Gene name: TSC13
Reference locus (S288C): YDL015C
Gene biotype: protein_coding
Description: Trans-2-enoyl-CoA reductase (NADPH) TSC13; Very-long-chain enoyl-CoA reductase; Enoyl reductase; catalyzes last step in each cycle of very long chain fatty acid elongation; localizes to ER, highly enriched in a structure marking nuclear-vacuolar junctions; coimmunoprecipitates with elongases Elo2p and Elo3p; protein increases in abundance and relative distribution to ER foci increases upon DNA replication stress; human homolog TECR implicated in nonsyndromic mental retardation, can complement yeast mutant; Belongs to the steroid 5-alpha reductase family
Top 10 interactors (score): PHS1 (0.999); IFA38 (0.996); ELO3 (0.995); ELO2 (0.993); SEC4 (0.977); ELO1 (0.975); PIM1 (0.963); NVJ1 (0.955); OLE1 (0.947); TES1 (0.915); WBP1 (0.907); DFG10 (0.876); SWH1 (0.822); VAC8 (0.747); SPC3 (0.725); FAS1 (0.713); GCD1 (0.694); AIM2 (0.685); POT1 (0.673); TOM22 (0.662)
Homologues (species, bitscore): TECR (Homo sapiens, 114.8); Tecr (Mus musculus, 120.2); tecra (Danio rerio, 124.4); tecr (Xenopus tropicalis, 115.2); Sc2 (Drosophila melanogaster, 130.6); art-1 (Caenorhabditis elegans, 152.5); CER10 (Arabidopsis thaliana, 127.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:412088-413020:- | gene-YDL015C_AKU4011 | rna-NM_001180074.1_AKU4011 | cds-NP_010269.1_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:136865-137797:+ | gene-YDL015C_BG1 | rna-NM_001180074.1_BG1 | cds-NP_010269.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:432655-433587:- | gene-YDL015C_Bruggeman | rna-NM_001180074.1_Bruggeman | cds-NP_010269.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:425551-426483:- | gene-YDL015C_CAT1 | rna-NM_001180074.1_CAT1 | cds-NP_010269.1_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:408501-409433:- | gene-YDL015C_CBS1585 | rna-NM_001180074.1_CBS1585 | cds-NP_010269.1_CBS1585 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:426027-426959:- | gene-YDL015C_CBS436 | rna-NM_001180074.1_CBS436 | cds-NP_010269.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:406270-407202:- | gene-YDL015C_CBS6412 | rna-NM_001180074.1_CBS6412 | cds-NP_010269.1_CBS6412 | 99.3 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:428267-429199:- | gene-YDL015C_CBS6413 | rna-NM_001180074.1_CBS6413 | cds-NP_010269.1_CBS6413 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:424865-425797:- | gene-YDL015C_CENPK1137D | rna-NM_001180074.1_CENPK1137D | cds-NP_010269.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:420920-421852:- | gene-YDL015C_EthanolRed | rna-NM_001180074.1_EthanolRed | cds-NP_010269.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:427112-428044:- | gene-YDL015C_FaliES1 | rna-NM_001180074.1_FaliES1 | cds-NP_010269.1_FaliES1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000370.1:41596-42528:- | gene-YDL015C_JAY291 | rna-NM_001180074.1_JAY291 | cds-NP_010269.1_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:426545-427477:- | gene-YDL015C_MUCL30387 | rna-NM_001180074.1_MUCL30387 | cds-NP_010269.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:417001-417933:- | gene-YDL015C_MUCL30388 | rna-NM_001180074.1_MUCL30388 | cds-NP_010269.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:410175-411107:- | gene-YDL015C_MUCL39482 | rna-NM_001180074.1_MUCL39482 | cds-NP_010269.1_MUCL39482 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:332053-332985:- | gene-YDL015C_MUCL42920 | rna-NM_001180074.1_MUCL42920 | cds-NP_010269.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:425925-426857:- | gene-YDL015C_NCIM3186 | rna-NM_001180074.1_NCIM3186 | cds-NP_010269.1_NCIM3186 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:409597-410529:- | gene-YDL015C_NCYC1407 | rna-NM_001180074.1_NCYC1407 | cds-NP_010269.1_NCYC1407 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:417078-418010:- | gene-YDL015C_PE2H3 | rna-NM_001180074.1_PE2H3 | cds-NP_010269.1_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:416436-417368:- | gene-YDL015C_PE2H4 | rna-NM_001180074.1_PE2H4 | cds-NP_010269.1_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:426002-426934:- | gene-YDL015C_S288C | rna-NM_001180074.1_S288C | cds-NP_010269.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000010.1:8032-8964:+ | gene-YDL015C_SA1 | rna-NM_001180074.1_SA1 | cds-NP_010269.1_SA1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:426572-427504:- | gene-YDL015C_ThermosaccDry | rna-NM_001180074.1_ThermosaccDry | cds-NP_010269.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:429583-430515:- | gene-YDL015C_VR1 | rna-NM_001180074.1_VR1 | cds-NP_010269.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:424471-425403:- | gene-YDL015C_ZTW1 | rna-NM_001180074.1_ZTW1 | cds-NP_010269.1_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:428613-429545:- | gene-YDL015C_Sparadoxus | rna-NM_001180074.1_Sparadoxus | cds-NP_010269.1_Sparadoxus | 93.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |