Gene name: TIM8
Reference locus (S288C): YJR135W-A
Gene biotype: protein_coding
Description: Mitochondrial import inner membrane translocase subunit TIM8; Mitochondrial intermembrane space protein; forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome, also known as deafness-dystonia-optic neuronopathy (DDON) syndrome; human TIMM8A can complement yeast null mutant
Top 10 interactors (score): TIM9 (0.999); TIM13 (0.999); TIM10 (0.999); TIM23 (0.998); MIA40 (0.998); TIM12 (0.998); TOM22 (0.996); TOM40 (0.996); TOM7 (0.992); ERV1 (0.99); TIM17 (0.989); COX17 (0.989); PAM16 (0.979); TIM50 (0.977); COX19 (0.973); MDM35 (0.965); TIM54 (0.962); MIX17 (0.951); SAM50 (0.951); MIX14 (0.95)
Homologues (species, bitscore): TIMM8A (Homo sapiens, 62.4); Timm8a2 (Mus musculus, 63.9); timm8a (Danio rerio, 58.9); Tim8 (Drosophila melanogaster, 54.7)
External links:
Saccharomyces genome database (SGD)
STRING database
BioGRID
UniProt Knowledgebase
Kyoto encyclopedia of genes and genomes (KEGG)
Reactome
UCSC Genome Browser
| strain | assembly | application | macro_region | gene_coord | geneID | rnaID | protID | %id | %cov_exon | status | copyNumber | copyID | nORFs | match_ref_CDS | validORF | missing_startCodon | missing_stopCodon | outOfFrame_stopCodon |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AKU4011 | GCA_001738255.1 | Sake | Asia | CM005304.1:648469-648732:+ | gene-YJR135W-A_AKU4011 | rna-NM_001184382.1_AKU4011 | cds-NP_058168.1_AKU4011 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| BG1 | GCA_001932575.1 | Bioethanol | South America | MSHP01000076.1:24868-25131:- | gene-YJR135W-A_BG1 | rna-NM_001184382.1_BG1 | cds-NP_058168.1_BG1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Bruggeman | GCA_001738585.1 | Bread | Not Applicable | CM005512.1:664199-664462:+ | gene-YJR135W-A_Bruggeman | rna-NM_001184382.1_Bruggeman | cds-NP_058168.1_Bruggeman | 99.2 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CAT1 | GCA_001738705.1 | Bioethanol | South America | CM005528.1:668838-669101:+ | gene-YJR135W-A_CAT1 | rna-NM_001184382.1_CAT1 | cds-NP_058168.1_CAT1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS1585 | GCA_001738375.1 | Sake | Asia | CM005368.1:660513-660776:+ | gene-YJR135W-A_CBS1585 | rna-NM_001184382.1_CBS1585 | cds-NP_058168.1_CBS1585 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CBS436 | GCA_001738355.1 | Sake | Asia | CM005352.1:679385-679648:+ | gene-YJR135W-A_CBS436 | rna-NM_001184382.1_CBS436 | cds-NP_058168.1_CBS436 | 100.0 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6412 | GCA_001738345.1 | Sake | Asia | CM005336.1:647290-647553:+ | gene-YJR135W-A_CBS6412 | rna-NM_001184382.1_CBS6412 | cds-NP_058168.1_CBS6412 | 99.2 | 100.0 | Mismatch | 1 | 1 | 1 | True | True | False | False | False |
| CBS6413 | GCA_001738265.1 | Sake | Asia | CM005320.1:649947-650210:+ | gene-YJR135W-A_CBS6413 | rna-NM_001184382.1_CBS6413 | cds-NP_058168.1_CBS6413 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| CENPK1137D | GCA_000269885.1 | Laboratory | Not Applicable | CM001531.1:659331-659594:+ | gene-YJR135W-A_CENPK1137D | rna-NM_001184382.1_CENPK1137D | cds-NP_058168.1_CENPK1137D | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| EthanolRed | GCA_001738615.1 | Bioethanol | Asia | CM005480.1:652890-653153:+ | gene-YJR135W-A_EthanolRed | rna-NM_001184382.1_EthanolRed | cds-NP_058168.1_EthanolRed | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| FaliES1 | GCA_001738715.1 | Bioethanol | Asia | CM005544.1:664353-664616:+ | gene-YJR135W-A_FaliES1 | rna-NM_001184382.1_FaliES1 | cds-NP_058168.1_FaliES1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| JAY291 | GCA_000182315.2 | Bioethanol | South America | ACFL01000054.1:24541-24804:- | gene-YJR135W-A_JAY291 | rna-NM_001184382.1_JAY291 | cds-NP_058168.1_JAY291 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30387 | GCA_001738515.1 | Bread | Europe | CM005416.1:663230-663493:+ | gene-YJR135W-A_MUCL30387 | rna-NM_001184382.1_MUCL30387 | cds-NP_058168.1_MUCL30387 | 99.2 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL30388 | GCA_001738495.1 | Bread | Europe | CM005448.1:660714-660977:+ | gene-YJR135W-A_MUCL30388 | rna-NM_001184382.1_MUCL30388 | cds-NP_058168.1_MUCL30388 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| MUCL39482 | GCA_001738235.1 | Sake | Asia | CM005288.1:653998-654261:+ | gene-YJR135W-A_MUCL39482 | rna-NM_001184382.1_MUCL39482 | cds-NP_058168.1_MUCL39482 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| MUCL42920 | GCA_001738485.1 | Bread | Europe | CM005432.1:658735-658998:+ | gene-YJR135W-A_MUCL42920 | rna-NM_001184382.1_MUCL42920 | cds-NP_058168.1_MUCL42920 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| NCIM3186 | GCA_001029075.1 | Bioethanol | Asia | CP011819.1:676950-677213:+ | gene-YJR135W-A_NCIM3186 | rna-NM_001184382.1_NCIM3186 | cds-NP_058168.1_NCIM3186 | 98.4 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |
| NCYC1407 | GCA_001738225.1 | Sake | Asia | CM005272.1:651547-651810:+ | gene-YJR135W-A_NCYC1407 | rna-NM_001184382.1_NCYC1407 | cds-NP_058168.1_NCYC1407 | 98.8 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H3 | GCA_905220325.1 | Bioethanol | South America | HG994149.1:669737-670000:+ | gene-YJR135W-A_PE2H3 | rna-NM_001184382.1_PE2H3 | cds-NP_058168.1_PE2H3 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| PE2H4 | GCA_905220315.1 | Bioethanol | South America | LR999881.1:663426-663689:+ | gene-YJR135W-A_PE2H4 | rna-NM_001184382.1_PE2H4 | cds-NP_058168.1_PE2H4 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| S288C | GCF_000146045.2 | Laboratory | Not applicable | NC_001142.9:676971-677234:+ | gene-YJR135W-A_S288C | rna-NM_001184382.1_S288C | cds-NP_058168.1_S288C | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| SA1 | GCA_004114265.1 | Bioethanol | South America | SDIA01000069.1:24893-25156:- | gene-YJR135W-A_SA1 | rna-NM_001184382.1_SA1 | cds-NP_058168.1_SA1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ThermosaccDry | GCA_001738605.1 | Bioethanol | Asia | CM005496.1:658284-658547:+ | gene-YJR135W-A_ThermosaccDry | rna-NM_001184382.1_ThermosaccDry | cds-NP_058168.1_ThermosaccDry | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| VR1 | GCA_001738595.1 | Bioethanol | South America | CM005464.1:660657-660920:+ | gene-YJR135W-A_VR1 | rna-NM_001184382.1_VR1 | cds-NP_058168.1_VR1 | 100.0 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| ZTW1 | GCA_000308935.1 | Bioethanol | Asia | AMDD01000021.1:637633-637896:+ | gene-YJR135W-A_ZTW1 | rna-NM_001184382.1_ZTW1 | cds-NP_058168.1_ZTW1 | 99.6 | 100.0 | Verified | 1 | 1 | 1 | True | True | False | False | False |
| Sparadoxus | GCF_002079055.1 | Not applicable | Not applicable | NC_047496.1:671925-672188:+ | gene-YJR135W-A_Sparadoxus | rna-NM_001184382.1_Sparadoxus | cds-NP_058168.1_Sparadoxus | 92.8 | 100.0 | Verified | 1 | 1 | 1 | False | True | False | False | False |