Gene name: TOP1
Reference locus (S288C): YOL006C
Gene biotype: protein_coding
Description: DNA topoisomerase 1; Topoisomerase I; nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination; role in processing ribonucleoside monophosphates in genomic DNA into irreversible single-strand breaks; enzymatic activity and interaction with Nsr1p are negatively regulated by polyphosphorylation
Top 10 interactors (score): TOP2 (0.999); TDP1 (0.998); TOP3 (0.996); TOF1 (0.995); SGS1 (0.994); RNH201 (0.993); SPT16 (0.992); CDC45 (0.99); RFA1 (0.989); CTF4 (0.989); CSM3 (0.987); MCM4 (0.986); RAD9 (0.985); UBC9 (0.985); POL30 (0.982); MUS81 (0.982); SMT3 (0.981); POL2 (0.98); MCM10 (0.979); HTB2 (0.974)
Homologues (species, bitscore): TOP1 (Homo sapiens, 563.9); Top1 (Mus musculus, 560.8); top1l (Danio rerio, 553.1); top1.2 (Xenopus tropicalis, 552.4); Top1 (Drosophila melanogaster, 557.4); top-1 (Caenorhabditis elegans, 495.4); TOP1BETA (Arabidopsis thaliana, 504.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005309.1:297440-299749:- | gene-YOL006C_AKU4011 | rna-NM_001183260.1_AKU4011 | cds-NP_014637.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000152.1:113051-115360:- | gene-YOL006C_BG1 | rna-NM_001183260.1_BG1 | cds-NP_014637.1_BG1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005517.1:300257-302566:- | gene-YOL006C_Bruggeman | rna-NM_001183260.1_Bruggeman | cds-NP_014637.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005533.1:298394-300703:- | gene-YOL006C_CAT1 | rna-NM_001183260.1_CAT1 | cds-NP_014637.1_CAT1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005373.1:292116-294425:- | gene-YOL006C_CBS1585 | rna-NM_001183260.1_CBS1585 | cds-NP_014637.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005357.1:296384-298693:- | gene-YOL006C_CBS436 | rna-NM_001183260.1_CBS436 | cds-NP_014637.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005341.1:291467-293776:- | gene-YOL006C_CBS6412 | rna-NM_001183260.1_CBS6412 | cds-NP_014637.1_CBS6412 | 99.6 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005325.1:299000-301309:- | gene-YOL006C_CBS6413 | rna-NM_001183260.1_CBS6413 | cds-NP_014637.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001536.1:312815-315124:- | gene-YOL006C_CENPK1137D | rna-NM_001183260.1_CENPK1137D | cds-NP_014637.1_CENPK1137D | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005485.1:294252-296561:- | gene-YOL006C_EthanolRed | rna-NM_001183260.1_EthanolRed | cds-NP_014637.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005549.1:297579-299888:- | gene-YOL006C_FaliES1 | rna-NM_001183260.1_FaliES1 | cds-NP_014637.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000015.1:29376-31684:+ | gene-YOL006C_JAY291 | rna-NM_001183260.1_JAY291 | cds-NP_014637.1_JAY291 | 99.4 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005421.1:304464-306773:- | gene-YOL006C_MUCL30387 | rna-NM_001183260.1_MUCL30387 | cds-NP_014637.1_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005453.1:307904-310213:- | gene-YOL006C_MUCL30388 | rna-NM_001183260.1_MUCL30388 | cds-NP_014637.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005293.1:299599-301908:- | gene-YOL006C_MUCL39482 | rna-NM_001183260.1_MUCL39482 | cds-NP_014637.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005437.1:314512-316821:- | gene-YOL006C_MUCL42920 | rna-NM_001183260.1_MUCL42920 | cds-NP_014637.1_MUCL42920 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011824.1:312967-315276:- | gene-YOL006C_NCIM3186 | rna-NM_001183260.1_NCIM3186 | cds-NP_014637.1_NCIM3186 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005277.1:306332-308641:- | gene-YOL006C_NCYC1407 | rna-NM_001183260.1_NCYC1407 | cds-NP_014637.1_NCYC1407 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994154.1:300973-303282:- | gene-YOL006C_PE2H3 | rna-NM_001183260.1_PE2H3 | cds-NP_014637.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999886.1:311370-313679:- | gene-YOL006C_PE2H4 | rna-NM_001183260.1_PE2H4 | cds-NP_014637.1_PE2H4 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001147.6:313078-315387:- | gene-YOL006C_S288C | rna-NM_001183260.1_S288C | cds-NP_014637.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000001.1:281060-283369:- | gene-YOL006C_SA1 | rna-NM_001183260.1_SA1 | cds-NP_014637.1_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005501.1:296150-298459:- | gene-YOL006C_ThermosaccDry | rna-NM_001183260.1_ThermosaccDry | cds-NP_014637.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005469.1:296935-299244:- | gene-YOL006C_VR1 | rna-NM_001183260.1_VR1 | cds-NP_014637.1_VR1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000032.1:30816-33125:- | gene-YOL006C_ZTW1 | rna-NM_001183260.1_ZTW1 | cds-NP_014637.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047501.1:304462-306774:- | gene-YOL006C_Sparadoxus | rna-NM_001183260.1_Sparadoxus | cds-NP_014637.1_Sparadoxus | 90.9 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |