Gene name: TPI1
Reference locus (S288C): YDR050C
Gene biotype: protein_coding
Description: Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human homolog TPI1 causes a rare autosomal disease; human TPI1 can complement yeast null mutant
Top 10 interactors (score): GPM1 (0.999); PGI1 (0.999); TDH1 (0.999); FBA1 (0.999); TDH2 (0.999); TKL1 (0.999); TDH3 (0.999); PGK1 (0.999); TKL2 (0.998); ENO2 (0.998); CDC19 (0.997); ENO1 (0.997); PGM1 (0.997); TAL1 (0.996); PGM2 (0.996); FUM1 (0.994); AAT1 (0.993); NQM1 (0.993); PFK1 (0.993); ACO1 (0.991)
Homologues (species, bitscore): TPI1 (Homo sapiens, 274.2); Tpi1 (Mus musculus, 270.4); tpi1a (Danio rerio, 269.6); tpi1 (Xenopus tropicalis, 258.8); Tpi (Drosophila melanogaster, 284.3); tpi-1 (Caenorhabditis elegans, 260.0); TPI (Arabidopsis thaliana, 267.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:533256-534002:- | gene-YDR050C_AKU4011 | rna-NM_001180358.1_AKU4011 | cds-NP_010335.1_AKU4011 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000102.1:21205-21951:+ | gene-YDR050C_BG1 | rna-NM_001180358.1_BG1 | cds-NP_010335.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:565604-566350:- | gene-YDR050C_Bruggeman | rna-NM_001180358.1_Bruggeman | cds-NP_010335.1_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:548608-549354:- | gene-YDR050C_CAT1 | rna-NM_001180358.1_CAT1 | cds-NP_010335.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:524212-524958:- | gene-YDR050C_CBS1585 | rna-NM_001180358.1_CBS1585 | cds-NP_010335.1_CBS1585 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:549382-550128:- | gene-YDR050C_CBS436 | rna-NM_001180358.1_CBS436 | cds-NP_010335.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:520624-521370:- | gene-YDR050C_CBS6412 | rna-NM_001180358.1_CBS6412 | cds-NP_010335.1_CBS6412 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:549293-550039:- | gene-YDR050C_CBS6413 | rna-NM_001180358.1_CBS6413 | cds-NP_010335.1_CBS6413 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:554700-555446:- | gene-YDR050C_CENPK1137D | rna-NM_001180358.1_CENPK1137D | cds-NP_010335.1_CENPK1137D | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:535084-535830:- | gene-YDR050C_EthanolRed | rna-NM_001180358.1_EthanolRed | cds-NP_010335.1_EthanolRed | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:541524-542270:- | gene-YDR050C_FaliES1 | rna-NM_001180358.1_FaliES1 | cds-NP_010335.1_FaliES1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000246.1:12439-13185:+ | gene-YDR050C_JAY291 | rna-NM_001180358.1_JAY291 | cds-NP_010335.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:550268-551014:- | gene-YDR050C_MUCL30387 | rna-NM_001180358.1_MUCL30387 | cds-NP_010335.1_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:540685-541431:- | gene-YDR050C_MUCL30388 | rna-NM_001180358.1_MUCL30388 | cds-NP_010335.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:525583-526329:- | gene-YDR050C_MUCL39482 | rna-NM_001180358.1_MUCL39482 | cds-NP_010335.1_MUCL39482 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:455813-456559:- | gene-YDR050C_MUCL42920 | rna-NM_001180358.1_MUCL42920 | cds-NP_010335.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:555649-556395:- | gene-YDR050C_NCIM3186 | rna-NM_001180358.1_NCIM3186 | cds-NP_010335.1_NCIM3186 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:524518-525264:- | gene-YDR050C_NCYC1407 | rna-NM_001180358.1_NCYC1407 | cds-NP_010335.1_NCYC1407 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:544150-544896:- | gene-YDR050C_PE2H3 | rna-NM_001180358.1_PE2H3 | cds-NP_010335.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:543455-544201:- | gene-YDR050C_PE2H4 | rna-NM_001180358.1_PE2H4 | cds-NP_010335.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:555726-556472:- | gene-YDR050C_S288C | rna-NM_001180358.1_S288C | cds-NP_010335.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000011.1:89018-89764:+ | gene-YDR050C_SA1 | rna-NM_001180358.1_SA1 | cds-NP_010335.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:541260-542006:- | gene-YDR050C_ThermosaccDry | rna-NM_001180358.1_ThermosaccDry | cds-NP_010335.1_ThermosaccDry | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:553964-554710:- | gene-YDR050C_VR1 | rna-NM_001180358.1_VR1 | cds-NP_010335.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000006.1:538868-539614:- | gene-YDR050C_ZTW1 | rna-NM_001180358.1_ZTW1 | cds-NP_010335.1_ZTW1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:543268-544014:- | gene-YDR050C_Sparadoxus | rna-NM_001180358.1_Sparadoxus | cds-NP_010335.1_Sparadoxus | 97.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |