Gene name: TUP1
Reference locus (S288C): YCR084C
Gene biotype: protein_coding
Description: General transcriptional corepressor TUP1; General repressor of transcription; forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes
Top 10 interactors (score): CYC8 (0.999); SKO1 (0.998); NRG1 (0.996); MIG1 (0.99); HOG1 (0.928); ROX1 (0.926); SET1 (0.891); HMLALPHA2 (0.884); RFX1 (0.878); DUN1 (0.87); SFL1 (0.865); RPD3 (0.863); SNF1 (0.854); MOT3 (0.852); NRG2 (0.847); RIM101 (0.837); RGT1 (0.831); PHD1 (0.828); UME6 (0.826); CYR1 (0.824)
Homologues (species, bitscore): WDR5 (Homo sapiens, 129.4); Wdr5 (Mus musculus, 129.4); wdr5 (Danio rerio, 129.0); wdr5 (Xenopus tropicalis, 127.1); wds (Drosophila melanogaster, 129.4); wdr-5.2 (Caenorhabditis elegans, 122.1); WDR5a (Arabidopsis thaliana, 144.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005297.1:254814-256955:- | gene-YCR084C_AKU4011 | rna-NM_001178790.1_AKU4011 | cds-NP_010007.1_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000067.1:113566-115707:- | gene-YCR084C_BG1 | rna-NM_001178790.1_BG1 | cds-NP_010007.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005505.1:251019-253160:- | gene-YCR084C_Bruggeman | rna-NM_001178790.1_Bruggeman | cds-NP_010007.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005521.1:262071-264212:- | gene-YCR084C_CAT1 | rna-NM_001178790.1_CAT1 | cds-NP_010007.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005361.1:249629-251770:- | gene-YCR084C_CBS1585 | rna-NM_001178790.1_CBS1585 | cds-NP_010007.1_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005345.1:261404-263545:- | gene-YCR084C_CBS436 | rna-NM_001178790.1_CBS436 | cds-NP_010007.1_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005329.1:241001-243122:- | gene-YCR084C_CBS6412 | rna-NM_001178790.1_CBS6412 | cds-NP_010007.1_CBS6412 | 98.3 | 99.0 | Mismatch | 1 | 1 | 0 | False | False | False | True | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005313.1:255679-257820:- | gene-YCR084C_CBS6413 | rna-NM_001178790.1_CBS6413 | cds-NP_010007.1_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001524.1:259679-261835:- | gene-YCR084C_CENPK1137D | rna-NM_001178790.1_CENPK1137D | cds-NP_010007.1_CENPK1137D | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005473.1:250629-252770:- | gene-YCR084C_EthanolRed | rna-NM_001178790.1_EthanolRed | cds-NP_010007.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005537.1:255992-258133:- | gene-YCR084C_FaliES1 | rna-NM_001178790.1_FaliES1 | cds-NP_010007.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000323.1:30660-32801:+ | gene-YCR084C_JAY291 | rna-NM_001178790.1_JAY291 | cds-NP_010007.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005409.1:248147-250288:- | gene-YCR084C_MUCL30387 | rna-NM_001178790.1_MUCL30387 | cds-NP_010007.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005441.1:248014-250155:- | gene-YCR084C_MUCL30388 | rna-NM_001178790.1_MUCL30388 | cds-NP_010007.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005281.1:256193-258334:- | gene-YCR084C_MUCL39482 | rna-NM_001178790.1_MUCL39482 | cds-NP_010007.1_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005425.1:252596-254737:- | gene-YCR084C_MUCL42920 | rna-NM_001178790.1_MUCL42920 | cds-NP_010007.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011812.1:259943-262084:- | gene-YCR084C_NCIM3186 | rna-NM_001178790.1_NCIM3186 | cds-NP_010007.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005265.1:257032-259173:- | gene-YCR084C_NCYC1407 | rna-NM_001178790.1_NCYC1407 | cds-NP_010007.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994142.1:271584-273725:- | gene-YCR084C_PE2H3 | rna-NM_001178790.1_PE2H3 | cds-NP_010007.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999874.1:260136-262277:- | gene-YCR084C_PE2H4 | rna-NM_001178790.1_PE2H4 | cds-NP_010007.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001135.5:260311-262452:- | gene-YCR084C_S288C | rna-NM_001178790.1_S288C | cds-NP_010007.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000044.1:60156-62297:- | gene-YCR084C_SA1 | rna-NM_001178790.1_SA1 | cds-NP_010007.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005489.1:255919-258060:- | gene-YCR084C_ThermosaccDry | rna-NM_001178790.1_ThermosaccDry | cds-NP_010007.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005457.1:267125-269266:- | gene-YCR084C_VR1 | rna-NM_001178790.1_VR1 | cds-NP_010007.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000004.1:253772-255913:- | gene-YCR084C_ZTW1 | rna-NM_001178790.1_ZTW1 | cds-NP_010007.1_ZTW1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047489.1:287918-290059:- | gene-YCR084C_Sparadoxus | rna-NM_001178790.1_Sparadoxus | cds-NP_010007.1_Sparadoxus | 92.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |