Gene name: TRM5
Reference locus (S288C): YHR070W
Gene biotype: protein_coding
Description: tRNA(m(1)G37)methyltransferase; methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; localized to both cytoplasm and mitochondria, and modifies both cytoplasmic and mitochondrial tRNAs; mutations in human ortholog TRMT5 are associated with skeletal muscle respiratory chain deficiencies, and trm5 mutations analogous to disease mutations decrease respiration; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family
Top 10 interactors (score): TYW1 (0.998); TYW3 (0.993); PPM2 (0.993); TRM10 (0.992); TRM12 (0.991); TRM8 (0.979); TRM7 (0.972); GCD14 (0.972); GCD10 (0.96); TRM82 (0.956); NCL1 (0.952); TRM9 (0.948); TRM1 (0.944); SMM1 (0.92); TAD1 (0.918); SUA5 (0.918); TRM11 (0.918); DEG1 (0.902); TAD3 (0.894); TAD2 (0.891)
Homologues (species, bitscore): TRMT5 (Homo sapiens, 245.4); Trmt5 (Mus musculus, 254.2); trmt5 (Danio rerio, 264.6); trmt5 (Xenopus tropicalis, 243.0); CG32281 (Drosophila melanogaster, 216.1); C53A5.17 (Caenorhabditis elegans, 167.5); AT3G56120 (Arabidopsis thaliana, 227.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005302.1:221156-222655:+ | gene-YHR070W_AKU4011 | rna-NM_001179200.1_AKU4011 | cds-NP_011937.1_AKU4011 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000053.1:142589-144088:+ | gene-YHR070W_BG1 | rna-NM_001179200.1_BG1 | cds-NP_011937.1_BG1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005510.1:228895-230393:+ | gene-YHR070W_Bruggeman | rna-NM_001179200.1_Bruggeman | cds-NP_011937.1_Bruggeman | 87.0 | 99.9 | Verified | 1 | 1 | 0 | False | False | False | True | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005526.1:223702-225201:+ | gene-YHR070W_CAT1 | rna-NM_001179200.1_CAT1 | cds-NP_011937.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005366.1:220265-221764:+ | gene-YHR070W_CBS1585 | rna-NM_001179200.1_CBS1585 | cds-NP_011937.1_CBS1585 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005350.1:218207-219706:+ | gene-YHR070W_CBS436 | rna-NM_001179200.1_CBS436 | cds-NP_011937.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005328.1:220477-221976:+ | gene-YHR070W_CBS6412 | rna-NM_001179200.1_CBS6412 | cds-NP_011937.1_CBS6412 | 99.0 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005318.1:221308-222807:+ | gene-YHR070W_CBS6413 | rna-NM_001179200.1_CBS6413 | cds-NP_011937.1_CBS6413 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001529.1:228042-229541:+ | gene-YHR070W_CENPK1137D | rna-NM_001179200.1_CENPK1137D | cds-NP_011937.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005478.1:280822-282321:+ | gene-YHR070W_EthanolRed | rna-NM_001179200.1_EthanolRed | cds-NP_011937.1_EthanolRed | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005542.1:221618-223117:+ | gene-YHR070W_FaliES1 | rna-NM_001179200.1_FaliES1 | cds-NP_011937.1_FaliES1 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000394.1:4370-5869:+ | gene-YHR070W_JAY291 | rna-NM_001179200.1_JAY291 | cds-NP_011937.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005414.1:228633-230132:+ | gene-YHR070W_MUCL30387 | rna-NM_001179200.1_MUCL30387 | cds-NP_011937.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005446.1:228533-230032:+ | gene-YHR070W_MUCL30388 | rna-NM_001179200.1_MUCL30388 | cds-NP_011937.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005286.1:220531-222030:+ | gene-YHR070W_MUCL39482 | rna-NM_001179200.1_MUCL39482 | cds-NP_011937.1_MUCL39482 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005430.1:227410-228909:+ | gene-YHR070W_MUCL42920 | rna-NM_001179200.1_MUCL42920 | cds-NP_011937.1_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011817.1:234763-236262:+ | gene-YHR070W_NCIM3186 | rna-NM_001179200.1_NCIM3186 | cds-NP_011937.1_NCIM3186 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:692172-693671:+ | gene-YHR070W_NCYC1407 | rna-NM_001179200.1_NCYC1407 | cds-NP_011937.1_NCYC1407 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994147.1:222736-224235:+ | gene-YHR070W_PE2H3 | rna-NM_001179200.1_PE2H3 | cds-NP_011937.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999879.1:230183-231682:+ | gene-YHR070W_PE2H4 | rna-NM_001179200.1_PE2H4 | cds-NP_011937.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001140.6:234881-236380:+ | gene-YHR070W_S288C | rna-NM_001179200.1_S288C | cds-NP_011937.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000014.1:123045-124544:- | gene-YHR070W_SA1 | rna-NM_001179200.1_SA1 | cds-NP_011937.1_SA1 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005494.1:222720-224219:+ | gene-YHR070W_ThermosaccDry | rna-NM_001179200.1_ThermosaccDry | cds-NP_011937.1_ThermosaccDry | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005462.1:230342-231841:+ | gene-YHR070W_VR1 | rna-NM_001179200.1_VR1 | cds-NP_011937.1_VR1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000017.1:214271-215770:+ | gene-YHR070W_ZTW1 | rna-NM_001179200.1_ZTW1 | cds-NP_011937.1_ZTW1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047494.1:219845-221344:+ | gene-YHR070W_Sparadoxus | rna-NM_001179200.1_Sparadoxus | cds-NP_011937.1_Sparadoxus | 90.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |