Gene name: TOF1
Reference locus (S288C): YNL273W
Gene biotype: protein_coding
Description: Topoisomerase 1-associated factor 1; Subunit of a replication-pausing checkpoint complex; Tof1p-Mrc1p-Csm3p acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase; relocalizes to the cytosol in response to hypoxia
Top 10 interactors (score): MCM7 (0.999); CDC45 (0.999); MCM2 (0.999); MCM6 (0.999); MCM3 (0.999); PSF3 (0.999); MCM5 (0.999); CTF4 (0.999); MCM4 (0.999); CSM3 (0.999); MRC1 (0.999); SGS1 (0.998); MCM10 (0.998); SLD5 (0.998); PHR1 (0.997); CTF18 (0.997); PSF2 (0.995); TOP1 (0.995); CHK1 (0.993); POL2 (0.992)
Homologues (species, bitscore): TIMELESS (Homo sapiens, 70.9); Timeless (Mus musculus, 71.2); timeless (Danio rerio, 51.6); timeless (Xenopus tropicalis, 68.6); ATIM (Arabidopsis thaliana, 50.1)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005308.1:116686-120402:+ | gene-YNL273W_AKU4011 | rna-NM_001183111.1_AKU4011 | cds-NP_014126.1_AKU4011 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000155.1:20569-24285:+ | gene-YNL273W_BG1 | rna-NM_001183111.1_BG1 | cds-NP_014126.1_BG1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005516.1:126479-130195:+ | gene-YNL273W_Bruggeman | rna-NM_001183111.1_Bruggeman | cds-NP_014126.1_Bruggeman | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005532.1:129730-133446:+ | gene-YNL273W_CAT1 | rna-NM_001183111.1_CAT1 | cds-NP_014126.1_CAT1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005372.1:117076-120792:+ | gene-YNL273W_CBS1585 | rna-NM_001183111.1_CBS1585 | cds-NP_014126.1_CBS1585 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005356.1:112158-115874:+ | gene-YNL273W_CBS436 | rna-NM_001183111.1_CBS436 | cds-NP_014126.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005340.1:113498-117214:+ | gene-YNL273W_CBS6412 | rna-NM_001183111.1_CBS6412 | cds-NP_014126.1_CBS6412 | 99.0 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005324.1:113777-117493:+ | gene-YNL273W_CBS6413 | rna-NM_001183111.1_CBS6413 | cds-NP_014126.1_CBS6413 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001535.1:116708-120424:+ | gene-YNL273W_CENPK1137D | rna-NM_001183111.1_CENPK1137D | cds-NP_014126.1_CENPK1137D | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005484.1:114308-118024:+ | gene-YNL273W_EthanolRed | rna-NM_001183111.1_EthanolRed | cds-NP_014126.1_EthanolRed | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005548.1:109045-112761:+ | gene-YNL273W_FaliES1 | rna-NM_001183111.1_FaliES1 | cds-NP_014126.1_FaliES1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000082.1:20277-23993:+ | gene-YNL273W_JAY291 | rna-NM_001183111.1_JAY291 | cds-NP_014126.1_JAY291 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005420.1:122021-125737:+ | gene-YNL273W_MUCL30387 | rna-NM_001183111.1_MUCL30387 | cds-NP_014126.1_MUCL30387 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005452.1:120083-123799:+ | gene-YNL273W_MUCL30388 | rna-NM_001183111.1_MUCL30388 | cds-NP_014126.1_MUCL30388 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005292.1:114566-118282:+ | gene-YNL273W_MUCL39482 | rna-NM_001183111.1_MUCL39482 | cds-NP_014126.1_MUCL39482 | 99.1 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005436.1:116819-120535:+ | gene-YNL273W_MUCL42920 | rna-NM_001183111.1_MUCL42920 | cds-NP_014126.1_MUCL42920 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011823.1:122852-126568:+ | gene-YNL273W_NCIM3186 | rna-NM_001183111.1_NCIM3186 | cds-NP_014126.1_NCIM3186 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005276.1:116433-120149:+ | gene-YNL273W_NCYC1407 | rna-NM_001183111.1_NCYC1407 | cds-NP_014126.1_NCYC1407 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994153.1:113613-117329:+ | gene-YNL273W_PE2H3 | rna-NM_001183111.1_PE2H3 | cds-NP_014126.1_PE2H3 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999885.1:113001-116717:+ | gene-YNL273W_PE2H4 | rna-NM_001183111.1_PE2H4 | cds-NP_014126.1_PE2H4 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001146.8:122883-126599:+ | gene-YNL273W_S288C | rna-NM_001183111.1_S288C | cds-NP_014126.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000034.1:20342-24058:+ | gene-YNL273W_SA1 | rna-NM_001183111.1_SA1 | cds-NP_014126.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005500.1:109902-113618:+ | gene-YNL273W_ThermosaccDry | rna-NM_001183111.1_ThermosaccDry | cds-NP_014126.1_ThermosaccDry | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005468.1:128811-132527:+ | gene-YNL273W_VR1 | rna-NM_001183111.1_VR1 | cds-NP_014126.1_VR1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000030.1:20265-23981:+ | gene-YNL273W_ZTW1 | rna-NM_001183111.1_ZTW1 | cds-NP_014126.1_ZTW1 | 99.0 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047500.1:120140-123856:+ | gene-YNL273W_Sparadoxus | rna-NM_001183111.1_Sparadoxus | cds-NP_014126.1_Sparadoxus | 87.2 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |