Gene name: TIS11
Reference locus (S288C): YLR136C
Gene biotype: protein_coding
Description: mRNA decay factor CTH2; mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; TIS11 has a paralog, CTH1, that arose from the whole genome duplication
Top 10 interactors (score): DHH1 (0.981); FIT2 (0.976); CDC39 (0.938); AFT1 (0.924); SIT1 (0.921); ACO1 (0.91); MCX1 (0.91); NFU1 (0.908); ARN1 (0.875); POP2 (0.873); AFT2 (0.867); FET3 (0.823); WTM1 (0.813); SDH4 (0.813); CCC1 (0.813); FIT3 (0.802); ENB1 (0.784); FTR1 (0.784); NAB3 (0.765); YAP5 (0.76)
Homologues (species, bitscore): ZFP36 (Homo sapiens, 79.7); Zfp36l3 (Mus musculus, 80.1); zfp36l2 (Danio rerio, 85.1); zfp36l1 (Xenopus tropicalis, 82.0); Tis11 (Drosophila melanogaster, 76.6); mex-1 (Caenorhabditis elegans, 72.8); AT1G68200 (Arabidopsis thaliana, 64.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005306.1:398297-399154:- | gene-YLR136C_AKU4011 | rna-NM_001182023.1_AKU4011 | cds-NP_013237.1_AKU4011 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000212.1:362065-362922:- | gene-YLR136C_BG1 | rna-NM_001182023.1_BG1 | cds-NP_013237.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005514.1:410166-411023:- | gene-YLR136C_Bruggeman | rna-NM_001182023.1_Bruggeman | cds-NP_013237.1_Bruggeman | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005530.1:409575-410432:- | gene-YLR136C_CAT1 | rna-NM_001182023.1_CAT1 | cds-NP_013237.1_CAT1 | 99.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005370.1:405441-406298:- | gene-YLR136C_CBS1585 | rna-NM_001182023.1_CBS1585 | cds-NP_013237.1_CBS1585 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005354.1:395665-396522:- | gene-YLR136C_CBS436 | rna-NM_001182023.1_CBS436 | cds-NP_013237.1_CBS436 | 99.8 | 100.0 | Mismatch | 1 | 1 | 1 | False | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005338.1:403858-404715:- | gene-YLR136C_CBS6412 | rna-NM_001182023.1_CBS6412 | cds-NP_013237.1_CBS6412 | 99.7 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005322.1:405706-406563:- | gene-YLR136C_CBS6413 | rna-NM_001182023.1_CBS6413 | cds-NP_013237.1_CBS6413 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001533.1:400821-401678:- | gene-YLR136C_CENPK1137D | rna-NM_001182023.1_CENPK1137D | cds-NP_013237.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005482.1:398498-399355:- | gene-YLR136C_EthanolRed | rna-NM_001182023.1_EthanolRed | cds-NP_013237.1_EthanolRed | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005546.1:398009-398866:- | gene-YLR136C_FaliES1 | rna-NM_001182023.1_FaliES1 | cds-NP_013237.1_FaliES1 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000061.1:4669-5526:- | gene-YLR136C_JAY291 | rna-NM_001182023.1_JAY291 | cds-NP_013237.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005418.1:410171-411028:- | gene-YLR136C_MUCL30387 | rna-NM_001182023.1_MUCL30387 | cds-NP_013237.1_MUCL30387 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005450.1:414974-415831:- | gene-YLR136C_MUCL30388 | rna-NM_001182023.1_MUCL30388 | cds-NP_013237.1_MUCL30388 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005290.1:405950-406807:- | gene-YLR136C_MUCL39482 | rna-NM_001182023.1_MUCL39482 | cds-NP_013237.1_MUCL39482 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005434.1:406078-406935:- | gene-YLR136C_MUCL42920 | rna-NM_001182023.1_MUCL42920 | cds-NP_013237.1_MUCL42920 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011821.1:415775-416632:- | gene-YLR136C_NCIM3186 | rna-NM_001182023.1_NCIM3186 | cds-NP_013237.1_NCIM3186 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005274.1:398222-399079:- | gene-YLR136C_NCYC1407 | rna-NM_001182023.1_NCYC1407 | cds-NP_013237.1_NCYC1407 | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994151.1:403775-404632:- | gene-YLR136C_PE2H3 | rna-NM_001182023.1_PE2H3 | cds-NP_013237.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999883.1:403516-404373:- | gene-YLR136C_PE2H4 | rna-NM_001182023.1_PE2H4 | cds-NP_013237.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001144.5:415801-416658:- | gene-YLR136C_S288C | rna-NM_001182023.1_S288C | cds-NP_013237.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000055.1:41711-42568:- | gene-YLR136C_SA1 | rna-NM_001182023.1_SA1 | cds-NP_013237.1_SA1 | 99.5 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005498.1:399219-400076:- | gene-YLR136C_ThermosaccDry | rna-NM_001182023.1_ThermosaccDry | cds-NP_013237.1_ThermosaccDry | 99.7 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005466.1:411916-412773:- | gene-YLR136C_VR1 | rna-NM_001182023.1_VR1 | cds-NP_013237.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000023.1:397013-397870:- | gene-YLR136C_ZTW1 | rna-NM_001182023.1_ZTW1 | cds-NP_013237.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047498.1:407029-407886:- | gene-YLR136C_Sparadoxus | rna-NM_001182023.1_Sparadoxus | cds-NP_013237.1_Sparadoxus | 89.4 | 99.8 | Verified | 1 | 1 | 1 | False | True | False | False | False |