Gene name: TPA1
Reference locus (S288C): YER049W
Gene biotype: protein_coding
Description: Prolyl 3,4-dihydroxylase TPA1; Fe(II)/2-oxoglutarate-dependent dioxygenase family member; catalyzes the repair of methyl-base lesions in both ss and dsDNA by oxidative demethylation; Poly(rA)-binding protein involved in mRNA poly(A) tail length and mRNA stability; role in translation termination efficiency; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to human prolyl 4-hydroxylase OGFOD1; binds Fe(II) and 2-oxoglutarate
Top 10 interactors (score): PAB1 (0.952); HMS1 (0.945); ETT1 (0.923); SUP35 (0.874); YEF3 (0.864); SUP45 (0.83); RBG2 (0.802); TRM1 (0.791); BNA2 (0.786); ARX1 (0.78); GCN1 (0.721); NOP2 (0.72); RPS23A (0.715); RPS23B (0.698); DML1 (0.684); YMR114C (0.679); YCR087C-A (0.672); LCP5 (0.671); DBP3 (0.667); SUI1 (0.652)
Homologues (species, bitscore): OGFOD1 (Homo sapiens, 94.4); Ogfod1 (Mus musculus, 83.6); ogfod1 (Danio rerio, 79.7); ogfod1 (Xenopus tropicalis, 94.0); C17G10.1 (Caenorhabditis elegans, 80.9)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005299.1:245529-247463:+ | gene-YER049W_AKU4011 | rna-NM_001178940.1_AKU4011 | cds-NP_010969.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000011.1:178343-180277:- | gene-YER049W_BG1 | rna-NM_001178940.1_BG1 | cds-NP_010969.1_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005507.1:254321-256255:+ | gene-YER049W_Bruggeman | rna-NM_001178940.1_Bruggeman | cds-NP_010969.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005523.1:248471-250405:+ | gene-YER049W_CAT1 | rna-NM_001178940.1_CAT1 | cds-NP_010969.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005363.1:245375-247309:+ | gene-YER049W_CBS1585 | rna-NM_001178940.1_CBS1585 | cds-NP_010969.1_CBS1585 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005347.1:247291-249225:+ | gene-YER049W_CBS436 | rna-NM_001178940.1_CBS436 | cds-NP_010969.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005331.1:244844-246778:+ | gene-YER049W_CBS6412 | rna-NM_001178940.1_CBS6412 | cds-NP_010969.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005315.1:250869-252803:+ | gene-YER049W_CBS6413 | rna-NM_001178940.1_CBS6413 | cds-NP_010969.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001526.1:249588-251522:+ | gene-YER049W_CENPK1137D | rna-NM_001178940.1_CENPK1137D | cds-NP_010969.1_CENPK1137D | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005475.1:245855-247789:+ | gene-YER049W_EthanolRed | rna-NM_001178940.1_EthanolRed | cds-NP_010969.1_EthanolRed | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005539.1:246325-248259:+ | gene-YER049W_FaliES1 | rna-NM_001178940.1_FaliES1 | cds-NP_010969.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000192.1:44083-46017:+ | gene-YER049W_JAY291 | rna-NM_001178940.1_JAY291 | cds-NP_010969.1_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005411.1:249779-251713:+ | gene-YER049W_MUCL30387 | rna-NM_001178940.1_MUCL30387 | cds-NP_010969.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005443.1:245948-247882:+ | gene-YER049W_MUCL30388 | rna-NM_001178940.1_MUCL30388 | cds-NP_010969.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005283.1:244397-246331:+ | gene-YER049W_MUCL39482 | rna-NM_001178940.1_MUCL39482 | cds-NP_010969.1_MUCL39482 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005427.1:251462-253396:+ | gene-YER049W_MUCL42920 | rna-NM_001178940.1_MUCL42920 | cds-NP_010969.1_MUCL42920 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011814.1:251727-253661:+ | gene-YER049W_NCIM3186 | rna-NM_001178940.1_NCIM3186 | cds-NP_010969.1_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005267.1:249479-251413:+ | gene-YER049W_NCYC1407 | rna-NM_001178940.1_NCYC1407 | cds-NP_010969.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994144.1:260108-262042:+ | gene-YER049W_PE2H3 | rna-NM_001178940.1_PE2H3 | cds-NP_010969.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999876.1:250049-251983:+ | gene-YER049W_PE2H4 | rna-NM_001178940.1_PE2H4 | cds-NP_010969.1_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001137.3:251728-253662:+ | gene-YER049W_S288C | rna-NM_001178940.1_S288C | cds-NP_010969.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000059.1:38195-40129:+ | gene-YER049W_SA1 | rna-NM_001178940.1_SA1 | cds-NP_010969.1_SA1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005491.1:247115-249049:+ | gene-YER049W_ThermosaccDry | rna-NM_001178940.1_ThermosaccDry | cds-NP_010969.1_ThermosaccDry | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005459.1:246185-248119:+ | gene-YER049W_VR1 | rna-NM_001178940.1_VR1 | cds-NP_010969.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000009.1:244303-246237:+ | gene-YER049W_ZTW1 | rna-NM_001178940.1_ZTW1 | cds-NP_010969.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047491.1:248144-250078:+ | gene-YER049W_Sparadoxus | rna-NM_001178940.1_Sparadoxus | cds-NP_010969.1_Sparadoxus | 91.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |