Gene name: TSA1
Reference locus (S288C): YML028W
Gene biotype: protein_coding
Description: Peroxiredoxin TSA1; Thioredoxin peroxidase; acts as both ribosome-associated and free cytoplasmic antioxidant; self-associates to form high-molecular weight chaperone complex under oxidative stress; chaperone activity essential for growth in zinc deficiency; required for telomere length maintenance; binds and modulates Cdc19p activity; protein abundance increases, forms cytoplasmic foci during DNA replication stress; TSA1 has a paralog, TSA2, that arose from the whole genome duplication; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily
Top 10 interactors (score): TRR1 (0.996); AHP1 (0.993); SRX1 (0.992); TRX2 (0.992); TRX1 (0.988); YAP1 (0.98); DOT5 (0.974); SOD1 (0.969); SEC4 (0.965); TRR2 (0.964); HYR1 (0.958); CTT1 (0.939); GLR1 (0.924); GPX1 (0.916); SKN7 (0.909); GPX2 (0.908); CTA1 (0.903); TSA2 (0.892); GSH1 (0.89); SOD2 (0.883)
Homologues (species, bitscore): PRDX2 (Homo sapiens, 268.1); Prdx2 (Mus musculus, 269.6); prdx2 (Danio rerio, 256.1); prdx2 (Xenopus tropicalis, 255.8); Jafrac1 (Drosophila melanogaster, 241.1); prdx-2 (Caenorhabditis elegans, 257.3); AT3G11630 (Arabidopsis thaliana, 194.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005307.1:269732-270322:+ | gene-YML028W_AKU4011 | rna-NM_001182386.1_AKU4011 | cds-NP_013684.1_AKU4011 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000201.1:272549-273139:- | gene-YML028W_BG1 | rna-NM_001182386.1_BG1 | cds-NP_013684.1_BG1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005515.1:209686-210276:+ | gene-YML028W_Bruggeman | rna-NM_001182386.1_Bruggeman | cds-NP_013684.1_Bruggeman | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005531.1:212199-212789:+ | gene-YML028W_CAT1 | rna-NM_001182386.1_CAT1 | cds-NP_013684.1_CAT1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005371.1:202681-203271:+ | gene-YML028W_CBS1585 | rna-NM_001182386.1_CBS1585 | cds-NP_013684.1_CBS1585 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005355.1:208219-208809:+ | gene-YML028W_CBS436 | rna-NM_001182386.1_CBS436 | cds-NP_013684.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005339.1:316420-317010:+ | gene-YML028W_CBS6412 | rna-NM_001182386.1_CBS6412 | cds-NP_013684.1_CBS6412 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005323.1:201939-202529:+ | gene-YML028W_CBS6413 | rna-NM_001182386.1_CBS6413 | cds-NP_013684.1_CBS6413 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001534.1:214661-215251:+ | gene-YML028W_CENPK1137D | rna-NM_001182386.1_CENPK1137D | cds-NP_013684.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005483.1:202708-203298:+ | gene-YML028W_EthanolRed | rna-NM_001182386.1_EthanolRed | cds-NP_013684.1_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005547.1:205672-206262:+ | gene-YML028W_FaliES1 | rna-NM_001182386.1_FaliES1 | cds-NP_013684.1_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000237.1:5875-6465:- | gene-YML028W_JAY291 | rna-NM_001182386.1_JAY291 | cds-NP_013684.1_JAY291 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005419.1:207418-208008:+ | gene-YML028W_MUCL30387 | rna-NM_001182386.1_MUCL30387 | cds-NP_013684.1_MUCL30387 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005451.1:211395-211985:+ | gene-YML028W_MUCL30388 | rna-NM_001182386.1_MUCL30388 | cds-NP_013684.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005291.1:202967-203557:+ | gene-YML028W_MUCL39482 | rna-NM_001182386.1_MUCL39482 | cds-NP_013684.1_MUCL39482 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005435.1:208524-209114:+ | gene-YML028W_MUCL42920 | rna-NM_001182386.1_MUCL42920 | cds-NP_013684.1_MUCL42920 | 99.4 | 100.0 | Unannotated | 1 | 1 | 0 | False | False | False | False | True |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011822.1:220092-220682:+ | gene-YML028W_NCIM3186 | rna-NM_001182386.1_NCIM3186 | cds-NP_013684.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005275.1:202910-203500:+ | gene-YML028W_NCYC1407 | rna-NM_001182386.1_NCYC1407 | cds-NP_013684.1_NCYC1407 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994152.1:208810-209400:+ | gene-YML028W_PE2H3 | rna-NM_001182386.1_PE2H3 | cds-NP_013684.1_PE2H3 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999884.1:214905-215495:+ | gene-YML028W_PE2H4 | rna-NM_001182386.1_PE2H4 | cds-NP_013684.1_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001145.3:220138-220728:+ | gene-YML028W_S288C | rna-NM_001182386.1_S288C | cds-NP_013684.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000088.1:18121-18711:- | gene-YML028W_SA1 | rna-NM_001182386.1_SA1 | cds-NP_013684.1_SA1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005499.1:202745-203335:+ | gene-YML028W_ThermosaccDry | rna-NM_001182386.1_ThermosaccDry | cds-NP_013684.1_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005467.1:206751-207341:+ | gene-YML028W_VR1 | rna-NM_001182386.1_VR1 | cds-NP_013684.1_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000027.1:181798-182388:+ | gene-YML028W_ZTW1 | rna-NM_001182386.1_ZTW1 | cds-NP_013684.1_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047499.1:213524-214114:+ | gene-YML028W_Sparadoxus | rna-NM_001182386.1_Sparadoxus | cds-NP_013684.1_Sparadoxus | 95.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |