Gene name: TPO1
Reference locus (S288C): YLL028W
Gene biotype: protein_coding
Description: Mfs transporter, dha1 family, multidrug resistance protein; Polyamine transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; during oxidative stress exports spermine, spermidine from the cell, which controls timing of expression of stress-responsive genes; phosphorylation enhances activity and sorting to the plasma membrane; Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter [...]
Top 10 interactors (score): QDR2 (0.944); PDR5 (0.924); AQR1 (0.907); QDR1 (0.907); SNQ2 (0.874); PDR12 (0.851); PDR15 (0.841); TPO5 (0.778); PDR3 (0.766); PDR1 (0.752); PDR16 (0.747); PDR10 (0.743); SAM3 (0.735); YOR1 (0.725); PDR18 (0.722); ATR1 (0.713); DUR3 (0.713); YAP1 (0.702); HAL9 (0.627); TBS1 (0.623)
Homologues (species, bitscore): SPNS3 (Homo sapiens, 51.6); Spns3 (Mus musculus, 57.8); rtet (Drosophila melanogaster, 53.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:71967-73727:+ | gene-YLL028W_AKU4011 | rna-NM_001181848.1_AKU4011 | cds-NP_013072.1_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000212.1:35914-37674:+ | gene-YLL028W_BG1 | rna-NM_001181848.1_BG1 | cds-NP_013072.1_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:82221-83981:+ | gene-YLL028W_Bruggeman | rna-NM_001181848.1_Bruggeman | cds-NP_013072.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:82839-84599:+ | gene-YLL028W_CAT1 | rna-NM_001181848.1_CAT1 | cds-NP_013072.1_CAT1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:79664-81424:+ | gene-YLL028W_CBS1585 | rna-NM_001181848.1_CBS1585 | cds-NP_013072.1_CBS1585 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:69864-71624:+ | gene-YLL028W_CBS436 | rna-NM_001181848.1_CBS436 | cds-NP_013072.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:79581-81341:+ | gene-YLL028W_CBS6412 | rna-NM_001181848.1_CBS6412 | cds-NP_013072.1_CBS6412 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:79675-81435:+ | gene-YLL028W_CBS6413 | rna-NM_001181848.1_CBS6413 | cds-NP_013072.1_CBS6413 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:69811-71571:+ | gene-YLL028W_CENPK1137D | rna-NM_001181848.1_CENPK1137D | cds-NP_013072.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:72361-74121:+ | gene-YLL028W_EthanolRed | rna-NM_001181848.1_EthanolRed | cds-NP_013072.1_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:71674-73434:+ | gene-YLL028W_FaliES1 | rna-NM_001181848.1_FaliES1 | cds-NP_013072.1_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000118.1:5568-7328:- | gene-YLL028W_JAY291 | rna-NM_001181848.1_JAY291 | cds-NP_013072.1_JAY291 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:79633-81393:+ | gene-YLL028W_MUCL30387 | rna-NM_001181848.1_MUCL30387 | cds-NP_013072.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:84361-86121:+ | gene-YLL028W_MUCL30388 | rna-NM_001181848.1_MUCL30388 | cds-NP_013072.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:79873-81633:+ | gene-YLL028W_MUCL39482 | rna-NM_001181848.1_MUCL39482 | cds-NP_013072.1_MUCL39482 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:79973-81733:+ | gene-YLL028W_MUCL42920 | rna-NM_001181848.1_MUCL42920 | cds-NP_013072.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:84778-86538:+ | gene-YLL028W_NCIM3186 | rna-NM_001181848.1_NCIM3186 | cds-NP_013072.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:71760-73519:+ | gene-YLL028W_NCYC1407 | rna-NM_001181848.1_NCYC1407 | cds-NP_013072.1_NCYC1407 | 99.2 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:78426-80186:+ | gene-YLL028W_PE2H3 | rna-NM_001181848.1_PE2H3 | cds-NP_013072.1_PE2H3 | 98.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:78234-79994:+ | gene-YLL028W_PE2H4 | rna-NM_001181848.1_PE2H4 | cds-NP_013072.1_PE2H4 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:84804-86564:+ | gene-YLL028W_S288C | rna-NM_001181848.1_S288C | cds-NP_013072.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000047.1:78347-80107:+ | gene-YLL028W_SA1 | rna-NM_001181848.1_SA1 | cds-NP_013072.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:72180-73940:+ | gene-YLL028W_ThermosaccDry | rna-NM_001181848.1_ThermosaccDry | cds-NP_013072.1_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:86245-88005:+ | gene-YLL028W_VR1 | rna-NM_001181848.1_VR1 | cds-NP_013072.1_VR1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000023.1:71752-73512:+ | gene-YLL028W_ZTW1 | rna-NM_001181848.1_ZTW1 | cds-NP_013072.1_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:80325-82088:+ | gene-YLL028W_Sparadoxus | rna-NM_001181848.1_Sparadoxus | cds-NP_013072.1_Sparadoxus | 91.7 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |