Gene name: TKL1
Reference locus (S288C): YPR074C
Gene biotype: protein_coding
Description: Transketolase; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids; TKL1 has a paralog, TKL2, that arose from the whole genome duplication
Top 10 interactors (score): RPE1 (0.999); TPI1 (0.999); TAL1 (0.999); TKL2 (0.999); NQM1 (0.998); RKI1 (0.998); GND1 (0.992); PGI1 (0.989); ZWF1 (0.989); FBA1 (0.987); FBP1 (0.982); CDC19 (0.98); TDH3 (0.972); PFK1 (0.969); RBK1 (0.969); PDB1 (0.967); ENO2 (0.966); ENO1 (0.963); PFK2 (0.962); TDH1 (0.961)
Homologues (species, bitscore): TKT (Homo sapiens, 172.6); Tkt (Mus musculus, 165.2); tktb (Danio rerio, 161.4); tktl2 (Xenopus tropicalis, 184.1); CG8036 (Drosophila melanogaster, 176.0); tkt-1 (Caenorhabditis elegans, 163.3); AT3G60750 (Arabidopsis thaliana, 657.5)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005310.1:664467-666509:- | gene-YPR074C_AKU4011 | rna-NM_001184171.1_AKU4011 | cds-NP_015399.1_AKU4011 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000091.1:231175-233217:+ | gene-YPR074C_BG1 | rna-NM_001184171.1_BG1 | cds-NP_015399.1_BG1 | 99.3 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005518.1:742143-744185:- | gene-YPR074C_Bruggeman | rna-NM_001184171.1_Bruggeman | cds-NP_015399.1_Bruggeman | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005534.1:786459-788501:- | gene-YPR074C_CAT1 | rna-NM_001184171.1_CAT1 | cds-NP_015399.1_CAT1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005374.1:668158-670200:- | gene-YPR074C_CBS1585 | rna-NM_001184171.1_CBS1585 | cds-NP_015399.1_CBS1585 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005358.1:682532-684574:- | gene-YPR074C_CBS436 | rna-NM_001184171.1_CBS436 | cds-NP_015399.1_CBS436 | 99.9 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005342.1:671905-673947:- | gene-YPR074C_CBS6412 | rna-NM_001184171.1_CBS6412 | cds-NP_015399.1_CBS6412 | 99.5 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005326.1:665102-667144:- | gene-YPR074C_CBS6413 | rna-NM_001184171.1_CBS6413 | cds-NP_015399.1_CBS6413 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001537.1:692759-694801:- | gene-YPR074C_CENPK1137D | rna-NM_001184171.1_CENPK1137D | cds-NP_015399.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005486.1:991663-993705:- | gene-YPR074C_EthanolRed | rna-NM_001184171.1_EthanolRed | cds-NP_015399.1_EthanolRed | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005550.1:670300-672342:- | gene-YPR074C_FaliES1 | rna-NM_001184171.1_FaliES1 | cds-NP_015399.1_FaliES1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000443.1:3352-5394:- | gene-YPR074C_JAY291 | rna-NM_001184171.1_JAY291 | cds-NP_015399.1_JAY291 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005422.1:683403-685445:- | gene-YPR074C_MUCL30387 | rna-NM_001184171.1_MUCL30387 | cds-NP_015399.1_MUCL30387 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005454.1:682108-684150:- | gene-YPR074C_MUCL30388 | rna-NM_001184171.1_MUCL30388 | cds-NP_015399.1_MUCL30388 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005294.1:661415-663457:- | gene-YPR074C_MUCL39482 | rna-NM_001184171.1_MUCL39482 | cds-NP_015399.1_MUCL39482 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005438.1:724244-726286:- | gene-YPR074C_MUCL42920 | rna-NM_001184171.1_MUCL42920 | cds-NP_015399.1_MUCL42920 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011825.1:692779-694821:- | gene-YPR074C_NCIM3186 | rna-NM_001184171.1_NCIM3186 | cds-NP_015399.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005278.1:669592-671634:- | gene-YPR074C_NCYC1407 | rna-NM_001184171.1_NCYC1407 | cds-NP_015399.1_NCYC1407 | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994155.1:676222-678264:- | gene-YPR074C_PE2H3 | rna-NM_001184171.1_PE2H3 | cds-NP_015399.1_PE2H3 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999887.1:675870-677912:- | gene-YPR074C_PE2H4 | rna-NM_001184171.1_PE2H4 | cds-NP_015399.1_PE2H4 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001148.4:692796-694838:- | gene-YPR074C_S288C | rna-NM_001184171.1_S288C | cds-NP_015399.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000026.1:5848-7890:+ | gene-YPR074C_SA1 | rna-NM_001184171.1_SA1 | cds-NP_015399.1_SA1 | 99.9 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005502.1:670075-672117:- | gene-YPR074C_ThermosaccDry | rna-NM_001184171.1_ThermosaccDry | cds-NP_015399.1_ThermosaccDry | 99.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005470.1:686229-688271:- | gene-YPR074C_VR1 | rna-NM_001184171.1_VR1 | cds-NP_015399.1_VR1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000033.1:669303-671345:- | gene-YPR074C_ZTW1 | rna-NM_001184171.1_ZTW1 | cds-NP_015399.1_ZTW1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047502.1:670033-672075:- | gene-YPR074C_Sparadoxus | rna-NM_001184171.1_Sparadoxus | cds-NP_015399.1_Sparadoxus | 93.7 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |