Gene name: TOM1
Reference locus (S288C): YDR457W
Gene biotype: protein_coding
Description: E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones; interacts with Dia2p and is required for Dia2p degradation; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase; Belongs to the UPL family. TOM1/PTR1 subfamily
Top 10 interactors (score): TRA1 (0.995); UBI4 (0.983); UFD4 (0.956); YRA1 (0.934); UBR1 (0.903); SEC16 (0.901); FPR3 (0.842); HRT1 (0.838); PRP8 (0.821); YBR062C (0.819); UBR2 (0.819); CSF1 (0.801); RPN6 (0.8); NAB2 (0.788); CUL3 (0.785); SEC7 (0.776); PSH1 (0.776); VPS13 (0.776); RPS31 (0.775); RAD6 (0.758)
Homologues (species, bitscore): HUWE1 (Homo sapiens, 454.5); Huwe1 (Mus musculus, 454.5); huwe1 (Danio rerio, 456.4); HUWE1 (Xenopus tropicalis, 422.9); CG8184 (Drosophila melanogaster, 437.2); eel-1 (Caenorhabditis elegans, 447.2); UPL1 (Arabidopsis thaliana, 462.2)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005298.1:1309695-1319501:+ | gene-YDR457W_AKU4011 | rna-NM_001180765.3_AKU4011 | cds-NP_010745.3_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000039.1:188054-197860:+ | gene-YDR457W_BG1 | rna-NM_001180765.3_BG1 | cds-NP_010745.3_BG1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005506.1:1341127-1350933:+ | gene-YDR457W_Bruggeman | rna-NM_001180765.3_Bruggeman | cds-NP_010745.3_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005522.1:1318277-1328083:+ | gene-YDR457W_CAT1 | rna-NM_001180765.3_CAT1 | cds-NP_010745.3_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005362.1:1304001-1313807:+ | gene-YDR457W_CBS1585 | rna-NM_001180765.3_CBS1585 | cds-NP_010745.3_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005346.1:1323375-1333181:+ | gene-YDR457W_CBS436 | rna-NM_001180765.3_CBS436 | cds-NP_010745.3_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005330.1:1299629-1309435:+ | gene-YDR457W_CBS6412 | rna-NM_001180765.3_CBS6412 | cds-NP_010745.3_CBS6412 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005314.1:1322640-1332446:+ | gene-YDR457W_CBS6413 | rna-NM_001180765.3_CBS6413 | cds-NP_010745.3_CBS6413 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001525.1:1368464-1378270:+ | gene-YDR457W_CENPK1137D | rna-NM_001180765.3_CENPK1137D | cds-NP_010745.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005474.1:1313050-1322856:+ | gene-YDR457W_EthanolRed | rna-NM_001180765.3_EthanolRed | cds-NP_010745.3_EthanolRed | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005538.1:1316603-1326409:+ | gene-YDR457W_FaliES1 | rna-NM_001180765.3_FaliES1 | cds-NP_010745.3_FaliES1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000026.1:14863-24669:+ | gene-YDR457W_JAY291 | rna-NM_001180765.3_JAY291 | cds-NP_010745.3_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005410.1:1323618-1333424:+ | gene-YDR457W_MUCL30387 | rna-NM_001180765.3_MUCL30387 | cds-NP_010745.3_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005442.1:1305642-1315448:+ | gene-YDR457W_MUCL30388 | rna-NM_001180765.3_MUCL30388 | cds-NP_010745.3_MUCL30388 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005282.1:1295485-1305291:+ | gene-YDR457W_MUCL39482 | rna-NM_001180765.3_MUCL39482 | cds-NP_010745.3_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005426.1:1238285-1248091:+ | gene-YDR457W_MUCL42920 | rna-NM_001180765.3_MUCL42920 | cds-NP_010745.3_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011813.1:1369713-1379519:+ | gene-YDR457W_NCIM3186 | rna-NM_001180765.3_NCIM3186 | cds-NP_010745.3_NCIM3186 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005266.1:1309257-1319063:+ | gene-YDR457W_NCYC1407 | rna-NM_001180765.3_NCYC1407 | cds-NP_010745.3_NCYC1407 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994143.1:1320112-1329918:+ | gene-YDR457W_PE2H3 | rna-NM_001180765.3_PE2H3 | cds-NP_010745.3_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999875.1:1325669-1335475:+ | gene-YDR457W_PE2H4 | rna-NM_001180765.3_PE2H4 | cds-NP_010745.3_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001136.10:1369790-1379596:+ | gene-YDR457W_S288C | rna-NM_001180765.3_S288C | cds-NP_010745.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000004.1:237568-247374:- | gene-YDR457W_SA1 | rna-NM_001180765.3_SA1 | cds-NP_010745.3_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005490.1:1320825-1330631:+ | gene-YDR457W_ThermosaccDry | rna-NM_001180765.3_ThermosaccDry | cds-NP_010745.3_ThermosaccDry | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005458.1:1336563-1346369:+ | gene-YDR457W_VR1 | rna-NM_001180765.3_VR1 | cds-NP_010745.3_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000008.1:363502-373307:+ | gene-YDR457W_ZTW1 | rna-NM_001180765.3_ZTW1 | cds-NP_010745.3_ZTW1 | 99.7 | 99.9 | Unannotated | 1 | 1 | 0 | False | False | False | True | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047490.1:1323927-1333730:+ | gene-YDR457W_Sparadoxus | rna-NM_001180765.3_Sparadoxus | cds-NP_010745.3_Sparadoxus | 90.6 | 99.9 | Verified | 1 | 1 | 1 | False | True | False | False | False |