Gene name: TOP2
Reference locus (S288C): YNL088W
Gene biotype: protein_coding
Description: DNA topoisomerase 2; Topoisomerase II; relieves torsional strain in DNA by cleaving and re-sealing phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis; required for replication slow zone (RSZ) breakage following Mec1p inactivation; human homolog TOP2A implicated in cancers, and can complement yeast null mutant; Belongs to the type II topoisomerase family
Top 10 interactors (score): TOP1 (0.999); BRN1 (0.997); SMC4 (0.996); SGS1 (0.995); SMT3 (0.994); SMC6 (0.993); SMC2 (0.992); UBC9 (0.991); SMC3 (0.99); ESP1 (0.99); TOP3 (0.99); YCG1 (0.983); IPL1 (0.98); TDP1 (0.979); PDS5 (0.976); SMC5 (0.973); DNA2 (0.97); CDC45 (0.966); POL1 (0.963); POL2 (0.962)
Homologues (species, bitscore): TOP2A (Homo sapiens, 1093.6); Top2b (Mus musculus, 1092.8); top2b (Danio rerio, 1075.8); top2a (Xenopus tropicalis, 1001.5); Top2 (Drosophila melanogaster, 1111.7); top-2 (Caenorhabditis elegans, 1063.1); TOPII (Arabidopsis thaliana, 1116.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005308.1:451351-455637:+ | gene-YNL088W_AKU4011 | rna-NM_001182926.3_AKU4011 | cds-NP_014311.3_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000155.1:355436-359722:+ | gene-YNL088W_BG1 | rna-NM_001182926.3_BG1 | cds-NP_014311.3_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:462071-466357:+ | gene-YNL088W_Bruggeman | rna-NM_001182926.3_Bruggeman | cds-NP_014311.3_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:505097-509383:+ | gene-YNL088W_CAT1 | rna-NM_001182926.3_CAT1 | cds-NP_014311.3_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:452021-456307:+ | gene-YNL088W_CBS1585 | rna-NM_001182926.3_CBS1585 | cds-NP_014311.3_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:520412-524698:+ | gene-YNL088W_CBS436 | rna-NM_001182926.3_CBS436 | cds-NP_014311.3_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:447117-451403:+ | gene-YNL088W_CBS6412 | rna-NM_001182926.3_CBS6412 | cds-NP_014311.3_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:448433-452719:+ | gene-YNL088W_CBS6413 | rna-NM_001182926.3_CBS6413 | cds-NP_014311.3_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:451528-455814:+ | gene-YNL088W_CENPK1137D | rna-NM_001182926.3_CENPK1137D | cds-NP_014311.3_CENPK1137D | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:454176-458462:+ | gene-YNL088W_EthanolRed | rna-NM_001182926.3_EthanolRed | cds-NP_014311.3_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:444705-448991:+ | gene-YNL088W_FaliES1 | rna-NM_001182926.3_FaliES1 | cds-NP_014311.3_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000317.1:24607-28893:- | gene-YNL088W_JAY291 | rna-NM_001182926.3_JAY291 | cds-NP_014311.3_JAY291 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:458248-462534:+ | gene-YNL088W_MUCL30387 | rna-NM_001182926.3_MUCL30387 | cds-NP_014311.3_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:493620-497906:+ | gene-YNL088W_MUCL30388 | rna-NM_001182926.3_MUCL30388 | cds-NP_014311.3_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:449425-453711:+ | gene-YNL088W_MUCL39482 | rna-NM_001182926.3_MUCL39482 | cds-NP_014311.3_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:453363-457649:+ | gene-YNL088W_MUCL42920 | rna-NM_001182926.3_MUCL42920 | cds-NP_014311.3_MUCL42920 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:457673-461959:+ | gene-YNL088W_NCIM3186 | rna-NM_001182926.3_NCIM3186 | cds-NP_014311.3_NCIM3186 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:451473-455759:+ | gene-YNL088W_NCYC1407 | rna-NM_001182926.3_NCYC1407 | cds-NP_014311.3_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:454711-458997:+ | gene-YNL088W_PE2H3 | rna-NM_001182926.3_PE2H3 | cds-NP_014311.3_PE2H3 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:449787-454073:+ | gene-YNL088W_PE2H4 | rna-NM_001182926.3_PE2H4 | cds-NP_014311.3_PE2H4 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:457704-461990:+ | gene-YNL088W_S288C | rna-NM_001182926.3_S288C | cds-NP_014311.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000024.1:42649-46935:+ | gene-YNL088W_SA1 | rna-NM_001182926.3_SA1 | cds-NP_014311.3_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:445580-449866:+ | gene-YNL088W_ThermosaccDry | rna-NM_001182926.3_ThermosaccDry | cds-NP_014311.3_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:464692-468978:+ | gene-YNL088W_VR1 | rna-NM_001182926.3_VR1 | cds-NP_014311.3_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000030.1:354929-359215:+ | gene-YNL088W_ZTW1 | rna-NM_001182926.3_ZTW1 | cds-NP_014311.3_ZTW1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:461077-465369:+ | gene-YNL088W_Sparadoxus | rna-NM_001182926.3_Sparadoxus | cds-NP_014311.3_Sparadoxus | 90.6 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |