Gene name: TPK1
Reference locus (S288C): YJL164C
Gene biotype: protein_coding
Description: cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; phosphorylates and inhibits Whi3p to promote G1/S phase passage; partially redundant with Tpk2p and Tpk3p; phosphorylates pre-Tom40p, which impairs its import into mitochondria under non-respiratory conditions; TPK1 has a paralog, TPK3, that arose from the whole genome duplication
Top 10 interactors (score): BCY1 (0.999); CYR1 (0.999); RAS2 (0.998); TPK2 (0.998); RAS1 (0.997); PDE2 (0.984); MSN4 (0.982); MSN2 (0.977); NTH1 (0.976); TPK3 (0.963); CDC25 (0.962); RIM15 (0.957); GPA2 (0.954); SLT2 (0.931); YLR345W (0.928); TSL1 (0.921); GPA1 (0.919); GAD1 (0.917); YAK1 (0.915); SOK2 (0.914)
Homologues (species, bitscore): PRKACB (Homo sapiens, 354.4); Prkaca (Mus musculus, 354.0); prkacb (Danio rerio, 356.3); prkaca (Xenopus tropicalis, 356.3); Pka-C3 (Drosophila melanogaster, 339.3); kin-1 (Caenorhabditis elegans, 324.7); S6K2 (Arabidopsis thaliana, 250.8)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005304.1:98350-99543:- | gene-YJL164C_AKU4011 | rna-NM_001181597.2_AKU4011 | cds-NP_012371.2_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000186.1:10396-11589:- | gene-YJL164C_BG1 | rna-NM_001181597.2_BG1 | cds-NP_012371.2_BG1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005512.1:110181-111374:- | gene-YJL164C_Bruggeman | rna-NM_001181597.2_Bruggeman | cds-NP_012371.2_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005528.1:113653-114846:- | gene-YJL164C_CAT1 | rna-NM_001181597.2_CAT1 | cds-NP_012371.2_CAT1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005368.1:103985-105178:- | gene-YJL164C_CBS1585 | rna-NM_001181597.2_CBS1585 | cds-NP_012371.2_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005352.1:128749-129942:- | gene-YJL164C_CBS436 | rna-NM_001181597.2_CBS436 | cds-NP_012371.2_CBS436 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005336.1:100466-101659:- | gene-YJL164C_CBS6412 | rna-NM_001181597.2_CBS6412 | cds-NP_012371.2_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005320.1:101458-102651:- | gene-YJL164C_CBS6413 | rna-NM_001181597.2_CBS6413 | cds-NP_012371.2_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001531.1:92436-93629:- | gene-YJL164C_CENPK1137D | rna-NM_001181597.2_CENPK1137D | cds-NP_012371.2_CENPK1137D | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005480.1:102644-103837:- | gene-YJL164C_EthanolRed | rna-NM_001181597.2_EthanolRed | cds-NP_012371.2_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005544.1:107913-109106:- | gene-YJL164C_FaliES1 | rna-NM_001181597.2_FaliES1 | cds-NP_012371.2_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000164.1:9607-10800:+ | gene-YJL164C_JAY291 | rna-NM_001181597.2_JAY291 | cds-NP_012371.2_JAY291 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005416.1:111908-113101:- | gene-YJL164C_MUCL30387 | rna-NM_001181597.2_MUCL30387 | cds-NP_012371.2_MUCL30387 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005448.1:108470-109663:- | gene-YJL164C_MUCL30388 | rna-NM_001181597.2_MUCL30388 | cds-NP_012371.2_MUCL30388 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005288.1:102727-103920:- | gene-YJL164C_MUCL39482 | rna-NM_001181597.2_MUCL39482 | cds-NP_012371.2_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005432.1:107336-108529:- | gene-YJL164C_MUCL42920 | rna-NM_001181597.2_MUCL42920 | cds-NP_012371.2_MUCL42920 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011819.1:109945-111138:- | gene-YJL164C_NCIM3186 | rna-NM_001181597.2_NCIM3186 | cds-NP_012371.2_NCIM3186 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005272.1:101336-102529:- | gene-YJL164C_NCYC1407 | rna-NM_001181597.2_NCYC1407 | cds-NP_012371.2_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994149.1:114055-115248:- | gene-YJL164C_PE2H3 | rna-NM_001181597.2_PE2H3 | cds-NP_012371.2_PE2H3 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999881.1:113694-114887:- | gene-YJL164C_PE2H4 | rna-NM_001181597.2_PE2H4 | cds-NP_012371.2_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001142.9:109966-111159:- | gene-YJL164C_S288C | rna-NM_001181597.2_S288C | cds-NP_012371.2_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000022.1:42385-43578:+ | gene-YJL164C_SA1 | rna-NM_001181597.2_SA1 | cds-NP_012371.2_SA1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005496.1:101105-102298:- | gene-YJL164C_ThermosaccDry | rna-NM_001181597.2_ThermosaccDry | cds-NP_012371.2_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005464.1:108004-109197:- | gene-YJL164C_VR1 | rna-NM_001181597.2_VR1 | cds-NP_012371.2_VR1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000021.1:88635-89828:- | gene-YJL164C_ZTW1 | rna-NM_001181597.2_ZTW1 | cds-NP_012371.2_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047496.1:113159-114352:- | gene-YJL164C_Sparadoxus | rna-NM_001181597.2_Sparadoxus | cds-NP_012371.2_Sparadoxus | 92.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |