Gene name: TOS3
Reference locus (S288C): YGL179C
Gene biotype: protein_coding
Description: Serine/threonine-protein kinase TOS3; Protein kinase; related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome; TOS3 has a paralog, SAK1, that arose from the whole genome duplication
Top 10 interactors (score): ELM1 (0.969); SAK1 (0.964); SNF4 (0.962); GAL83 (0.946); CMD1 (0.936); SNF1 (0.932); SIP1 (0.916); SIP2 (0.911); ATG1 (0.841); GLC7 (0.834); TOS1 (0.777); MIG1 (0.76); BCY1 (0.717); MIH1 (0.715); CMK1 (0.709); CMK2 (0.705); SIP4 (0.661); BMH1 (0.657); NNK1 (0.656); TOS2 (0.651)
Homologues (species, bitscore): CAMKK2 (Homo sapiens, 193.7); Camkk2 (Mus musculus, 195.7); camkk1 (Danio rerio, 194.9); camkk1 (Xenopus tropicalis, 199.1); sff (Drosophila melanogaster, 145.6); ckk-1 (Caenorhabditis elegans, 166.0); GRIK2 (Arabidopsis thaliana, 173.3)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005301.1:165976-167658:- | gene-YGL179C_AKU4011 | rna-NM_001181044.3_AKU4011 | cds-NP_011336.3_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000132.1:242800-244482:+ | gene-YGL179C_BG1 | rna-NM_001181044.3_BG1 | cds-NP_011336.3_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005509.1:168176-169858:- | gene-YGL179C_Bruggeman | rna-NM_001181044.3_Bruggeman | cds-NP_011336.3_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005525.1:164042-165724:- | gene-YGL179C_CAT1 | rna-NM_001181044.3_CAT1 | cds-NP_011336.3_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005365.1:169115-170797:- | gene-YGL179C_CBS1585 | rna-NM_001181044.3_CBS1585 | cds-NP_011336.3_CBS1585 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005349.1:164072-165754:- | gene-YGL179C_CBS436 | rna-NM_001181044.3_CBS436 | cds-NP_011336.3_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005333.1:155577-157259:- | gene-YGL179C_CBS6412 | rna-NM_001181044.3_CBS6412 | cds-NP_011336.3_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005317.1:163427-165109:- | gene-YGL179C_CBS6413 | rna-NM_001181044.3_CBS6413 | cds-NP_011336.3_CBS6413 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001528.1:163600-165282:- | gene-YGL179C_CENPK1137D | rna-NM_001181044.3_CENPK1137D | cds-NP_011336.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005477.1:155782-157464:- | gene-YGL179C_EthanolRed | rna-NM_001181044.3_EthanolRed | cds-NP_011336.3_EthanolRed | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005541.1:157029-158711:- | gene-YGL179C_FaliES1 | rna-NM_001181044.3_FaliES1 | cds-NP_011336.3_FaliES1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000090.1:7267-8949:- | gene-YGL179C_JAY291 | rna-NM_001181044.3_JAY291 | cds-NP_011336.3_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005413.1:165419-167101:- | gene-YGL179C_MUCL30387 | rna-NM_001181044.3_MUCL30387 | cds-NP_011336.3_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005445.1:168511-170193:- | gene-YGL179C_MUCL30388 | rna-NM_001181044.3_MUCL30388 | cds-NP_011336.3_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005285.1:166138-167820:- | gene-YGL179C_MUCL39482 | rna-NM_001181044.3_MUCL39482 | cds-NP_011336.3_MUCL39482 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005429.1:168726-170408:- | gene-YGL179C_MUCL42920 | rna-NM_001181044.3_MUCL42920 | cds-NP_011336.3_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011816.1:163409-165091:- | gene-YGL179C_NCIM3186 | rna-NM_001181044.3_NCIM3186 | cds-NP_011336.3_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005269.1:157604-159286:- | gene-YGL179C_NCYC1407 | rna-NM_001181044.3_NCYC1407 | cds-NP_011336.3_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994146.1:159566-161248:- | gene-YGL179C_PE2H3 | rna-NM_001181044.3_PE2H3 | cds-NP_011336.3_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999878.1:159114-160796:- | gene-YGL179C_PE2H4 | rna-NM_001181044.3_PE2H4 | cds-NP_011336.3_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001139.9:163409-165091:- | gene-YGL179C_S288C | rna-NM_001181044.3_S288C | cds-NP_011336.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000067.1:23167-24849:- | gene-YGL179C_SA1 | rna-NM_001181044.3_SA1 | cds-NP_011336.3_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005493.1:157259-158941:- | gene-YGL179C_ThermosaccDry | rna-NM_001181044.3_ThermosaccDry | cds-NP_011336.3_ThermosaccDry | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005461.1:164468-166150:- | gene-YGL179C_VR1 | rna-NM_001181044.3_VR1 | cds-NP_011336.3_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000014.1:155695-157377:- | gene-YGL179C_ZTW1 | rna-NM_001181044.3_ZTW1 | cds-NP_011336.3_ZTW1 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047493.1:162539-164221:- | gene-YGL179C_Sparadoxus | rna-NM_001181044.3_Sparadoxus | cds-NP_011336.3_Sparadoxus | 87.5 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |