Gene name: TOP3
Reference locus (S288C): YLR234W
Gene biotype: protein_coding
Description: DNA Topoisomerase III; conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially; DNA catenation/decatenation activity is stimulated by RPA and Sgs1p-Top3p-Rmi1p; involved in telomere stability and regulation of mitotic recombination
Top 10 interactors (score): RAD1 (0.999); MUS81 (0.999); SGS1 (0.999); RMI1 (0.999); DNA2 (0.997); RAD51 (0.997); TOP1 (0.996); RAD27 (0.995); SRS2 (0.993); MPH1 (0.991); TOP2 (0.99); SLX1 (0.984); RAD54 (0.984); RAD52 (0.982); EXO1 (0.978); MMS4 (0.971); SMC5 (0.97); SMC6 (0.961); MSH6 (0.954); SPO11 (0.952)
Homologues (species, bitscore): TOP3A (Homo sapiens, 458.8); Top3a (Mus musculus, 456.4); top3a (Danio rerio, 463.8); top3a (Xenopus tropicalis, 465.7); Top3alpha (Drosophila melanogaster, 395.2); top-3 (Caenorhabditis elegans, 437.6); TOP3A (Arabidopsis thaliana, 416.0)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:563948-565918:+ | gene-YLR234W_AKU4011 | rna-NM_001182121.1_AKU4011 | cds-NP_013335.1_AKU4011 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000082.1:18006-19976:+ | gene-YLR234W_BG1 | rna-NM_001182121.1_BG1 | cds-NP_013335.1_BG1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:598231-600201:+ | gene-YLR234W_Bruggeman | rna-NM_001182121.1_Bruggeman | cds-NP_013335.1_Bruggeman | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:597352-599322:+ | gene-YLR234W_CAT1 | rna-NM_001182121.1_CAT1 | cds-NP_013335.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:599442-601412:+ | gene-YLR234W_CBS1585 | rna-NM_001182121.1_CBS1585 | cds-NP_013335.1_CBS1585 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:583697-585667:+ | gene-YLR234W_CBS436 | rna-NM_001182121.1_CBS436 | cds-NP_013335.1_CBS436 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:562417-564387:+ | gene-YLR234W_CBS6412 | rna-NM_001182121.1_CBS6412 | cds-NP_013335.1_CBS6412 | 99.1 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:599737-601707:+ | gene-YLR234W_CBS6413 | rna-NM_001182121.1_CBS6413 | cds-NP_013335.1_CBS6413 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:594394-596364:+ | gene-YLR234W_CENPK1137D | rna-NM_001182121.1_CENPK1137D | cds-NP_013335.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:557529-559499:+ | gene-YLR234W_EthanolRed | rna-NM_001182121.1_EthanolRed | cds-NP_013335.1_EthanolRed | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:586454-588424:+ | gene-YLR234W_FaliES1 | rna-NM_001182121.1_FaliES1 | cds-NP_013335.1_FaliES1 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000136.1:70468-72438:- | gene-YLR234W_JAY291 | rna-NM_001182121.1_JAY291 | cds-NP_013335.1_JAY291 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:599089-601059:+ | gene-YLR234W_MUCL30387 | rna-NM_001182121.1_MUCL30387 | cds-NP_013335.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:603210-605180:+ | gene-YLR234W_MUCL30388 | rna-NM_001182121.1_MUCL30388 | cds-NP_013335.1_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:600423-602393:+ | gene-YLR234W_MUCL39482 | rna-NM_001182121.1_MUCL39482 | cds-NP_013335.1_MUCL39482 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:595231-597201:+ | gene-YLR234W_MUCL42920 | rna-NM_001182121.1_MUCL42920 | cds-NP_013335.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:609757-611727:+ | gene-YLR234W_NCIM3186 | rna-NM_001182121.1_NCIM3186 | cds-NP_013335.1_NCIM3186 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:587412-589382:+ | gene-YLR234W_NCYC1407 | rna-NM_001182121.1_NCYC1407 | cds-NP_013335.1_NCYC1407 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:591171-593141:+ | gene-YLR234W_PE2H3 | rna-NM_001182121.1_PE2H3 | cds-NP_013335.1_PE2H3 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:590915-592885:+ | gene-YLR234W_PE2H4 | rna-NM_001182121.1_PE2H4 | cds-NP_013335.1_PE2H4 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:609783-611753:+ | gene-YLR234W_S288C | rna-NM_001182121.1_S288C | cds-NP_013335.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000013.1:70719-72689:- | gene-YLR234W_SA1 | rna-NM_001182121.1_SA1 | cds-NP_013335.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:588954-590924:+ | gene-YLR234W_ThermosaccDry | rna-NM_001182121.1_ThermosaccDry | cds-NP_013335.1_ThermosaccDry | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:600286-602256:+ | gene-YLR234W_VR1 | rna-NM_001182121.1_VR1 | cds-NP_013335.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000024.1:113271-115241:+ | gene-YLR234W_ZTW1 | rna-NM_001182121.1_ZTW1 | cds-NP_013335.1_ZTW1 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:574422-576392:+ | gene-YLR234W_Sparadoxus | rna-NM_001182121.1_Sparadoxus | cds-NP_013335.1_Sparadoxus | 91.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |