Gene name: TUF1
Reference locus (S288C): YOR187W
Gene biotype: protein_coding
Description: Mitochondrial translation elongation factor Tu (EF-Tu); involved in fundamental pathway of mtDNA homeostasis; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans; rare mutations in human mitochondrial elongation factor Tu (EFTu) associated with severe lactic acidosis, rapidly progressive fatal encephalopathy, severe infantile macrocystic leukodystrophy with micropolygyria
Top 10 interactors (score): RML2 (0.992); MRPL8 (0.991); ATG5 (0.99); RPS3 (0.988); ATP1 (0.986); MRPS5 (0.981); MRP7 (0.976); MRPS9 (0.973); MNP1 (0.97); MRPL7 (0.967); MEF1 (0.963); MRPS16 (0.962); ATP2 (0.962); RPL5 (0.959); YML6 (0.955); RPS2 (0.953); MEF2 (0.953); MRPL1 (0.949); ATP3 (0.949); PDB1 (0.949)
Homologues (species, bitscore): TUFM (Homo sapiens, 516.9); Tufm (Mus musculus, 511.9); tufm (Danio rerio, 526.9); TUFM (Xenopus tropicalis, 203.0); EfTuM (Drosophila melanogaster, 508.4); tufm-1 (Caenorhabditis elegans, 432.6); AT4G02930 (Arabidopsis thaliana, 552.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:681357-682670:+ | gene-YOR187W_AKU4011 | rna-NM_001183606.1_AKU4011 | cds-NP_014830.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000123.1:83408-84721:+ | gene-YOR187W_BG1 | rna-NM_001183606.1_BG1 | cds-NP_014830.1_BG1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:665364-666677:+ | gene-YOR187W_Bruggeman | rna-NM_001183606.1_Bruggeman | cds-NP_014830.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:666538-667851:+ | gene-YOR187W_CAT1 | rna-NM_001183606.1_CAT1 | cds-NP_014830.1_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:664346-665659:+ | gene-YOR187W_CBS1585 | rna-NM_001183606.1_CBS1585 | cds-NP_014830.1_CBS1585 | 99.6 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:662458-663771:+ | gene-YOR187W_CBS436 | rna-NM_001183606.1_CBS436 | cds-NP_014830.1_CBS436 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:661462-662775:+ | gene-YOR187W_CBS6412 | rna-NM_001183606.1_CBS6412 | cds-NP_014830.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:670103-671416:+ | gene-YOR187W_CBS6413 | rna-NM_001183606.1_CBS6413 | cds-NP_014830.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:683780-685093:+ | gene-YOR187W_CENPK1137D | rna-NM_001183606.1_CENPK1137D | cds-NP_014830.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:657326-658639:+ | gene-YOR187W_EthanolRed | rna-NM_001183606.1_EthanolRed | cds-NP_014830.1_EthanolRed | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:662399-663712:+ | gene-YOR187W_FaliES1 | rna-NM_001183606.1_FaliES1 | cds-NP_014830.1_FaliES1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000038.1:13823-15136:- | gene-YOR187W_JAY291 | rna-NM_001183606.1_JAY291 | cds-NP_014830.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:670168-671481:+ | gene-YOR187W_MUCL30387 | rna-NM_001183606.1_MUCL30387 | cds-NP_014830.1_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:677583-678896:+ | gene-YOR187W_MUCL30388 | rna-NM_001183606.1_MUCL30388 | cds-NP_014830.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:671676-672989:+ | gene-YOR187W_MUCL39482 | rna-NM_001183606.1_MUCL39482 | cds-NP_014830.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:681056-682369:+ | gene-YOR187W_MUCL42920 | rna-NM_001183606.1_MUCL42920 | cds-NP_014830.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:683919-685232:+ | gene-YOR187W_NCIM3186 | rna-NM_001183606.1_NCIM3186 | cds-NP_014830.1_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:671773-673086:+ | gene-YOR187W_NCYC1407 | rna-NM_001183606.1_NCYC1407 | cds-NP_014830.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:670595-671908:+ | gene-YOR187W_PE2H3 | rna-NM_001183606.1_PE2H3 | cds-NP_014830.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:680972-682285:+ | gene-YOR187W_PE2H4 | rna-NM_001183606.1_PE2H4 | cds-NP_014830.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:684030-685343:+ | gene-YOR187W_S288C | rna-NM_001183606.1_S288C | cds-NP_014830.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000006.1:100588-101901:+ | gene-YOR187W_SA1 | rna-NM_001183606.1_SA1 | cds-NP_014830.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:661583-662896:+ | gene-YOR187W_ThermosaccDry | rna-NM_001183606.1_ThermosaccDry | cds-NP_014830.1_ThermosaccDry | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:725621-726934:+ | gene-YOR187W_VR1 | rna-NM_001183606.1_VR1 | cds-NP_014830.1_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000032.1:394985-396298:+ | gene-YOR187W_ZTW1 | rna-NM_001183606.1_ZTW1 | cds-NP_014830.1_ZTW1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:667186-668499:+ | gene-YOR187W_Sparadoxus | rna-NM_001183606.1_Sparadoxus | cds-NP_014830.1_Sparadoxus | 92.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |