Gene name: TRX1
Reference locus (S288C): YLR043C
Gene biotype: protein_coding
Description: Thioredoxin-1; Cytoplasmic thioredoxin isoenzyme; part of thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p; required for ER-Golgi transport and vacuole inheritance; with Trx2p, facilitates mitochondrial import of small Tims Tim9p, Tim10p, Tim13p by maintaining them in reduced form; abundance increases iunder DNA replication stress; TRX1 has a paralog, TRX2, that arose from the whole genome duplication
Top 10 interactors (score): TRX2 (0.999); TRR1 (0.996); TSA1 (0.988); TRR2 (0.98); GLR1 (0.973); GRX1 (0.968); GRX2 (0.967); YAP1 (0.964); AHP1 (0.921); GSH1 (0.914); SKN7 (0.91); PRX1 (0.904); MET16 (0.898); HYR1 (0.887); CTA1 (0.886); GPX2 (0.879); RNR1 (0.874); RNR3 (0.874); CTT1 (0.872); GPX1 (0.871)
Homologues (species, bitscore): TXN (Homo sapiens, 97.1); Txn1 (Mus musculus, 88.2); zgc:56493 (Danio rerio, 87.0); LOC100170420 (Xenopus tropicalis, 99.0); Trx-2 (Drosophila melanogaster, 90.5); png-1 (Caenorhabditis elegans, 93.6); TRX2 (Arabidopsis thaliana, 97.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:214189-214500:- | gene-YLR043C_AKU4011 | rna-NM_001181930.1_AKU4011 | cds-NP_013144.1_AKU4011 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000212.1:177336-177647:- | gene-YLR043C_BG1 | rna-NM_001181930.1_BG1 | cds-NP_013144.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:224099-224410:- | gene-YLR043C_Bruggeman | rna-NM_001181930.1_Bruggeman | cds-NP_013144.1_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:224424-224735:- | gene-YLR043C_CAT1 | rna-NM_001181930.1_CAT1 | cds-NP_013144.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:221327-221638:- | gene-YLR043C_CBS1585 | rna-NM_001181930.1_CBS1585 | cds-NP_013144.1_CBS1585 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:211962-212273:- | gene-YLR043C_CBS436 | rna-NM_001181930.1_CBS436 | cds-NP_013144.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:219736-220047:- | gene-YLR043C_CBS6412 | rna-NM_001181930.1_CBS6412 | cds-NP_013144.1_CBS6412 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:221588-221899:- | gene-YLR043C_CBS6413 | rna-NM_001181930.1_CBS6413 | cds-NP_013144.1_CBS6413 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:210997-211308:- | gene-YLR043C_CENPK1137D | rna-NM_001181930.1_CENPK1137D | cds-NP_013144.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:213714-214025:- | gene-YLR043C_EthanolRed | rna-NM_001181930.1_EthanolRed | cds-NP_013144.1_EthanolRed | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:213600-213911:- | gene-YLR043C_FaliES1 | rna-NM_001181930.1_FaliES1 | cds-NP_013144.1_FaliES1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000289.1:1659-1970:+ | gene-YLR043C_JAY291 | rna-NM_001181930.1_JAY291 | cds-NP_013144.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:221450-221761:- | gene-YLR043C_MUCL30387 | rna-NM_001181930.1_MUCL30387 | cds-NP_013144.1_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:229114-229425:- | gene-YLR043C_MUCL30388 | rna-NM_001181930.1_MUCL30388 | cds-NP_013144.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:221822-222133:- | gene-YLR043C_MUCL39482 | rna-NM_001181930.1_MUCL39482 | cds-NP_013144.1_MUCL39482 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:221728-222039:- | gene-YLR043C_MUCL42920 | rna-NM_001181930.1_MUCL42920 | cds-NP_013144.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:231676-231987:- | gene-YLR043C_NCIM3186 | rna-NM_001181930.1_NCIM3186 | cds-NP_013144.1_NCIM3186 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:213881-214192:- | gene-YLR043C_NCYC1407 | rna-NM_001181930.1_NCYC1407 | cds-NP_013144.1_NCYC1407 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:219758-220069:- | gene-YLR043C_PE2H3 | rna-NM_001181930.1_PE2H3 | cds-NP_013144.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:219499-219810:- | gene-YLR043C_PE2H4 | rna-NM_001181930.1_PE2H4 | cds-NP_013144.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:231702-232013:- | gene-YLR043C_S288C | rna-NM_001181930.1_S288C | cds-NP_013144.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000046.1:57601-57912:- | gene-YLR043C_SA1 | rna-NM_001181930.1_SA1 | cds-NP_013144.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:213788-214099:- | gene-YLR043C_ThermosaccDry | rna-NM_001181930.1_ThermosaccDry | cds-NP_013144.1_ThermosaccDry | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:227206-227517:- | gene-YLR043C_VR1 | rna-NM_001181930.1_VR1 | cds-NP_013144.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000023.1:213134-213445:- | gene-YLR043C_ZTW1 | rna-NM_001181930.1_ZTW1 | cds-NP_013144.1_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:222016-222327:- | gene-YLR043C_Sparadoxus | rna-NM_001181930.1_Sparadoxus | cds-NP_013144.1_Sparadoxus | 95.1 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |