_CAT1 | rna-NM_001181314.3_CAT1 | cds-NP_011701.3_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:834805-835989:- | gene-YGR185C_CBS1585 | rna-NM_001181314.3_CBS1585 | cds-NP_011701.3_CBS1585 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:838694-839878:- | gene-YGR185C_CBS436 | rna-NM_001181314.3_CBS436 | cds-NP_011701.3_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:826175-827359:- | gene-YGR185C_CBS6412 | rna-NM_001181314.3_CBS6412 | cds-NP_011701.3_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:831671-832855:- | gene-YGR185C_CBS6413 | rna-NM_001181314.3_CBS6413 | cds-NP_011701.3_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:866061-867245:- | gene-YGR185C_CENPK1137D | rna-NM_001181314.3_CENPK1137D | cds-NP_011701.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:820680-821864:- | gene-YGR185C_EthanolRed | rna-NM_001181314.3_EthanolRed | cds-NP_011701.3_EthanolRed | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:825071-826255:- | gene-YGR185C_FaliES1 | rna-NM_001181314.3_FaliES1 | cds-NP_011701.3_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000364.1:8532-9716:+ | gene-YGR185C_JAY291 | rna-NM_001181314.3_JAY291 | cds-NP_011701.3_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:837507-838691:- | gene-YGR185C_MUCL30387 | rna-NM_001181314.3_MUCL30387 | cds-NP_011701.3_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:837218-838402:- | gene-YGR185C_MUCL30388 | rna-NM_001181314.3_MUCL30388 | cds-NP_011701.3_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:830378-831562:- | gene-YGR185C_MUCL39482 | rna-NM_001181314.3_MUCL39482 | cds-NP_011701.3_MUCL39482 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:846997-848181:- | gene-YGR185C_MUCL42920 | rna-NM_001181314.3_MUCL42920 | cds-NP_011701.3_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:866336-867520:- | gene-YGR185C_NCIM3186 | rna-NM_001181314.3_NCIM3186 | cds-NP_011701.3_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:825488-826672:- | gene-YGR185C_NCYC1407 | rna-NM_001181314.3_NCYC1407 | cds-NP_011701.3_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:844681-845865:- | gene-YGR185C_PE2H3 | rna-NM_001181314.3_PE2H3 | cds-NP_011701.3_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:849791-850975:- | gene-YGR185C_PE2H4 | rna-NM_001181314.3_PE2H4 | cds-NP_011701.3_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:866336-867520:- | gene-YGR185C_S288C | rna-NM_001181314.3_S288C | cds-NP_011701.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000035.1:90052-91236:- | gene-YGR185C_SA1 | rna-NM_001181314.3_SA1 | cds-NP_011701.3_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:845582-846766:- | gene-YGR185C_ThermosaccDry | rna-NM_001181314.3_ThermosaccDry | cds-NP_011701.3_ThermosaccDry | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:949826-951010:- | gene-YGR185C_VR1 | rna-NM_001181314.3_VR1 | cds-NP_011701.3_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000016.1:147017-148201:- | gene-YGR185C_ZTW1 | rna-NM_001181314.3_ZTW1 | cds-NP_011701.3_ZTW1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:837191-838375:- | gene-YGR185C_Sparadoxus | rna-NM_001181314.3_Sparadoxus | cds-NP_011701.3_Sparadoxus | 92.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |