Gene name: TSL1
Reference locus (S288C): YML100W
Gene biotype: protein_coding
Description: Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; contributes to survival to acute lethal heat stress; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication
Top 10 interactors (score): TPS1 (0.999); TPS3 (0.999); TPS2 (0.999); NTH1 (0.994); GSY2 (0.992); GAD1 (0.986); UGP1 (0.983); GSY1 (0.978); GLC3 (0.977); PGM2 (0.976); DCS2 (0.975); SOL4 (0.975); MSC1 (0.974); NTH2 (0.969); GLK1 (0.959); ATH1 (0.953); HSP42 (0.949); RTC3 (0.948); YHL012W (0.943); CTT1 (0.939)
Homologues (species, bitscore): Tps1 (Drosophila melanogaster, 189.1); tps-2 (Caenorhabditis elegans, 142.5); TPS2 (Arabidopsis thaliana, 303.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:64345-67641:+ | gene-YML100W_AKU4011 | rna-NM_001182460.1_AKU4011 | cds-NP_013608.1_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000201.1:408486-411782:- | gene-YML100W_BG1 | rna-NM_001182460.1_BG1 | cds-NP_013608.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005515.1:70600-73896:+ | gene-YML100W_Bruggeman | rna-NM_001182460.1_Bruggeman | cds-NP_013608.1_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005531.1:72159-75455:+ | gene-YML100W_CAT1 | rna-NM_001182460.1_CAT1 | cds-NP_013608.1_CAT1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005371.1:64347-67643:+ | gene-YML100W_CBS1585 | rna-NM_001182460.1_CBS1585 | cds-NP_013608.1_CBS1585 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005355.1:70339-73635:+ | gene-YML100W_CBS436 | rna-NM_001182460.1_CBS436 | cds-NP_013608.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:65110-68406:+ | gene-YML100W_CBS6412 | rna-NM_001182460.1_CBS6412 | cds-NP_013608.1_CBS6412 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005323.1:63574-66870:+ | gene-YML100W_CBS6413 | rna-NM_001182460.1_CBS6413 | cds-NP_013608.1_CBS6413 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001534.1:65217-68510:+ | gene-YML100W_CENPK1137D | rna-NM_001182460.1_CENPK1137D | cds-NP_013608.1_CENPK1137D | 99.6 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005483.1:64851-68147:+ | gene-YML100W_EthanolRed | rna-NM_001182460.1_EthanolRed | cds-NP_013608.1_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005547.1:65128-68424:+ | gene-YML100W_FaliES1 | rna-NM_001182460.1_FaliES1 | cds-NP_013608.1_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000345.1:21757-25053:- | gene-YML100W_JAY291 | rna-NM_001182460.1_JAY291 | cds-NP_013608.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005419.1:69045-72341:+ | gene-YML100W_MUCL30387 | rna-NM_001182460.1_MUCL30387 | cds-NP_013608.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005451.1:72270-75566:+ | gene-YML100W_MUCL30388 | rna-NM_001182460.1_MUCL30388 | cds-NP_013608.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005291.1:64361-67657:+ | gene-YML100W_MUCL39482 | rna-NM_001182460.1_MUCL39482 | cds-NP_013608.1_MUCL39482 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005435.1:69159-72455:+ | gene-YML100W_MUCL42920 | rna-NM_001182460.1_MUCL42920 | cds-NP_013608.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011822.1:70578-73874:+ | gene-YML100W_NCIM3186 | rna-NM_001182460.1_NCIM3186 | cds-NP_013608.1_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005275.1:65155-68451:+ | gene-YML100W_NCYC1407 | rna-NM_001182460.1_NCYC1407 | cds-NP_013608.1_NCYC1407 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994152.1:70589-73885:+ | gene-YML100W_PE2H3 | rna-NM_001182460.1_PE2H3 | cds-NP_013608.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999884.1:70527-73823:+ | gene-YML100W_PE2H4 | rna-NM_001182460.1_PE2H4 | cds-NP_013608.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001145.3:70624-73920:+ | gene-YML100W_S288C | rna-NM_001182460.1_S288C | cds-NP_013608.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000054.1:62593-65889:+ | gene-YML100W_SA1 | rna-NM_001182460.1_SA1 | cds-NP_013608.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005499.1:64424-67720:+ | gene-YML100W_ThermosaccDry | rna-NM_001182460.1_ThermosaccDry | cds-NP_013608.1_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:68808-72104:+ | gene-YML100W_VR1 | rna-NM_001182460.1_VR1 | cds-NP_013608.1_VR1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000027.1:43925-47221:+ | gene-YML100W_ZTW1 | rna-NM_001182460.1_ZTW1 | cds-NP_013608.1_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:75318-78614:+ | gene-YML100W_Sparadoxus | rna-NM_001182460.1_Sparadoxus | cds-NP_013608.1_Sparadoxus | 91.0 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |