Gene name: TOF2
Reference locus (S288C): YKR010C
Gene biotype: protein_coding
Description: Topoisomerase 1-associated factor 2; Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site; TOF2 has a paralog, NET1, that arose from the whole genome duplication; To yeast YJL076w
Top 10 interactors (score): NET1 (0.999); LRS4 (0.975); FOB1 (0.972); CSM1 (0.967); CDC14 (0.965); CTF4 (0.937); SIR2 (0.925); NUR1 (0.898); SRC1 (0.776); NFI1 (0.673); DOP1 (0.671); TOP1 (0.661); ULP2 (0.66); NOP53 (0.656); SPO12 (0.617); SMC2 (0.611); UBC9 (0.607); SLX8 (0.573); SLD5 (0.556); YCS4 (0.545)
Homologues (species, bitscore): Unknown
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005305.1:444587-446902:- | gene-YKR010C_AKU4011 | rna-NM_001179800.3_AKU4011 | cds-NP_012935.3_AKU4011 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000113.1:196672-198987:+ | gene-YKR010C_BG1 | rna-NM_001179800.3_BG1 | cds-NP_012935.3_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005513.1:466288-468603:- | gene-YKR010C_Bruggeman | rna-NM_001179800.3_Bruggeman | cds-NP_012935.3_Bruggeman | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005529.1:461979-464294:- | gene-YKR010C_CAT1 | rna-NM_001179800.3_CAT1 | cds-NP_012935.3_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005369.1:457327-459642:- | gene-YKR010C_CBS1585 | rna-NM_001179800.3_CBS1585 | cds-NP_012935.3_CBS1585 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005353.1:456162-458477:- | gene-YKR010C_CBS436 | rna-NM_001179800.3_CBS436 | cds-NP_012935.3_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005337.1:441485-443800:- | gene-YKR010C_CBS6412 | rna-NM_001179800.3_CBS6412 | cds-NP_012935.3_CBS6412 | 99.4 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005321.1:457159-459474:- | gene-YKR010C_CBS6413 | rna-NM_001179800.3_CBS6413 | cds-NP_012935.3_CBS6413 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001532.1:458595-460910:- | gene-YKR010C_CENPK1137D | rna-NM_001179800.3_CENPK1137D | cds-NP_012935.3_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005481.1:455056-457371:- | gene-YKR010C_EthanolRed | rna-NM_001179800.3_EthanolRed | cds-NP_012935.3_EthanolRed | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005545.1:457989-460304:- | gene-YKR010C_FaliES1 | rna-NM_001179800.3_FaliES1 | cds-NP_012935.3_FaliES1 | 60.4 | 75.6 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000077.1:93441-95756:+ | gene-YKR010C_JAY291 | rna-NM_001179800.3_JAY291 | cds-NP_012935.3_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005417.1:465602-467917:- | gene-YKR010C_MUCL30387 | rna-NM_001179800.3_MUCL30387 | cds-NP_012935.3_MUCL30387 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005449.1:461213-463528:- | gene-YKR010C_MUCL30388 | rna-NM_001179800.3_MUCL30388 | cds-NP_012935.3_MUCL30388 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005289.1:456644-458959:- | gene-YKR010C_MUCL39482 | rna-NM_001179800.3_MUCL39482 | cds-NP_012935.3_MUCL39482 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005433.1:462449-464764:- | gene-YKR010C_MUCL42920 | rna-NM_001179800.3_MUCL42920 | cds-NP_012935.3_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011820.1:458913-461228:- | gene-YKR010C_NCIM3186 | rna-NM_001179800.3_NCIM3186 | cds-NP_012935.3_NCIM3186 | 98.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005273.1:456852-459167:- | gene-YKR010C_NCYC1407 | rna-NM_001179800.3_NCYC1407 | cds-NP_012935.3_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994150.1:481837-484152:- | gene-YKR010C_PE2H3 | rna-NM_001179800.3_PE2H3 | cds-NP_012935.3_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999882.1:466579-468894:- | gene-YKR010C_PE2H4 | rna-NM_001179800.3_PE2H4 | cds-NP_012935.3_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001143.9:458924-461239:- | gene-YKR010C_S288C | rna-NM_001179800.3_S288C | cds-NP_012935.3_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000078.1:52545-54860:+ | gene-YKR010C_SA1 | rna-NM_001179800.3_SA1 | cds-NP_012935.3_SA1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005497.1:457243-459558:- | gene-YKR010C_ThermosaccDry | rna-NM_001179800.3_ThermosaccDry | cds-NP_012935.3_ThermosaccDry | 99.2 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005465.1:456860-459175:- | gene-YKR010C_VR1 | rna-NM_001179800.3_VR1 | cds-NP_012935.3_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000022.1:455292-457607:- | gene-YKR010C_ZTW1 | rna-NM_001179800.3_ZTW1 | cds-NP_012935.3_ZTW1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047497.1:480763-483078:- | gene-YKR010C_Sparadoxus | rna-NM_001179800.3_Sparadoxus | cds-NP_012935.3_Sparadoxus | 83.7 | 99.3 | Verified | 1 | 1 | 1 | False | True | False | False | False |