Gene name: TPK3
Reference locus (S288C): YKL166C
Gene biotype: protein_coding
Description: cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication
Top 10 interactors (score): BCY1 (0.999); CYR1 (0.997); RAS2 (0.996); RAS1 (0.987); MSN4 (0.982); PDE2 (0.982); TPK2 (0.979); MSN2 (0.977); TPK1 (0.963); GPA2 (0.935); SLT2 (0.922); SOK2 (0.911); NTH1 (0.892); RIM15 (0.888); CDC25 (0.854); PDE1 (0.854); GPR1 (0.828); IRA2 (0.813); STE4 (0.811); SSN2 (0.794)
Homologues (species, bitscore): PRKACA (Homo sapiens, 345.1); Prkaca (Mus musculus, 345.5); prkacab (Danio rerio, 347.1); prkaca (Xenopus tropicalis, 345.1); Pka-C1 (Drosophila melanogaster, 330.1); kin-1 (Caenorhabditis elegans, 321.2); S6K2 (Arabidopsis thaliana, 250.4)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:121370-122566:- | gene-YKL166C_AKU4011 | rna-NM_001179732.1_AKU4011 | cds-NP_012755.1_AKU4011 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000030.1:97919-99115:- | gene-YKL166C_BG1 | rna-NM_001179732.1_BG1 | cds-NP_012755.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:138772-139968:- | gene-YKL166C_Bruggeman | rna-NM_001179732.1_Bruggeman | cds-NP_012755.1_Bruggeman | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:133715-134911:- | gene-YKL166C_CAT1 | rna-NM_001179732.1_CAT1 | cds-NP_012755.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:133354-134550:- | gene-YKL166C_CBS1585 | rna-NM_001179732.1_CBS1585 | cds-NP_012755.1_CBS1585 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:132111-133307:- | gene-YKL166C_CBS436 | rna-NM_001179732.1_CBS436 | cds-NP_012755.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:118944-120140:- | gene-YKL166C_CBS6412 | rna-NM_001179732.1_CBS6412 | cds-NP_012755.1_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:134070-135266:- | gene-YKL166C_CBS6413 | rna-NM_001179732.1_CBS6413 | cds-NP_012755.1_CBS6413 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:134335-135531:- | gene-YKL166C_CENPK1137D | rna-NM_001179732.1_CENPK1137D | cds-NP_012755.1_CENPK1137D | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:132274-133470:- | gene-YKL166C_EthanolRed | rna-NM_001179732.1_EthanolRed | cds-NP_012755.1_EthanolRed | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:132975-134171:- | gene-YKL166C_FaliES1 | rna-NM_001179732.1_FaliES1 | cds-NP_012755.1_FaliES1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000006.2:131934-133130:- | gene-YKL166C_JAY291 | rna-NM_001179732.1_JAY291 | cds-NP_012755.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:141061-142257:- | gene-YKL166C_MUCL30387 | rna-NM_001179732.1_MUCL30387 | cds-NP_012755.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:135416-136612:- | gene-YKL166C_MUCL30388 | rna-NM_001179732.1_MUCL30388 | cds-NP_012755.1_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:133409-134605:- | gene-YKL166C_MUCL39482 | rna-NM_001179732.1_MUCL39482 | cds-NP_012755.1_MUCL39482 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:137735-138931:- | gene-YKL166C_MUCL42920 | rna-NM_001179732.1_MUCL42920 | cds-NP_012755.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:134498-135694:- | gene-YKL166C_NCIM3186 | rna-NM_001179732.1_NCIM3186 | cds-NP_012755.1_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:133433-134629:- | gene-YKL166C_NCYC1407 | rna-NM_001179732.1_NCYC1407 | cds-NP_012755.1_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:140485-141681:- | gene-YKL166C_PE2H3 | rna-NM_001179732.1_PE2H3 | cds-NP_012755.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:136779-137975:- | gene-YKL166C_PE2H4 | rna-NM_001179732.1_PE2H4 | cds-NP_012755.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:134509-135705:- | gene-YKL166C_S288C | rna-NM_001179732.1_S288C | cds-NP_012755.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000008.1:50709-51905:- | gene-YKL166C_SA1 | rna-NM_001179732.1_SA1 | cds-NP_012755.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:133675-134871:- | gene-YKL166C_ThermosaccDry | rna-NM_001179732.1_ThermosaccDry | cds-NP_012755.1_ThermosaccDry | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:132190-133386:- | gene-YKL166C_VR1 | rna-NM_001179732.1_VR1 | cds-NP_012755.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:132062-133258:- | gene-YKL166C_ZTW1 | rna-NM_001179732.1_ZTW1 | cds-NP_012755.1_ZTW1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:146627-147823:- | gene-YKL166C_Sparadoxus | rna-NM_001179732.1_Sparadoxus | cds-NP_012755.1_Sparadoxus | 92.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |